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Lin Mei, M.D./Ph.D.
E-mail: lmei@mcg.edu
Research Emphasis:
We are interested in molecular mechanisms underlying the formation and
maintenance of synapses. Our goal is to identify targets to develop
therapeutic strategies for treating neurological disorders including spinal cord
injury, neuromuscular disorders, epilepsy and psychiatric disorders such as
schizophrenia.
Selected Publications
Y.Z. Huang, S.S. Won, D.W. Ali, Q. Wang, M. Tanowitz, Q.S. Du, W.C.
Xiong, K.A. Pelkey, M.W. Salter, and Lin Mei. Regulation of neuregulin
signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron
26:443-455, 2000
Z.G. Luo, Q. Wang, J.Z. Zhou, J. Wang, Z. Luo, M. Liu, X. He, A. Wynshaw-Boris, W.C. Xiong, B. Lu, Lin Mei. Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1. Neuron 35:489-505, 2002.
B. Zhang, S.-W. Luo, X.-P. Dong, X. Zhang, C. Liu, Z. Luo, W.C. Xiong, L. Mei. b-Catenin regulates AChR clustering in muscle cells through interaction with rapsyn. J. Neurosci. 27:3968-3973, 2007
R.-S. Woo, X.M. Li, Y. Tao, E. Carpenter-Hyland, Y.Z. Huang, J. Weber, H. Neiswender, X.-P. Dong, J. Wu, M. Gassmann, C. Lai, W.-C. Xiong, T.-M. Gao, L. Mei. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54:599-610, 2007
Bo Li, R.S. Woo, Lin Mei, Roberto Malinow. The neuregulin1 receptor ErbB4 controls glutamatergic synapse maturation and plasticity. Neuron 54:583-597, 2007