Current Research: Pediatric Hematology-Oncology

AHOD0031 -- Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children With Newly Diagnosed Hodgkin's Disease

Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more cancer cells. Radiation therapy uses high-energy x-rays to damage cancer cells. It is not yet known if chemotherapy is more effective with or without additional chemotherapy and/or radiation therapy in treating Hodgkin's disease.

This randomized phase III trial is studying different chemotherapy regimens given with or without radiation therapy to compare how well they work in treating children with newly diagnosed Hodgkin's disease.

Eligibility

Patients may be eligible for this trial if:

• Less than 21 years of age
• Stage IB, IIB, or IA with bulk disease
• Patients with surgical staging (by laparotomy) alone are not eligible
• No prior chemotherapy or radiation therapy
• No corticosteroids within one month of enrollment

Trial Sponsor

• Children’s Oncology Group (COG); National Cancer Institute (NCI)

Project Begin Date

• Mar 2005

Tentative Project End Date

• Jun 2010

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Revised March 30, 2009.   Please send comments, suggestions or questions about this page to Goldei Posey, gposey@mcg.edu .