Name:

Craig Brooks

Mentor:

Zheng Dong, Ph.D.

Year of Entry:

2003

Education:

B.S. Emmanuel College

Key Words:

Acute Ischemic Renal failure, apoptosis, renal injury, Bcl-2 proteins

Paragraph Describing Interests:

My research focus is the mechanisms of cell injury and cell death, especially the role of apoptosis in acute renal failure and the regulators of this process, such as Bcl-2 family proteins. Acute renal failure is a clinical syndrome associated with high mortality. Studies in the past few years have strongly suggested that apoptosis is involved not only in the injury but also the regeneration of tubular cells in acute renal failure. A better understanding of the regulation of apoptosis will not only lead to a better understanding of apoptosis in general, but also to therapeutic options.

Research Grants:

Publications:

Craig Brooks, Jinzhao Wang, Tianxin Yang and Zheng Dong. Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells.  American Journal of Physiology: Renal Physiology. 2007 Jan; 292(1): F243-52.

Craig Brooks, Pimonrat Ketsawatsomkron, Sui Yang, Jinzhao Wang, Zheng Dong.  Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome.  American Journal of Physiology: Renal Physiology. 2005 Aug; 289(2):F410-9.

Craig Brooks, Jinzhao Wang, and Zheng Dong. Acidotic pH inhibits tubular cell apoptosis following ATP-depletion by blocking caspase activation in apoptosome. Abstract. American Society of Nephrology National meeting. St. Louis, MO. 2004.

Craig Brooks, Pimonrat Ketsawatsomkron, Sui Yang, Jinzhao Wang, Zheng Dong. Acidic pH Inhibits ATP depletion-induced Tubular Cell Apoptosis by Blocking Caspase-9 Activation in Apoptosome. American Journal of Physiology. Ahead of print.