Phone: (706) 721-7851
Fax: (706) 721-7299

Email: pkruzich@mail.mcg.edu
Office: CA-2098

My laboratory investigates the neural, genetic, and environmental mechanisms that influence the susceptibility to acquire uncontrollable psychostimulant administration and subsequently psychostimulant addiction. We use a variety of pharmacological, neurochemical, molecular, and behavioral techniques with rats and genetically engineered mice.

My laboratory is currently investigating the role of ionotropic glutamate receptors in preclinical models of cocaine relapse utilizing rats and mice. A second area of research is investigating the contribution of cytokines and stress in the susceptibility to acquire cocaine self-administration in rats and mice.

Jinlei Xi - MD, MS.

Ansong Ping - MD, PhD

Go to PubMed

Kruzich PJ, Xi J (2006) Differences in extinction responding and reinstatement of methamphetamine-seeking behavior between Fischer 344 and Lewis Rats. Pharmacology, Biochemistry and Behavior 83(3):391-5.

Kruzich PJ, Xi J (2006). Different patterns of pharmacological reinstatement of cocaine-seeking behavior between Fischer 344 and Lewis Rats. Psychopharmacology 187(1):22-9.

Kruzich PJ, Mitchell SH, Younkin A, Grandy DK (2006). Dopamine D-sub-2 receptors mediate reversal learning in male C57BL/6J mice. Cognitive, Affective & Behavioral Neuroscience 6(1) 86-90.

Kruzich PJ, Suchland KM, Grandy DK (2004) Dopamine D4 receptor deficient mice, congenic on the C57BL/6J background, are hypersensitive to amphetamine. Synapse, 53 (3):131-139.

Kruzich PJ, Grandy DK (2004) Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice. BMC Neuroscience, 5:12.

Kruzich PJ, Chen AC, Unterwald EM, Kreek MJ (2003) Subject-regulated dosing alters morphine self-administration behavior and morphine-stimulated [35S]GTP?S binding. Synapse, 47(4):243-9.

Kruzich PJ, Congleton KM, See RE (2001) Conditioned Reinstatement of Drug-seeking Behavior with a Discrete Compound Stimulus Classically Conditioned with Intravenous Cocaine. Behavioral Neuroscience, 115(5):1086-92.

Kruzich PJ, See RE (2001) Differential contributions of the basolateral and central amygdala in the acquisition and expression of conditioned relapse to cocaine-seeking behavior. Journal of Neuroscience, 21:RC155(1-5).

Kruzich PJ, See RE (2000) An evaluation of the role of 5-HT2 receptor antagonism during subchronic antipsychotic drug administration in rats. Brain Research, 875(1-2): 35-43.

Kruzich PJ, Grimm JW, Rustay NR, Parks CD, See RE (1999) Predicting relapse to cocaine-seeking behavior: A multiple regression approach. Behavioural Pharmacology, 10(5): 513-521.