The overall interests of the lab are the influence of estrogen and natural estrogenic compounds on the brain with particular reference to postmenopausal hormone replacement. We recently demonstrated a neuroprotective effect of a high soy diet containing phytoestrogens in female rats undergoing experimental stroke. We are now using in vivo and in vitro models to examine neuroprotection during stroke and stroke-like injury. Studies involve approaches from the molecular/cellular level all the way up to animal behavior after recovery from experimental stroke. Cell lines, primary neurons, and endothelial cells are used to examine mechanisms of estrogen and phytoestrogen actions at the cellular/molecular level through gene expression profiling and manipulation or pharmacological activation or blockade of signaling pathways. A rat model of stroke is used for gene expression profiling, pharmacological manipulations, and behavioral studies.
Woube Bekele, B.S. - Research Assistant
Christian Deutsch, B.S. - Research Associate
Yu-Lin Ma, M.D. - Research Associate
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Tara Lovekamp-Swan, Michele L. Glendenning, Derek A. Schreihofer. A high soy diet reduces programmed cell death and enhances bcl-XL expression in experimental stroke 2007 Neuroscience 148: 644-652.
Tara Lovekamp-Swan, Michele L. Glendenning, Derek A. Schreihofer. A high soy diet enhances neurotropin receptor and Bcl-XL gene expression in the brains of ovariectomized female rats 2007 Brain Res 1159: 54-66.
Derek A. Schreihofer, Khoi D. Do, Ann M. Schreihofer. High soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats. American Journal of Physiology, Regul Integr Comp Physiol. 2005 Jul;289(1):R103-8.
Derek A. Schreihofer. Transcriptional regulation by phytoestrogens in neuronal cell lines. Molecular and Cellular Endocrinology. 2005:231; 13-22.
Derek A. Schreihofer, Daniel F. Rowe, Emilie F. Rissman, Elke Scordalakes, Jan- Åke Gustafsson, Margaret A. Shupnik. Estrogen receptor-α (ERα) but not estrogen receptor-β modulates estrogen stimulation of the ERα truncated variant TERP-1 and is not required for basal expression Endocrinology. 2002:143; 4196-202.
Derek A. Schreihofer, Eileen M. Resnick, Vicky Y. Lin, Margaret A. Shupnik. Ligand-independent activation of pituitary estrogen receptors: Dependence on protein kinase A-stimulated pathways. Endocrinology, 2001: 142; 3361-3368.
Derek A. Schreihofer, Mark H. Stoler, Margaret A. Shupnik. Differential expression and regulation of estrogen receptors [ERs] in rat pituitary and cell lines: Estrogen decreases ERa protein and estrogen responsiveness. Endocrinology, 2000: 141; 2174-2184.
Eileen M. Resnick, Derek A. Schreihofer, Ammasi Peryasami, Margaret A. Shupnik. Truncated estrogen receptor product-1 (TERP-1) acts through dimerization with full-length estrogen receptors α and β. Journal of Biological Chemistry, 2000: 275; 7158-7166.
Derek A. Schreihofer, Eileen M. Resnick, Ann Y. Soh, Margaret A. Shupnik. Transcriptional regulation by a naturally occurring truncated rat estrogen receptor (ER), Truncated ER product-1 (TERP-1). Molecular Endocrinology, 1999: 13; 320-329.
