Phone: (706) 721-7649
Fax: (706) 721-2347

Email: rrudic@mail.mcg.edu

Office: CB-3620

Grant Support as Principal Investigator | Current Projects | Lab | Honors & Awards | Selected Publications |

The cardiovascular system behaves rhythmically over the course of a day, coordinating tissue perfusion in accordance with oscillating metabolic and functional demands. These oscillations, which occur in blood vessels as variations in contractility and blood pressure, follow a distinctive temporal pattern-a circadian rhythm. Aberrations to circadian rhythm meet with pathological consequences. Shift work or even aberrations to the circadian rhythm in blood pressure increase the risk of cardiovascular disease. In addition, the onset of acute vascular events such as myocardial infarction and stroke also exhibit circadian variation. Our laboratory is interested in examining the contribution of the circadian clock-a unique collaboration of genes and proteins that comprise the essence of circadian rhythms-in vascular cell signaling and disease

The biological clock, the endothelium, and vascular remodeling
PI: R. Daniel Rudic, Ph.D.
Type: NIH R01-HL089576
Period: 8/01/08 - 7/31/13


Peripheral clocks in metabolism and diabetes
PI: R. Daniel Rudic, Ph.D.
Type: NIH K01-DK070658
Period: 12/12/05-04/01/2010

• Circadian clock in vascular remodeling and injury.
• Circadian regulation of vascular signaling.
• Endothelial control of the circadian clock.

Ciprian Anea, MD - Post-doctoral fellow
Maoxiang, Zhang, PhD - Post-doctoral fellow
Bo Cheng, PhD - Post-doctoral fellow
Paramita Pati - Graduate Student
Ana Merloiu - Research Assistant

Lab Website

• 2004 - ATVB Irvine Page Young Investigator Award Finalist
• 2003 - ATVB New Investigator Travel Award
• 2002 - American Heart Association Post-Doctoral Fellowship
• 2000 - NRSA Post-Doctoral Fellowship
• 1987-1991 - Outstanding Achievement Scholarship, Temple University

Anea CB, Zhang M, Stepp DW, Simkins GB, Reed G, Fulton DJ, Rudic RD. Vascular disease in mice with a dysfunctional circadian clock. Circulation 2009; 119:1510-1517.

Zhang Q, Malik P, Pandey D, Gupta S, Jagnandan D, Belin de Chantemele E, Banfi B, Marrero MB, Rudic RD, Stepp DW, Fulton DJ. Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase. Arterioscler Thromb Vasc Biol. 2008;28:1627-1633.

Zemse SM, Hilgers RH, Simkins GB, Rudic RD, Webb RC. Restoration of endothelin-1-induced impairment in endothelium-dependent relaxation by interleukin-10 in murine aortic rings. Can J Physiol Pharmacol. 2008;86:557-565.

Reilly DF, Curtis AM, Cheng Y, Westgate EJ, Rudic RD, Paschos G, Morris J, Ouyang M, Thomas SA, FitzGerald GA. Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling. Arterioscler Thromb Vasc Biol. 2008;28:121-126.