Epilepsy Research

www.synapses.mcg.edu
Investigating the structural basis of synaptic function in:
- Brain Development
- Synaptic Plasticity
- Recovery from Insult
- Mental Retardation and Neuropathology

December 2005 American Epilepsy Society presentation:  Relation between Subclinical Seizures and Focus Location in Adults Implanted with a Responsive Neurostimulator

Automated Response to Spontaneous Epileptiform Activity using the External Responsive Neurostimulator System

Prospective Seizure Frequency Clinical Investigation

An Assessment of Behavioral Changes Associated with Lamotrigine and Levetiracetam in Patients with Epilepsy

A Double-blind, Randomized, Two Period Crossover Comparison of the Cognitive and Behavioral Effects of Levetiracetam and Carbamazepine in Healthy Adults

Understanding the Pathophysiology of Brain Tumors: The relationship of Intracerebral Glial Tumors, Epilepsy, and Neuronal Plasticity

Research Studies 

Automated Response to Spontaneous Epileptiform Activity Using the External Responsive Neurostimulator System

Responsive Neurostimulator (RNS) System Feasibility Clinical Investigation

Responsive Neurostimulator (RNS) System Pivotal-A Clinical Investigation

Responsive Neurostimulator (RNS) System Long-Term Clinical Investigation

A Double-Blind, Randomized, Multicenter, Placebo-Controlled, In-Patient, Maximum 34 Day Study of Levetiracetam Oral Solution (20-50 mg/kg/day) as Adjunctive Treatment of Refractory Partial Onset Seizures in Pediatric Epileptic Subjects Ranging in Age from 1 Month to Less Than 4 years of Age

A 19-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Safety Study to Evaluate the Cognitive and Neuropsychological Effects of Levetiracetam 20-60mg/kg/day, Divided in Twice Daily Dosing, as Adjunctive Treatment in Children 4-16 Years Old, Inclusive, With Refractory Partial Onset Seizures

A Multi-Center, Open-Label, Long-Term Follow-up Study of the Safety and Efficacy of Levetiracetam in Children with Partial Onset Seizures

 A Randomized, Open-Label , Multicenter Study With Open-Label Extension of the Pharmacokinetics and Safety of Topiramate Administered as the Oral Liquid and Sprinkle Formulations as an Adjunct to Concurrent Anticonvulsant Therapy in Infants (Aged 1 to 23 Months, Inclusive) with Refractory Partial Onset Seizures

A Randomized, Double-Blind, Placebo-Controlled, Fixed Dose-Ranging Study to Assess the Safety, Tolerability, and Efficacy of Topiramate Oral Liquid and Sprinkle Formulations as an Adjunct to Concurrent Anticonvulsant Therapy for Infants (1 to 23 Months of Age, Inclusive) With Refractory Partial-Onset Seizures, With Open-Label Extension

If you are interested in one of these studies, please call Patty Ray, PhD at 706-721-6260

Abstracts

2005

American Epilepsy Society 58th Annual Meeting at Washington, DC.  December 2-6, 2005.  Park YD, Esteller R, Murro AM, Politsky J, Lee KH, Ray P, Smith JR. Relation between Subclinical Seizures and Focus Location in Epileptic Patients Implanted with a Responsive Neurostimulator.

American Epilepsy Society 58th Annual Meeting at Washington, DC.  December 2-6, 2005.  Politsky J, Esteller R, Murro AM , Smith JR, Ray P, Park YD, Morrell MJ. Effects of Electrical Stimulation Paradigm on Seizure Frequency in Medically Intractable Partial Seizure Patients with a Cranially Implanted Responsive Cortical Neurostimulator.

American Epilepsy Society 58th Annual Meeting at Washington, DC.  December 2-6, 2005.  Founyas KN, Smith JR, Murro AM, Politsky J, Park YD, Jenkins PD, Greene D. Closed-loop Stimulation Implantable System for the Management of Focal, Medically Refractable Epilepsy: Implantation Technique and Preliminary Results.

26th International Epilepsy Congress at Paris, France.  August 28 - September 1, 2005.  Park YD, Esteller R, Murro AM, Politsky JM, Lee KH, Ray P, Smith JR.  Epilepsy Outcome Improved Following Responsive Neurostimulator Treatment.

14th Meeting of the World Society for Stereotactic and Functional Neurosurgery at Rome, Italy.  June 14-17, 2005.  Smith J, Murro A, Politsky J, Park Y, Fountas K, Jenkins P, Green D and Esteller R.  Closed-Loop Stimulation in the Control of Focal Epilepsy.

2004

International Neuropsychological Society Annual Meeting.  Lee, G.P., Westerveld, M., Hempel, A., Blackburn, L.B., Park, Y.D., and Loring, D.W.  Low presurgical IQ predicts poor seizure outcome after epilepsy surgery in children. Journal of the International Neuropsychological Society.

American Society of Neuroradiology Annual Meeting at Phoenix AZ, Jan. 2004.  Kim H, Park YD, Lee KH, King DW, Murro AM, Lee MR. Pathophysiology of Clustering Complex Partial Seizures; Subtraction Ictal SPECT Coregistration to MRI (SISCOM) Study

American Academy of Neurology Annual Meeting at San Francisco, CA. April 24-May 1, 2004.  Hyunmi Kim, Yong D. Park, Ki Hyeong Lee, Anthony M. Murro, Mark R. Lee, Joseph R. Smith.  Extratemporal Lobe Epilepsy in Children: Clinical, Neurophysiologic Features and 1-Year Surgical Outcome

Ki Hyeong Lee, Yong D. Park, Mark R. Lee, Joseph R. Smith, Kimford J. Meador. Prognostic Value of Secondary Hyperperfusion in the Temporal Lobe Contralateral to the Seizure Focus in Patients with Temporal Lobe Epilepsy – Subtraction SPECT Study

The 90th Scientific Assembly and Annual Meeting of the Radiological Society of North America, December 1, 2004.  Pillai JJ, Williams HT, Chen FK, Politsky J, Lee KH, Park YD. Comparison of Diagnostic Utility of PET/CT, SPECT, and Structural MRI in Temporal Lobe Epilepsy.

American Epilepsy Society 58th Annual Meeting at New Orleans, Dec. 3-7, 2004
Park YD, Lee H, Lee MR. Substraction ictal SPECT co-registratered to MRI in children with tuberous sclerosis complex: correlation with intracranial EEG.

Lee KH, Park YD, Murro AM, Politzky JM, Lee MR, Smith JR. Prognostic implication of secondary hyperperfusion in the temporal lobe contralateral to the seizure focus in patients with temporal lobe epilepsy: Subtraction SPECT study.

Liu Z, Park YD, Hessler R, Lee MR, Lee KH, Smith JR, Murro AM, King DW. Temporal lobectomy in children with medically intractable epilepsy: neuropathology, clinical features and seizure outcome.

Lee GP, Westerveld M, Blackburn LB, Park YD, Loring DW. Anomalous language representation protects against verbal memory decline after left hemisphere epilepsy surgery in children.

2003

American Epilepsy Society 57th Annual Meeting at Boston, MA, Dec. 5-10, 2003.  Lee, G.P., Park, Y.D., Blackburn, L.K., Loring, D.W., and Cohen, M.J. Wada testing predicts material-specific memory decline after epilepsy surgery in children.

Kim H, Park YD, Lee KH, Murro AM, Politsky J, Lee MR. Clinical and electrographic features and postoperative outcome of clustering seizures.

Politsky J,M., Murro AM, Park YD, Lee KH, Lee MR, Pillai JJ, Smith JR. The impack of SISCOM data regarding surgical planning and understanding the spread of neuronal activity in intractable epilepsy patients.

Murro AM, Park YD, Politsky J, Smith JR, Lee MR. Sensitivity and limitations of prolonged EEG-video monitoring.

Murro A, Park Y, Bergey G, Kossoff E, Ritzl E, Karceski S, Flynn K, Choi H, Spencer D, Duckrow R, Seale C. Multicenter study of acute responsive stimulation in patients with intractable epilepsy.

2002

American Clinical Neurophysiology Society Annual Meeting at new Orleans, LA, Sept. 20-21, 2002.  Murro AM, Park YD, Greene D, Smith JR, Ray P, King DW, Loring DW, Lee KH. Closed loop neurostimulation in patient with intractable epilepsy. J Clinical Neurophysiology 2003, 20:222

American Epilepsy Society Annual Meeting at Seattle, WA, Dec. 6-11, 2002.  Loring DW, Meador KJ, Lee GP, Murro A, Park, YD, King DW, Lee K, Lee M, Smith JR. Baseline neuropsychological memory performance and Wada memory are independent predictors of memory change following left anterior temporal lobectomy.

Lee GP, Park YD, Hempel A, Westerveld M, Loring DW. Wada memory performance predicts degree of seizure relief after epilepsy surgery in children.

Lee KH, Park YD, King DW, Meador KJ, Smith JR. False localizing ictal SPECT – clinical and neurophysiological analysis.

Park YD, Lee KH, King DW, Lee MR, Smith JR. Substraction ictal SPECT coregistered to MRI (SISCOM) in presurgical evaluation of children with intractable epilepsy.

University of Texas Medical School-Houston, Epilepsy Surgery Center Conference on the use of magnetic source imaging in epilepsy surgery, Houston, TX, 2002 (November)  Smith JR, King DW, Park YD, Lee GP, Jenkins PD. A 10-year experience in the utilization of magnetic source imaging in the guidance of epilepsy surgery.