Current Research: Pediatric Hematology-Oncology

AREN03B2 -- Renal Tumors Classification, Biology, and Banking Study

The purpose of this research study is to classify patients with renal tumors by histological categorization, surgico-pathological stage, presence of metastases, age at diagnosis, tumor weight, and loss of heterozygosity for chromosomes 1p and 16q, and to define eligibility for a series of therapeutic studies. Secondary objectives for the trial include:

• Monitor outcome for those patients who are not eligible for a subsequent therapeutic study.
• Describe whether the pulmonary tumor burden correlates with outcome in patients with stage IV disease.
• Correlate the method of conception (natural vs assisted reproductive technology) with the development of Wilms' tumor.

Eligibility

Patients may be eligible for this trial if:

• Patients must be < 30 years old at the time of diagnosis
• Patients with tumors of the following histologic type are eligible for this study:
  • Nephroblastic tumors
    • Nephroblastoma (Wilms' tumor) (favorable histology, anaplasia [diffuse, focal])
    • Nephrogenic rests and nephroblastomatosis
    • Cystic nephroma and cystic partially differentiated nephroblastoma
    • Metanephric tumors (metanephric adenoma, metanephric adenofibroma, metanephric stromal tumor)
  • Mesoblastic nephroma (cellular, classic, mixed)
  • Clear cell sarcoma
  • Rhabdoid tumor (any malignant rhabdoid tumor occurring outside the CNS)
  • Renal epithelioid tumors of childhood (papillary renal cell carcinoma, medullary renal cell carcinoma, renal tumors associated with Xp11.2 translocations, oncocytic renal neoplasms after neuroblastoma)
  • Angiolipoma
  • Ossifying renal tumor of infancy

Trial Sponsor

• Children’s Oncology Group (COG); National Cancer Institute (NCI)

Project Begin Date

• Mar 2007

Tentative Project End Date

• Ongoing

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Revised March 30, 2009.   Please send comments, suggestions or questions about this page to Goldei Posey, gposey@mcg.edu .