Hypertension is a major health problem in the United States. Although the exact mechanisms that cause hypertension are not fully understood, it has been linked to the kidneys. The kidneys play a key role in regulating blood pressure, and substances which affect salt excretion and the function of renal blood vessels are important factors to cause hypertension. My major research interests are to study the role of cytochrome P450 (CYP)-derived eicosanoids (20-HETE and EETs) in the regulation of renal function and blood pressure. 20-HETE and EETs, arachidonic acid derived metabolites, can cause the constriction or dilation of blood vessels, affect renal electrolyte reabsorption in the nephron, and have been shown to be associated with hypertension. My present projects set the basis to understanding the regulation mechanisms for the synthesis of these eicosanoids in the kidneys of different animal models related to pregnancy and obesity. Ultimately, the knowledge can uncover new therapeutic targets and provide new information for the control and treatment of hypertension.
Role of renal tubular 20-HETE and EETs on sodium retention in obese rats.
Renal EET biosynthesis in pregnancy.
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H. Huang, H.H. Chang, Y. Xu, D.S. Reddy, J. Du, Y. Zhou, Z. Dong, J.R. Falck,
M.H. Wang, "Epoxyeicosatrienoic acid inhibition alters renal hemodynamics during pregnancy", Exp. Bio. Med., 2006, in press.
Y. Zhou, H. Huang, H.H. Chang, J. Du, J.F. Wu, C.Y. Wang,
M.H. Wang, "Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat-diet induced hypertension in rats", J. Pharmacol. Exp. Ther., 317, 11-18, 2006.
H. Huang, Y. Zhou, V.T. Raju, Y. Du, H.H. Chang, C.Y. Wang, M.W. Brands, J.R. Falck,
M.H. Wang, "Renal 20-HETE inhibition attenuates the changes of renal hemodynamics induced by L-NAME treatment in pregnant rats", Am. J. Physiol., 289, F1116-F1122, 2005.
Y. Zhou, S. Lin, H.H. Chang, J. Du, Z. Dong, A.M. Dorrance, M.W. Brands,
M.-H. Wang, "Gender difference of renal CYP-derived eicosanoid synthesis in rats fed a high-fat diet", Am. J. Hypertens., 18: 530-537, 2005.
Y. Zhou, H.H. Chang, J. Du, C.Y. Wang, Z. Dong,
M.-H. Wang, "Renal epoxyeicosatrienoic acid synthesis during pregnancy", Am. J. Physiol., 288, F221-F226, 2005.
M.-H. Wang, A. Smith, Y. Zhou, H.H. Chang, S. Lin, X. Zhao, J.D. Imig, A.M. Dorrance, "Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet induced hypertension", Hypertension, 42, 594-599, 2003.
M.-H. Wang, J. Wang, H.H. Chang, B.A. Zand, M. Jiang, A. Nasjletti, M.L. Schwartzman, " Regulation of renal CYP4A expression and 20-hydroxyeicosatetraenoic acid synthesis by nitric oxide in pregnant rats", Am. J. Physiol., 285, F295-F302, 2003.
M.-H. Wang, B. Zand, A. Nasjletti, M.L. Schwartzman, "20-Hydroxyeicosatetraenoic acid synthesis in the rat during pregnancy". Am. J. Physiol., 282, R383-389, 2002.
M.-H. Wang, F. Zhang, J. Marji, B. Zand, A. Nasjletti, M.L. Schwartzman, "CYP4A1 antisense oligonucleotide reduces mesenteric reactivity and blood pressure in SHR", Am. J. Physiol.,280, R255-261, 2001.
M.-H. Wang, E. Brand-Schieber, B.A. Zand, X. Nguyen, J.R. Falck, N. Balu, M.L. Schwartzman, "Cytochrome P450-derived arachidonic acid metabolism in the rat kidney : characterization of selective inhibitors", J. Pharmacol. Exp. Ther., 284, 966-973, 1998.
