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Related Publications
Primary Papers
Adams RJ, McKie VC, Brambilla DJ, Carl E, Gallagher D, Nichols FT, et al.
Stroke prevention trial in sickle cell anemia. Controlled Clinical Trials
1998;19(1):110-129.
Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al.
Prevention of a first stroke by transfusions in children with sickle cell
anemia and abnormal results on transcranial Doppler ultrasonography. The New
England Journal of Medicine 1998;339(1):5-11.
Files B, Kutlar A, Adams R, Vichinsky V, Wang W, Brambilla B. Longitudinal
changes in ferritin during chronic transfusion: A report from the stroke
prevention trial in sickle cell anemia (STOP). Journal of Pediatric
Hematology/Oncology 2002;24(4):284-290.
Hsu LL, Miller ST, Kutlar A, Wright E, Wang W, Pegelow CH, et al., for the
Stroke Prevention Trial (STOP) and the Cooperative Study of Sickle Cell
Disease (CSSCD). Alpha thalassemia is associated with decreased risk of
abnormal TCD in children with sickle cell anemia. Journal of Pediatric
Hematology/Oncology 2003;25(8):622-628.
Miller ST, Berman B, Files B, Hurlet A, Scher C, Abboud M, et al. Impact of
chronic transfusion on incidence of pain and acute chest syndrome during the
stroke prevention trial in sickle cell anemia (STOP). Journal of Pediatrics
2001;139(6):785-789.
Pegelow CH, Wang W, Granger S, Hsu LL, Vichinsky E, Moser FG, et al. Silent
infarcts in children with sickle cell anemia and abnormal cerebral artery
velocity. Archives of Neurology 2001;58:2017-2021.
Vichinsky E, Luban N, Wright E, Olivieri N, Driscoll C, Pegelow C, Adams RJ
for the STOP Study Investigators. Prospective RBC phenotype matching in a
stroke prevention trial in sickle cell anemia: A multi-center transfusion
trial. Transfusion 2001;41:1086-1092.
Wang WC, Gallagher DM, Pegelow CH, Wright EC, Vichinsky EP, Abboud MR, et
al. A multi-center comparison of magnetic resonance imaging and transcranial
Doppler ultrasonography in the evaluation of the central nervous system in
children with sickle cell disease. American Journal of Pediatric
Hematology/Oncology 2000;22:335-339
Abboud M, Cure J,
Gallagher D, Berman B, Hsu L, Wang W, Woods G, Zimmerman R, Brambilla D,
Lewin J, Adams R. for the STOP Investigators.Magnetic resonance andiography
(MRA) in children with abnormal transcranial Doppler (TCD) velocities in the
“STOP” study.
Status: Accepted by Blood, January 16, 2004.
STOP-Related Publications
Bulas DI, Jones A, Siebert JJ, Driscoll C, O?Donnell R, Adams RJ.
Transcranial Doppler (TCD) screening prevention in sickle cell anemia:
Pitfalls in technique variation. Pediatric Radiology 2000;30:733-738.
Cheung TW, Harmatz P, Lubin B, Larkin E, Adams RJ, Wun T, et al.
Demonstration of large and small vessel cerebrovascular disease in sickle
cell anemia (SCA) by transcranial Doppler (TCD) and bulbar conjunctival
intravital microscopy. Proceedings of the American Society of Hematology
39th Annual Meeting, San Diego, CA: Blood (supplement) 1997:90(10);1997.
Jones AM, Siebert JJ, Nichols FT, Kinder DL, Cox K, Luden J, et al.
Comparison of transcranial color Doppler imaging (TCDI) and transcranial
Doppler (TCD) in children with sickle cell anemia. Pediatric Radiology
2001;31:461-469.
Nichols FT, Jones AM, Adams RJ. Stroke prevention in sickle cell disease
(STOP) study guidelines for transcranial Doppler testing. Journal of
Neuroimaging 2001;11:354-362.
Adams RJ, McKie VC, Nichols FT,
Carl EM, Zhang DL, McKie K, Figueroa R, Litaker M, Thompson W, Hess DC. The
Use of Transcranial Ultrasonography Tp Predict Stroke in Sickle Cell
Disease. N.Engl J Med April 1992; 326(9): 605-610.
Adams RJ, McKie VC, Carl EM, Nichols DT, Pery R, Brock K, McKie K, Figueroa
R, Litaker M, Weiner S, Brambilla DJ. Long Term Stroke Risk in Children With
Sickle Cell Disease Screened with Transcranial Doppler. Ann Neurol 1997;
42(5):699-704.
Adams RJ, Pavlakis S, Roach ES. Sickle cell disease and stroke: primary
prevention and transcranial Doppler. Ann Neurol 2003 Nov; 54(5):559-563.
Selected Abstracts
Blood Transfusion
Files B, Brambilla D, Kutlar A, Miller S, Pegelow C, Vichinsky E, et al. A
randomized trial of chronic transfusion to prevent stroke in sickle cell
anemia: Changes in ferritin with chronic transfusion. Blood 1998;92(10)
(Suppl.1), p. 528a.
Miller ST, Wright E, Abboud M, Berman B, Files B, Scher C, et al. Impact of
chronic transfusion on non-neurological events during the stroke prevention
trial in sickle cell anemia (STOP). Proceedings of the 24th Annual Meeting
of the NSCDP, April 2000; p61a.
Olivieri N, Brambilla D, McKie V, Piomelli S, Kutlar A, Files B, et al.
Changes in cerebral blood flow velocities during chronic transfusion therapy
to prevent stroke in sickle cell disease. Blood 2000;96:486a.
Vichinsky E, Luban N, Wright E, Olivieri N, Driscoll C, Pegelow C, Adams RJ,
and the STOP Investigators. Prospective red cell phenotype matching in STOP:
A multi-center transfusion trial. Proceedings of the 23rd Annual Meeting of
the NSCDP, March 1999; p. 163.
Vichinsky E, Luban N, Wright E, Olivieri N, Driscoll C, Pegelow C, et al.
Prospective red cell phenotype matching in STOP: A multi-center transfusion
trial. Blood 1998;92(10) (Suppl.1), p. 528a.
Wang WC, Morales K, Adams R, Brambilla D. Effect of chronic transfusion on
growth in children with sickle cell anemia: Results of the STOP trial.
Proceedings of the 30th Meeting of the NSCDP and the SCDAA, Washington DC,
September 2002.
General Study Information
Carl E, Odo N, Poplick H, Luden J, Vinella M, Adams R. Ensuring informed
consent document consistency in a multicenter trial. Proceedings of the 25th
Annual Meeting of the NSCDP, New York, April 2001.
Odo N, Carl E, Gallagher D, Adams R. Dissemination of findings to trial
participants, physicians, and others. Proceedings of the 25th Annual Meeting
of the NSCDP, New York, April 2001.
Yong M, Antonelli TA, Gallagher D. Does submission of source documents
improve data quality? Controlled Clinical Trials 2000;21 (2S):92S.
Laboratory Findings
Hoppe C, Klitz W, Trachtenberg E, Cheng S, Grow M, Silbergleit A, et al. HLA
and TNFa polymorphisms predict stroke risk in children with sickle cell
anemia: Confirmation from the Stroke Prevention Trial (STOP). Blood
2000;96:8a.
Kutlar A, Harbin J, Jackson BB, Holley L, Gallagher D, Clair B. Baseline
laboratory parameters in patients randomized to the STOP study and their
modification by transfusion. Proceedings of the 24th Annual Meeting of the
NSCDP, April 2000; p82a.
Kutlar A, Harbin J, Jackson B, Holley L, Gallagher D, Clair B, et al.
Laboratory parameters in patients randomized to the STOP study and their
modification by transfusion. Blood 2000;96:18b.
Lee SB, Ramsingh D, Kutlar A, Holley L, McKie VC, Adams RJ for the STOP
Study Investigators. C-reactive protein in children with sickle cell disease
at risk for stroke in the STOP Study. Proceedings of the 27th International
Stroke Conference American Heart Association, San Antonio, TX, February
2002.
STOP Study Results
Adams RJ, Brambilla D, McKie V, Files B, Vichinsky E, Abboud M, et al.
Stroke prevention in sickle cell disease (STOP): Follow up after closure of
the trial. Blood 1998;92(10) (Suppl.1), p. 527a.
Adams R, Brambilla D, McKie V, Files B, Vichinsky E, Abboud M, et al. Stroke
prevention in sickle cell disease (STOP): Final results. Proceedings of the
25th Annual Meeting of the NSCDP, New York, April 2001.
Stroke Risk/TCD
Abboud MR, Cure J, Gallagher D, Berman B, Hsu L, Wang W, et al. Magnetic
resonance angiography in children with abnormal TCD in the STOP study.
Proceedings of the 23rd Annual Meeting of the NSCDP, March 1999; p. 49.
Adams R, Abboud M, McKie V, Scher C, Gallagher D, Nichols F, et al. TCD in
sickle cell disease (SCD): Focal vs. generalized velocity as an indicator of
stroke risk. Proceedings of the 25th Annual Meeting of the NSCDP, New York,
April 2001; p. 7.
Adams R, Brambilla D, Vichinsky E, Abboud M, Pegelow C, Carl E, et al.
Stroke prevention trial in sickle cell anemia (STOP study): Risk of stroke
in 1933 children screened with transcranial Doppler (TCD). Proceedings of
the 23rd Annual Meeting of the NSCDP, March 1999; p. 54.
Adams RJ, Brambilla D, McKie V, Files V, Vichinsky E, Abboud M, et al. Risk
of stroke in children with sickle cell disease and abnormal transcranial
Doppler ultrasound (TCD). Blood 1999;94:419a.
Adams RJ, Brambilla D, Vichinsky E, Abboud M, Pegelow C, Carl EM, et al.
Risk of stroke and conversion to abnormal TCD in children screened with
transcranial Doppler (TCD) during the STOP study. Proceedings of the 30th
Meeting of the NSCDP and the SCDAA, Washington DC, September 2002.
Adams RJ, Carl EM, Jones AM, Nichols FT, Brambilla D, Gallagher D, et al.
Transcranial Doppler in sickle cell disease: Comparison of systolic and
diastolic to mean velocities for stroke prediction. Proceedings of the 24th
Annual Meeting of the NSCDP, April 2000; p78a.
Brambilla DJ, Nichols FT, Abboud M, Adamkiewicz T, Berman B, Carl E, et al.
Reproducibility of transcranial Doppler ultrasound in children with sickle
cell disease. Proceedings of the 24th Annual Meeting of the NSCDP, April
2000; p79a.
Hess DC, Adams RJ, Nichols FT, Carl EM, Stephens S. Transcranial Doppler:
Analysis of pulsatility index in patients with cerebrovascular disease.
Neurology 1989;39(1):186.
Hetherington R, Olivieri N, Bookstein F, Pichard E. Cerebrovascular blood
flow is related to cognitive performance in sickle cell disease: A partial
least squares analysis. Journal of the International Neuropsychological
Society 1999;5:154.
Hsu L, Miller S, Kutlar A, Wright E, Driscoll C, Wang W, et al., for the
Stroke Prevention Trial (STOP) and the Cooperative Study of Sickle Cell
Disease (CSSCD). Does alpha thalassemia influence the frequency of
transcranial Doppler ultrasonography (TCD) abnormalities in children with
sickle cell disease? Proceedings of the 23rd Annual Meeting of the NSCDP,
March 1999; p. 102.
Hsu LL, McKie V, Wright E, Miller S, Kutlar A, Driscoll C, et al. Alpha
thalassemia is associated with higher odds for normal transcranial Doppler (TCD)
after adjustment for Hb and MCV. Proceedings of the 24th Annual Meeting of
the NSCDP, April 2000; p77a.
Pegelow CH, Adams RJ, Hsu L, McKie VM, Zimmerman R, Bello J, et al., for the
Stroke Prevention in Sickle Cell Anemia (STOP) Group. Children with silent
infarct and elevated transcranial Doppler ultrasonography velocity are at
increased risk of subsequent infarctive events. Proceedings of the 23rd
Annual Meeting of the NSCDP, March 1999; p. 137.
Tillman I, Poplick H, Granger S, Brambilla D, Adams, RJ for the STOP Study
Investigators. Correlation of stroke risk in siblings based on TCD
velocities. Proceedings of the 30th Meeting of the NSCDP and the SCDAA,
Washington DC, September 2002.
NSCDP = National Sickle Cell Disease Program
SCDAA = Sickle Cell Disease Association of America