Cardiovascular-renal integrative physiology and hypertension. Longstanding interest in renal and hormonal mechanisms for chronic blood pressure and circulatory system control in states of insulin resistance, hyperinsulinemia, and diabetes. New research area focuses on mechanisms through which IL-6 and other inflammatory cytokines influence acute and long-term blood pressure control.
Mechanisms through which angiotensin II and nitric oxide control glomerular filtration rate and renal blood flow, and thereby control blood pressure in metabolic syndrome and at the earliest stages of diabetes.
Mechanisms through which interleukin-6 mediates the chronic hypertensive effect of angiotensin II and the acute hypertensive response to psychosocial stress.
Marlina Manhiani, Ph.D. Research Associate
LaShon Sturgis, Ph.D. Research Associate
Ashlyn Allen Research Assistant
Tuere Sheppard Research Technician
Go to PubMed
Lee, D.L., L.C. Sturgis, H.Labazi, J.B. Osborne, Jr., C. Fleming, J.S. Pollock, M. Manhiani, J.D. Imig, and M.W. Brands. Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. Am. J. Physiol Heart Circ Physiol, Am J Physiol Heart Circ Physiol. 290:H935-H940, 2006.
Rojas, M., T.D. Bell, L.C. Sturgis, R. Janardhanan, V. Springfield, C. Fleming, and M.W. Brands. Blood pressure early in diabetes depends on a balance between glomerular filtration rate and the renin-angiotensin system. Am. J. Hypertension 19:1249-1255, 2006.
Bell, T.D., G.F. DiBona, Y.Wang, and M.W. Brands. Mechanisms for renal blood flow control early in diabetes as revealed by chronic flow measurement and transfer function analysis. J. Am. Soc. Nephrol. 17:2184-2192, 2006.
Brands, M.W., C. Fleming, T.D. Bell, L.C. Sturgis, R. Janardhanan, and H. Labazi. Lack of blood pressure salt-sensitivity supports afferent arteriolar action of nitric oxide in Type I diabetes. Clin. Expr. Pharm. Physiol., 34:475-479, 2007.
Carter, B.L., P.T. Einhorn, M.W. Brands, J.A. Cutler, P.K. Whelton, G.L. Bakris, F.L. Brancati, W.C. Cushman, S. Oparil, and J.T. Wright, Jr.; Working Group from the NHLBI. Thiazide-induced dysglycemia: call for research from a working group from the national heart, lung, and blood institute. Hypertension. 52:30-36, 2008.
Brands, M.W. and H. Labazi. The Role of Glomerular Filtration Rate in Controlling Blood Pressure Early in Diabetes. Hypertension 52:188-194, 2008.
Bell, T.D., G.F. DiBona, Y.Wang, and M.W. Brands. Continuously-Measured Renal Blood Flow Does Not Increase in Diabetes if Nitric Oxide Synthesis is Blocked. Am. J. Physiol. Renal Physiol. 295:F1449-F1456, 2008.
Brands, M.W., T.D. Bell, N.A. Rodriguez, P. Polavarapu, and D. Panteleyev. Chronic glucose infusion causes sustained increases in tubular sodium reabsorption and renal blood flow in dogs. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296:R265-R271, 2009.
Sturgis, L.C., J.G. Cannon, D.A. Schreihofer, and M.W. Brands. Stimulation of IL-6 by mineralocortocoids contributes to angiotensin II, but not mineralocorticoid, hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol, In review.
Banes-Berceli, A.K.L., M.W. Brands, C. Hill-Pryor, and H. Labazi. Inhibition of Janus Kinase 2 prevents Angiotensin II-induced hypertension. J. Am. Soc. Nephrol. In review.
