My research interest is in the regulatory mechanisms of pulmonary circulation and lung injury and repair. The focus is on three areas: protein-protein interaction in lung endothelial signaling, calpain in hypoxic pulmonary vascular remodeling and angiogenesis, and lung injury and repair in tobacco smoke exposure. Through multidisciplinary approaches at the levels of molecule, cell, organ, and whole body, the goal is to find novel therapeutic strategies and biomarkers for pulmonary hypertension, chronic obstructive pulmonary diseases (COPD), and cor pulmonale.
1. eNOS-actin Interaction and Oxygen in Lung Endothelium (# HL088261)
Funding agency: NIH (R01)
Amount (direct cost): $1,250,000 (7/1/2008-6/30/2013)
The major goal of this study is to investigate hypothesis that eNOS-actin association results in increased catalytic activity and that alterations in eNOS-?-actin interaction mediate the regulation of eNOS function in lung endothelium exposed to different oxygen tensions.
Role in the project: Principal Investigator
2. Calpain Mediates VEGF-induced Collagen Synthesis in Pulmonary Vascular Cells (# 0855338E)
Amount (direct cost): $165,000 (07/01/2008-06/30/2010)
Funding agency: AHA Greater Southeast Affiliate
The major goals of this study are to determine hypothesis that calpain regulates VEGF-induced collagen synthesis in pulmonary vascular cells.
Role in the project: Principal Investigator
3. Nitric Oxide and Side-Stream Tobacco Smoke Modification of Calpains in Airway Epithelial Repair
(# 072104_CIA)
Funding agency: Flight Attendant Medical Research Institute (National)
Amount (direct cost): $300,000 (7/1/2008-6/30/2011)
The major goal of this study is to investigate hypothesis that calpains mediate airway epithelial repair and that calpain inhibition is responsible for side-stream tobacco smoke- and nitric oxide-induced impairment of airway epithelial repair.
Role in the project: Principal Investigator
Hand-held Analyzer for Detecting Exposure to Secondhand Smoke.
Funding agency: Flight Attendant Medical Research Institute (National)
Amount (direct cost): $300,000 (7/1/2009-6/30/2012)
Role in the project: collaborator (2.5%)
Dmitry Kondrikov - Research Assistant Scientist
Wendy Han - Research Associate
TBA: Two Postdoctoral Researchers are needed.
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2004 and 2008 - Clinical Innovator Award, Flight Attendant Medical Research Institute.
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2004 - Career Investigator Award, American Lung Association of Florida.
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2001 - Young Investigator Award, Florida Department of Health.
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2001 - present - Journal Reviewer for American Journal of Pathology, Journal of Investigative Medicine, PLoS ONE, European Respiratory Journal , Lung, FEBS LETTERS, Vascular Pharmacology, Biochemical Pharmacology, International Journal of Experimental Pathology, Medical Science Monitor, Experimental Lung Research, Human and Experimental Toxicology, Chemical Research in Toxicology, Advances in Experimental Biology (Book)
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2001-present - Grant Reviewer Committee for AHA's Lung, Respiration and Resuscitation
Committee, Kentucky Science & Engineering Foundation, Flight Attendants Medical
Research Institute, Health Research Board of Ireland
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1990 - Postgraduate Excellence Awards in Tongji Medical University, China.
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1985 - Top 2% in the class of 1985 in Tongji Medical University, China.
Calpain-2 Regulation of VEGF-Mediated Angiogenesis. The 2007 FASEB Summer Research Conference, The Biology of Calpain in Health and Disease, Snowmass Village, Colorado, July 14--19, 2007.
Cytoskeletal Regulation of Endothelial Nitric Oxide Synthase in Hyperoxic Pulmonary Artery Endothelial Cells. The 5th International Congress of Pathophysiology, Beijing, China, June 28-July 1, 2006
Novel Mechanism for Endothelial Regeneration and Angiogenesis. The Second Symposium of Science, Engineering, and Biomedicine, Clearwater Beach, Florida, September 3, 2005.
Cigarette Smoke Inhibits Lung Angiogenesis Novel Mechanism for Cigarette Smoke-induced Emphysema. The fourth Scientific Symposium of Flight Attendant Medical Research Institute, Miami Beach, FL 33140, May 11-13, 2005.
Calpain Functions in Angiogenic Effect of VEGF in vitro. FASEB Summer Research Conferences --- Biology of the Calpains in Health and Disease, Tucson, Arizona, June 7-12, 2004.
The role of Hsp90 in hypoxia-induced inhibition of nitric oxide synthase in pulmonary artery endothelial cells. 2000 American Thoracic Society International Conference. Toronto, Antonio, Canada, May 5-11, 2000.
Han W, Kamal A. Mohammed, Su Y (Corresponding author). α-defensin increases lung fibroblast proliferation via Wnt/β-catenin pathway. 2009; Biochem.Biophys.Res.Commun. submitted.
Su Y (Corresponding author), Kondrikov D, Block ER. beta-actin: a regulator of NOS-3. Science STKE 2007;2007(404):e52-1-e52-3.
Najmunnisa N, Mohammed KA, Brown S, Su Y, Sriram PS, Moudgil B, Loddenkemper R, Antony VB. Talc mediates angiostasis in malignant pleural effusions via endostatin induction. Eur.Respir.J. 2007; 29(4):761-9.
Qiu, K., Su, Y. (Corresponding author), and Block, E.R. Use of recombinant calpain-2 siRNA adenovirus to assess calpain-2 modulation of lung endothelial cell motility and proliferation. Molecular and Cellular Biochemistry 2006; 292(1-2):69-78.
Su, Y (Corresponding author), Cui, Z., Li, Z., and Block, E.R. Calpain-2 regulation of VEGF-mediated angiogenesis. FASEB Journal 2006, 20(9):1443-1451.
Kondrikov D, Han HR, Block ER, Su Y (Corresponding author). Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 2006; 290(1):L41-L50.
Su Y (Corresponding author), Zhang J, Patel JM, Antony V, Block ER. Concentration-dependent effects of nitric oxide on angiogenesis of lung microvascular endothelial cells: role of calpain nitrosylation. Proc Am Thorac Soc. 2006;3:548-549.
Cui Z, Han Z, Li Z, Hu H, Patel JM, Antony V, Block ER, Su Y. Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial NOS. Am J Respir Cell Mol Biol 2005; 33(5):513-520.
Su, Y. (Corresponding author), Kondrikov, D. and Block, E.R. Cytoskeletal regulation of nitric oxide synthase. Cell Biochemistry and Biophysics 2005; 43:439-449.
Su, Y. (Corresponding author), Cao, W., Han, Z., Block, E.R. Cigarette smoke extract inhibits angiogenesis of pulmonary artery endothelial cells (PAEC) ? Role of calpain. American Journal of Physiology Lung Cell Mol Physiol. 2004; 287:L794-L800.
Wang, C-Y., Shi, J-D., Yang, P., Kumar, P.G., Li, Q-Z., Run, Q-G., Su, Y., Scott, H.S., Kao, K-J., She, J-X., Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP), Gene 2003; 306:37-44.
Su, Y. (Corresponding author), Sophia Edwards-Bennett, Michael R. Bubb, Edward R. Block. Regulation of endothelial nitric oxide synthase by the actin cytoskeleton, American Journal of Physiology Cell Physiology, 2003; 284 (6):C1542-C1576.
Su, Y. (Corresponding author), Sergei, Z. & Block, E.R. Microtubule active agents modify nitric oxide synthase activity in pulmonary artery endothelial cells. American Journal of Physiology. 2002; 282:L1183-L1189 (EDITORIAL FOCUS).
Su, Y. & Block, E.R. Effect of calpain on nitric oxide synthase in pulmonary artery endothelial cells during hypoxia. American Journal of Physiology. 2000; 278:L1204-L1212.
Su, Y. & Block, E.R. Phenylarsine oxide inhibits nitric oxide synthase in pulmonary artery endothelial cells. Journal of Free Radical Biology and Medicine. 2000; 28(2):167-173.
Su, Y. Couch M. & Block, E.R. Substrate inhibition of NO synthase in pulmonary artery endothelial cells in culture. Nitric Oxide: Biology and Chemistry. 1997; 1(6):469-475.
Su, Y. Han, W. Girado, C. Li, Y.D. & Block, E.R. Effect of cigarette smoking extracts on NO synthase in pulmonary endothelial cells. American Journal of Respiratory Cell and Molecular Biology. 1998; 19(5):819-825.
Su, Y. & Block, E.R. Effect of hypoxia on the induction of argininosuccinate synthetase and NO synthase in pulmonary endothelial cells. American Journal of Physiology. 1997; 272(Lung Cell. Mol. Physiol. 16):L934-938.
Maria A. Moro, Rachel J. Russell, Selim Cellek, Ignacio Lizasoain, Yunchao Su, Victor M. Darley-Usmar, Marek W. Radomski, & Salvador Moncada. cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase. Proceeding of National Academy of Science of USA. 1996; 93:1480-1485.
Su, Y. (Corresponding author) & Block, E.R. Acute hypoxia increases intracellular arginine content in pulmonary endothelial cells. Journal of Cellular Physiology. 1996; 167(2):349-353.
Su, Y. & Block, E.R. Hypoxia inhibits arginine synthesis in pulmonary artery endothelial cells. American Journal of Physiology. 1995; 269:L581-L587.
Maria Angeles Moro, Victor M. Darley-Usmar, Ignacio Lizasoain, Yunchao Su, Richard G Knowles, Marek W Radomski, & Salvador Moncada. The formation of nitric oxide donors from peroxynitrite. British Journal of Pharmacology. 1995; 116:1999-2004.
Yunchao Su (Corresponding author), and Edward R. Block, Pulmonary Endothelium and Nitric Oxide. The Pulmonary Endothelium edited by Sharon Rounds and Norbert Voelkel, John Wiley and Sons, Ltd, 2008.
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