Phone: (706) 721-7742
Fax: 706) 721-7299

Email: cwebb@mcg.edu
Office: CA-3123

The physiology of vascular smooth muscle, with particular emphasis placed on:

1. 1) vascular reactivity in hypertension and diabetes
2. 2) penile erection
3. 3) cellular and subcellular mechanisms of contraction and relaxation of vascular smooth muscle (cell signaling, electrogenic sodium pump, subcellular calcium distribution, monovalent cation movements, nitric oxide, RhoA/Rho kinase, etc.),
4. 4) adrenergic neurotransmission in blood vessels
5. 5) intercellular communication between vascular smooth muscle cells.

Go to PubMed

Goncalves AC, Silva RA, Couto AS, Nicolau M, Webb RC and Leite R. Quercetin fully restores penile function in DOCA hypertensive rats. FASEB J. 19:A1623, 2005.

Leite R, Jin L and Webb RCb. Chronic angiotensin II-induced hypertension causes erectile dysfunction in rats. FASEB J 19:A1623, 2005.

Ying Z, Jin L, Palmer T and Webb RC. PDZ-RhoGEF mediates the Ca2+ sensitization induced by angiotensin II in vascular smooth muscle cells. FASEB J 19:A1613, 2005.

Hilgers RHP, Jin L, Palmer TD and Webb RC. Characterization of signaling pathways involved in the spontaneous tone in hypertensive rats. FASEB J 19:A1559, 2005.

Linder AE, McCluskey LP and Webb RC. Dynamic association of guanylyl cyclase and protein kinase G with caveolin-1 in rat aortic endothelium. FASEB J 19:A1274, 2005.

Jin L, Teixeira C and Webb RC. Comparison of the effect of protein kinase C (PKC) on agonist-induced contraction in mouse corpus cavernosum and aorta. FASEB J 19:A537, 2005.

Leite R, Linder AE, Jin L, Mills TM and Webb RC. Angiotensin dependent and 2K1C hypertension do not cause significant impaired erectile response in rats. Hypertension 44:564, 2004.

Ying Z, Jin L, Palmer T and Webb RC. RhoA/Rho-kinase dependent Ca2+ sensitization is modulated by age: RGS domain containing RhoGEF are the culprits. Hypertension 44:563, 2004.

Linder AE and Webb RC. Endothelium-dependent responses mediated by cyclic GMP in rat aorta. Hypertension 44:562, 2004.

Yin J, Jin L, Ying Z and Webb RC. Activation of NADPH oxidase contributes to RhoA/Rho-kinase dependent contraction induced by angiotensin II. Hypertension 44:560, 2004.