Phone: (706) 721-7649
Fax: (706) 721-2347

Email: rrudic@mail.mcg.edu

Office: CB-3620

Grant Support as Principal Investigator | Current Projects | Lab | Honors & Awards | Invited Speaker | Selected Publications |

The cardiovascular system exhibits daily oscillations. These patterned rhythms which occur in blood pressure, heart rate, and vascular tone, occur to a 24-hour beat -- a circadian rhythm. The transcription factors Bmal1 and Clock comprise the molecular basis of rhythmic patterns in sleeping and waking mediated via central actions in the brain. Though also expressed peripherally in blood vessels and heart, the influence of Bmal1 and Clock on cardiovascular rhythms is unknown. Thus, our main research interest in the laboratory is to examine the contribution of Bmal1 and Clock, two essential components of circadian rhythms, in cardiovascular function. Our research may provide novel insights into the morning occurrence of heart attack, stroke, and the evolution of diabetes.

7K01DK070658-02 Rudic (PI) - Medical College of Georgia
12/12/05-4/01/2010
NIDDK
"Peripheral clocks in metabolism and diabetes" The major goal of this project is to examine the influence of the molecular clock on the evolution of diabetes.

• Circadian clock regulation in the vascular system.
• Role of Bmal1 and Clock in vascular remodeling and diabetes.
• Novel pathways in vascular remodeling.

Bryan Simkins - Research Assistant
Keith Beckman - Rotation Student

Lab Website

• 2004 - ATVB Irvine Page Young Investigator Award Finalist
• 2003 - ATVB New Investigator Travel Award
• 2002 - American Heart Association Post-Doctoral Fellowship
• 2000 - NRSA Post-Doctoral Fellowship
• 1987-1991 - Outstanding Achievement Scholarship, Temple University

July, 2005 - Harvard University, Department of Pathology, Boston, MA.

Rudic RD, Curtis AM, Cheng Y, FitzGerald GA. Peripheral clocks and regulation of cardiovascular and metabolic function. Methods in Enzymology 2005; 393: 524-539.

Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S, Hogenesch JB, FitzGerald GA. Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation 2005; 112: 2716-2724.

Rudic RD, Brinster D, Cheng Y., Song W-L, Fries S, Coffman T, FitzGerald GA. COX-2 derived prostacyclin modulates vascular remodeling. Circ Res 2005; 96(12):1240-7.

Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA. BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis. PLoS Biol 2004;2(11):e377.

McNamara P, Seo SP, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell 2001;105(7):877-89.**

Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G, Sessa WC. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med 2000;6(12):1362-7.

Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 1998;101(4):731-6.



**Cell Cover Reprinted from CELL, Vol number 105, number 7, McNamara P, Seo SP, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA., Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock., 877-89., Copyright (June 29, 2001), with permission from Elsevier