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Dale
W. Sickles, Ph.D,Phone: (706) 721-7393/3913
Room: CB 1117A/1201
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Professor: Department of Cellular Biology and Anatomy
Research Emphasis: Neurotoxicology; molecular mechanisms of distal axonal degeneration; video microscopy, axonal transport, protein biochemistry and other neurobiological techniques.
Selected Publications:
Harris, C.H.; Gulati, A.K.; Friedman, M.A.; Sickles, D.W.; "Toxic
neurofilamentous axonopathies and fast transport. V.
Reduced bidrectional vesicle transport in cultured neurons by acrylamide
and glycidamide." Journal of Toxicology and
Environmental Health. 42:343 - 356, 1994. (R)
Harris, C.H.; Wrenn, R.A.; Friedman, M.A.; Sickles, D.W.; "Acrylamide
effects on cAMP-dependent MAP phosphorylation
and microtubule disassembly." (Abstract) Toxicologist. 14:206, 1994.
(R)
Sickles, D.W.; Friedman, M.A.; "Acrylamide reduces ATP-dependent
release of kinesin from microtubules." (Abstract) Toxicologist.
14:206, 1994. (R)
Rai, D.R.; Sickles, D.W.; Gulati, A.K.; "Immunogenecity of Schwann
cell populated acellular basal lamina nerve grafts."
(Abstract) Neuroscience Abstracts. 20:1070, 1994. (R)
Sickles, D.W.; Welter, D.A.; Friedman, M.A.; "Acrylamide arrests
mitosis and prevents chromosome migrations in to the
absence of changes in spindle microtubules." Journal of Toxicology
and Environmental Health. 44:73 - 86, 1995. (R)
Sickles, D.W.; Brady, S.; Wrenn, R.W.; Testino, A.; Friedman, M.; "Acrylamide
effects on kinesin-based microtubule
motility." (Abstract) Toxicologist. 15:211, 1995. (R)
Harris, C.H.; Gulati, A.K.; Friedman, M.A.; Sickles, D.W.; "Toxic
neurofilamentous axonopathies and fast anterograde
transport: V. Reduced bidirectional transport in cultured neurons by
acrylamide and glycidamide." Journal of Toxicology and
Environmental Health. 42:343 - 356, 1994. (R)
Sickles, D.W.; Pearson, J.K.; Testino, A.R.; Beall, A.; "Toxic axonal
degeneration occurs independent of neurofilament
accumulations." Journal of Neuroscience Research. 39:347 - 354, 1994.
(R)
Stone, D.; Peterson, A.P.; Eyer, J.; Sickles, D.W.; "Acrylamide and
gamma-diketones reduce fast axonal transport in the
absence of axonal neurofilaments." (Abstract) Toxicologist. 37:108,
1998. (R)
Sickles, D.W.; Tsai, N.; Padilla, S.; "Acrylamide produces a temporal
and correlative decrease in fast anterogradely
transported proteins in neuromuscular junctions." (Abstract)
Toxicologist. 37:107, 1998. (R)
Stone, D.; Sickles, D.W.; "Discrimination of molecular sites of
action of common neurotoxicants." (Abstract) Georgia
Research Symposium. , p. 12, 1998. (R)
Buccafusco, J.J.; Terry, A.; Sickles, D.W.; Hill, W.D.; Lanclos, K.;
Schoenlein, P.V.; "Organophosphate pesticide
intoxication association with memory deficits and inhibited neuronal
structure and function." (Abstract) Georgia Research
Symposium. , p. 10, 1998. (R)
Prendergast, M.A.; Milici, A.; Zhang, L.; Wei, J.; Sickles, D.W.;
Buccafusco, J.J.; "Estimation of vesicular acetylcholine
transporter mRNA by RT-PCR and HPLC.." (Abstract) Society
Neuroscience. 21:67, 1995. (R)
Sickles, D.W.; Brady, S.T.; Wrenn, R.W.; Testino, A.; Friedman, M.A.;
"Acrylamide effects on kinesin based microtubule
motility." (Abstract) The Toxicologist. 15:211, 1995. (R)
Clarke, C.H.; Sickles, D.W.; "Decreased GAP-43 accumulation in
neurite tips of cultured hippocampal neurons by
acrylamide." Neurotoxicology. 17:32 - 42, 1996. (R)
Sickles, D.W.; Brady, S.T.; Testino, A.; Friedman, M.A.; Wrenn, R.W.;
"Direct effect of the neurotoxicant acrylamide on
kinesin-based microtubule motility." Journal of Neuroscience
Research. 34:153 - 164, 1996. (R)
Sickles, D.W.; Tsai, J.; "2,5-Hexanedione directly affects kinesin-based
microtubule motility." (Abstract) The Toxicologist.
30:302, 1996. (R)
Stone, D.; Peterson, A.; Eyer, J.; Sickles, D.W.; "Acrylamide
neurotoxicity in a transgenic mouse model lacking axonal
neurofilaments." (Abstract) The Toxicologist. 30:301, 1996. (R)
Sickles, D.W.; "Neurofilamentous swellings and axonal atrophy are of
unclear significance to diketone toxicity."
Neurotoxicology. 18(1):33 - 36, 1997. (R)
Stone, D.; Peterson, A.; Eyer, J.; Sickles, D.W.; "Axonal
neurofilaments are not a critical site of action of =-diketones."
(Abstract) Toxicologist. 36:20, 1997. (R)
Sickles, D.W.; Abou-Donia, M.B.; "Effects of organophosphorus agents
on kinesin and microtubules in a motility assay."
(Abstract) Toxicologist. 36:21, 1997. (R)