My research interests involve signaling mechanisms in pulmonary hypertension. Specifically, my research projects involve regulation of the calcium- and voltage-activated potassium channel (BKCa) in pulmonary arterial smooth muscle. Presently, I am investigating the role of protein kinase C (PKC) on cAMP-induced pulmonary vasodilation through regulation of the BKCa channel. A second research area involves estrogen signaling in pulmonary arterial smooth muscle. Evidence shows that estrogen can either open or close this ion channel depending on the phenotypic state (hypertensive or normotensive) of the pulmonary blood vessels. Therefore the specific question being asked is through what mechanisms does estrogen influence the BKCa channel to alter pulmonary blood pressure. My investigation of the above research projects utilizes current techniques of electrophysiology, vascular contraction, and biochemistry/molecular biology to determine how PKC and estrogen regulate BKCa channel function in pulmonary arterial smooth muscle. The long-term goal of my research is to understand the molecular basis of how PKC and estrogen regulate BKCa channel function in pulmonary hypertension.
NIH RO1 AWARD - "PKC Signaling in cAMP-Induced Pulmonary Vasodilation" (S.A. Barman, P.I., 2001-2005 with no-cost extension for 2006; $700,000; Competitive Renewal 2006-2011; $1,250,000-pending)
NIH RO1 AWARD - "Molecular Basis of Estrogen Dual Effects on Coronary Arteries " (S.A. Barman, Collaborator, 2004-2009; $1,121,440)
American Heart Association - Southeast Affiliate, Inc. Grant-in-Aid Award - "Novel Mechanisms of Estrogen Signaling in Pulmonary Arteries" (S.A. Barman, P.I., 2005-2007, $140,000)
Mary Louise Meadows - Research Assistant 3.
Shu Zhu - Graduate Student (Dr. Barman mentoring Ph.D.research project with Dr. White).
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Certificate for volunteer services for CARE-MEDICO - Kabul, Afghanistan, August 1976; August 1977.
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Dean's List, Muhlenberg College, 1976-1977; 1979-1980.
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Graduate Research Assistantship, 1981-1982; Department of Physiology, University of North Dakota.
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Graduate Research Assistantship, 1984-1985; Department of Physiology, University of North Dakota.
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Graduate Research Assistantship, 1985-1986; Department of Physiology, University of North Dakota.
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North Dakota State Board of Higher Education Scholarship, 1983.
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North Dakota State Board of Higher Education Scholarship, 1984.
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Sigma Xi 'Graduate Student Award for Outstanding Scientific Research' (University of North Dakota Chapter), 1986.
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Graduate Student Research Award, University of North Dakota School of Medicine, 1986.
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American Heart Association, Alabama Affiliate Training Fellowship, 1987-1988.
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NIH NRSA Award, 1988-1990.
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Outstanding Young Faculty Member Award (Basic Sciences) - Medical College of Georgia, 1993.
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Department of Pharmacology & Toxicology Teaching Award - 2000
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Outstanding Leadership and Service Award - General Faculty Assembly of the Medical College of Georgia, 2001.
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School of Graduate Studies Distinguished Service Award -2002
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Outstanding Service Award - Co-Parliamentarian of Academic Council - 2003
The effect of verapamil on histamine induced lanthanum binding in the isolated rabbit heart. Department of Physiology, University of South Alabama, 1985.
The effect of verapamil on lanthanum binding in rabbit myocardium. Department of Physiology, University of Kentucky, 1985.
The alterations in lanthanum binding by histamine to vascular endothelium. Department of Physiology, USUHSF. Edward Herbert School of Medicine, 1985.
Histamine receptors in the canine pulmonary circulation. Symposium, APS Fall Meeting, 1989.
The effect of histamine and acetylcholine on the resistance-compliance profile of the pulmonary circulation. Department of Physiology, Northeastern Ohio Universities College of Medicine, 1989.
The effect of histamine, acetylcholine, and elevated venous pressure on the segmental resistance-compliance profile of the pulmonary circulation. Department of Physiology, CUNY Medical School, 1990.
The effect of elevated vascular tone on the pulmonary circulation. Department of Oral Biology, University of Nebraska, 1990.
The effect of elevated vascular tone on the histaminergic and cholinergic mediated vascular responses in the pulmonary circulation. Department of Pharmacology and Toxicology, Medical College of Georgia, 1990.
The effect of histamine, acetylcholine, and endothelin-1 on the segmental distribution of vascular resistance and compliance in the pulmonary circulation. Department of Critical Care Medicine, Michael Reese Hospital, 1990.
The resistance-compliance profile of the pulmonary circulation. Department of Biomedical Engineering, University of Virginia, 1990.
The contributions of the pulmonary and systemic circulations to airway blood flow. International Symposium on Airway Circulation in Health and Disease. Foligno, Italy, 1991.
PKC Modulation of BKCa Channel Activity in Pulmonary Arterial Smooth Muscle. Department of Pharmacology & Physiology & Therapeutics, University of North Dakota School of Medicine, 2004
Barman, S.A. Pulmonary vasoreactivity to endothelin-1 at elevated vascular tone is mediated by potassium channels. J. Appl. Physiol. 80: 91-98, 1996.
Hager, J.C., A.A. Barman, A.L. Statsinger, S.A. Barman, and C. Chen. Endothelial cell injury in the human saphenous vein. A comparative study of two circular valvulotomes. Cardiovasc. Surg. 3: 291-292, 1995.
Orfanos, S.E., I.C. Ehrhart, S.A. Barman, W.F. Hofman, and J.D. Catravas. Endothelial ectoenzyme assays estimate perfused surface area in the dog lung. Microvas. Res. 54: 145-155, 1997.
Barman, S.A. Role of calcium-activated potassium channels and cyclic nucleotides on Pulmonary vasoreactivity to serotonin. Am. J. Physiol. L142-L147, 1997.
Barman, S.A., J.R. Pauly, and C.M. Isales. Canine Pulmonary Vasoreactivity to Serotonin: Role of Protein kinase C and Tyrosine kinase. Am. J. Physiol. 272: H740-H747, 1997.
Barman, S.A., L.L. McCloud, J.D. Catravas, and I.C. Ehrhart. Measurement of pulmonary blood flow by fractal analysis of flow heterogeneity in isolated canine lungs. J. Appl. Physiol. 81: 2039-2045, 1996.
Barman, S.A., S.S. Chaudhry, A.S. Moideen, J. Iljas, and A.A. Barman. Measurement of thromboxane and prostacyclin in valvulotomized human saphenous veins. Amer. Surg. 63: 291-293, 1997.
Barman, S.A. Pulmonary vasoreactivity to serotonin during hypoxia is modulated by ATP- sensitive potassium channels. J. Appl. Physiol 83: 569-574, 1997.
Barman, S.A. Potassium channels modulate hypoxic pulmonary vasoconstriction. Am. J. Physiol. 275: L64-L70, 1998.
Barman, S.A., and C.M. Isales. Fenfluramine potentiates canine pulmonary vasoreactivity to endothelin-1. Pul. Pharmacol. and Thera. 11: 183-187, 1998.
Barman, S.A. Potassium Channels Modulate Pulmonary Vasoreactivity to Protein Kinase C. Am. J. Physiol. 277: L558-L565, 1999.
Barman, S.A. Effect of Protein Kinase C Inhibition on Hypoxic Pulmonary Vasoconstriction. Am. J. Physiol. 280: L888-L895, 2001.
Barman, S.A., S. Zhu, G. Han, and R.E. White. cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am. J. Physiol. 284: L1004-L1011, 2003.
Johnson, J.A and S.A. Barman. Protein Kinase C Modulation of Cyclic GMP in Rat Neonatal Pulmonary Vascular Smooth Muscle. Lung 182: 1-11, 2004.
Barman, S.A., S. Zhu, and R.E. White. Protein kinase C inhibits BKCa channel activity in pulmonary arterial smooth muscle. Am. J. Physiol. 286: L149-L155, 2004.
Barman S.A., S. Zhu, and R.E. White. PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am. J. Physiol. 286: L1275-L1281, 2004.
Barman, S.A., and M.B. Marrero. Mechanism of endothelin-1 activation of MAP kinases in neonatal pulmonary vascular smooth muscle. Lung (In press)
White, R.E., G. Han, C. Dimitropoulou, S. Zhu, D. Fulton, K. Miyake, S. Dave, and S.A. Barman. Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle. Am. J. Physiol. 289: H1468-H1475, 2005.
Zhu, S., R.E. White, and S.A. Barman. Effect of PKC Isozyme Inhibition on Forskolin-Induced Activation BKCa Channels in Rat Pulmonary Arterial Smooth Muscle. Lung (In press)
Barman, S.A. Effect of nitric oxide on mitogen-activated protein kinases in neonatal pulmonary vascular smooth muscle. Lung 183: 325-335, 2005.
Barman, S.A., Zhu, S., and White, R.E. Hypoxia modulates cyclic AMP activation of BKCa channels in rat pulmonary arterial smooth muscle. Lung 183: 353-361, 2005.
Barman, S.A., S. Zhu, M.L. Meadows, and R.E. White. Protein kinase C inhibits cyclic adenosine monophosphate-induced calcium-activated and voltage-activated potassium channel activity in fawn-hooded rat pulmonary arterial smooth muscle via phosphodiesterases. Chest 128: 1, 2005
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