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Robert
W. Wrenn, Ph.D.,
rwrenn@mail.mcg.edu
Associate Professor: Department of Cellular Biology and Anatomy
Research Emphasis: Cellular regulation; molecular pathways of cellular regulation, especially involving protein phosphorylation. Protein kinase C as a cellular regulator.
Selected Publications:
Copland, J.; Hendry, L.; Chu, C.; Wood, J.; Wrenn, R.W.; Pantazis, C.;
Mahesh, V.B.; "Inhibition of estrogen stimulated
mitogenesis by 3-phenylacetylamino-2, 6-piperidinedione and its
para-hydroxy analog." Journal of Steroid Biochemistry and
Molecular Biology. 46:451 - 462, 1993.
Sickles, D.W.; Brady, S.; Wrenn, R.W.; Testino, A.; Friedman, M.; "Acrylamide
effects on kinesin-based microtubule
motility." (Abstract) Toxicologist. 15:211, 1995. (R)
Wrenn, R.W.; Herman, L.; Currie, M.; "Nitric oxide participates in
the regulation of pancreatic acinar cell secretion." Life
Sciences. 55:511 - 518, 1994. (R)
Munn, D.H.; Beall, A.; Song, D.; Wrenn, R.W.; Throckmorton, D.C.;
"Activation-induced apoptosis in human Mos:
Developmental regulation of a novel cell death pathway by MCSF and IFN-?."
Journal of Experimental Medicine. 181:127 -
136, 1995. (R)
Wrenn, R.W.; Herman, L.; "Integrin-linked tyrosine phosphorylation
increases membrane association of protein kinase CA in
pancreatic acinar cells." Biochemical and Biophysical Resarch
Communications. 208:978 - 984, 1995. (R)
Wrenn, R.W.; "Increased tyrosine phosphorylation of pancreatic acinar
cell cytosolic and membrane proteins following
ligation of A-integrin receptors." (Abstract) Molecular Biology of
the Cell. 5:62, 1994. (R)
Hannan, C.J.; Schoenlein, P.V.; Liang, Y.; Wrenn, R.W.; Shelton, W.W.;
"Magnetic field effects on P-gylcoprotein."
(Abstract) Annual Review of Research on Biological Effects of Electric and
Magnetic Fields from the Generation Delivery
and Use of Electricity. 1994:136 - 137, 1994. (R)
Hannan, C.J.; Liang, Y.; Schoenlein, P.V.; Wrenn, R.W.; Shelton, W.W.;
"Magnetic, not electric field inhibition of
multidrug resistance." (Abstract) American Association for Cancer
Research. 36:345, 1995. (R)
Meszaros, L.G.; Wrenn, R.W.; Varadi, G.; "Sarcoplasmic reticulum-associated
and protein kinase C-regulated adp-ribosyl
cyclase in cardiac muscle." Biochemical and Biophysical Research
Communications. 234:252 - 256, 1997. (R)
Dalton, M.; Gadson, P.F.; Wrenn, R.W.; Rosenquist, T.R.; "Homocysteine
signal cascade: production of phospholipids,
activation of protein kinase C and induction of c-fos and c-myb in
vascular smooth muscle cells." FASEB Journal. 11:703 -
711, 1997. (R)
Wrenn, R.W.; El Etreby, M.F.; Liang, Y.; Barrett, J.T.; Schoenlein, P.V.;
"Effects of antiprogestin, antiestrogen and
combination treatment on protein kinase C, DNA fragmentation and Bcl-2 in
two breast cancer model systems." (Abstract)
Molecular Biology of the Cell. 8:363a, 1997. (R)
Wrenn, R.W.; Herman, L.E.; "Integrin-linked tyrosine phosphorylation
increases membrane association of protein kinase
C@ in pancreatic acinar cells." Biochemical & Biophysical
Research Communications. 208:978 - 984, 1995. (R)
Sickles, D.W.; Brady, S.T.; Wrenn, R.W.; Testino, A.; Friedman, M.A.;
"Acrylamide effects on kinesin based microtubule
motility." (Abstract) The Toxicologist. 15:211, 1995. (R)
Wrenn, R.W.; "A1 Integrin-mediated tyrosine phosphorylation of
phospholipase C=1 in pancreatic acinar cells." (Abstract)
Molecular Biology of the Cell. 6:835a, 1995. (R)
Meszaros, L.G.; Wrenn, R.W.; Varadi, G.; "Protein kinase C-regulated
ADP-ribosyl cyclase activity in cardiac sarcoplasmic
reticulum." (Abstract) Biophysical Journal. 70:A53, 1996. (R)
Sickles, D.W.; Brady, S.T.; Testino, A.; Friedman, M.A.; Wrenn, R.W.;
"Direct effect of the neurotoxicant acrylamide on
kinesin-based microtubule motility." Journal of Neuroscience
Research. 34:153 - 164, 1996. (R)
Wrenn, R.W.; Creazzo, T.L.; Herman, L.E.; "A1 integrin ligation
stimulates tyrosine phosphorylation of phospholipase C=1
and elevates intracellular Ca3+ in pancreatic acinar cells."
Biochemical and Biophysical Research Communications. 226:876
- 882, 1996. (R)
Meszaros, L.G.; Wrenn, R.W.; Varadi, G.; "Protein kinase C-regulated
ADP-ribosyl cyclase activity in cardiac sarcoplasmic
reticulum." (Abstract) Biophysical Journal. 70:A53, 1996. (R)
Wrenn, R.W.; Creazzo, T.L.; "Increased tyrosine phosphorylation of
phospholipase C=1 and elevated [Ca3+]i following
A-integrin ligation in pancreatic acinar cells." (Abstract) Molecular
Biology of the Cell. 7:241a, 1996. (R)