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CURRICULUM VITAE

DARRELL W. BRANN, Ph.D.

Regents' Professor
Institute of Molecular Medicine & Genetics

Director, Graduate Program in Neuroscience
Medical College of Georgia


Personal Data:

Citizenship: U.S.
Military Service: U. S. Army
Office Phone #: (706)-721-7779
Fax #: (706)-721-8685
E-Mail: dbrann@mail.mcg.edu


Education:

Henderson State University: B.A. in Biology (Cum Laude) 1984.
Medical College of Georgia: Ph.D. (with Distinction) in Endocrinology, 1990.

Postdoctoral Training:

Postdoctoral Fellow (Neuroendocrinology) Department of Physiology and Endocrinology, Medical College of Georgia, April 1, 1990 - March 31, 1991.

Academic Appointments:

Assistant Research Scientist, Department of Physiology and Endocrinology, Medical College of Georgia, April 1, 1991 - March 31, 1992.

Assistant Professor, Department of Physiology and Endocrinology, Medical College of Georgia, April 1, 1992 – 30 June 1996.

Associate Professor, Department of Physiology, Medical College of Georgia, July 1, 1996 – June 30, 2001. Tenure granted 1 July 1998.

Associate Professor, Institute of Molecular Medicine and Genetics, and Department of Neurology, Neurobiology Program, Medical College of Georgia, July 1, 2001 – June 30, 2002.

Professor, Institute of Molecular Medicine and Genetics, and Department of Neurology,
Neurobiology Program, Medical College of Georgia, July 1, 2002 - present.

Associate Director and Professor, Institute of Neuroscience, Medical College of Georgia, January 1, 2005 – present.

Editorial Boards:

Neuroendocrinology (1994 - 1997; 1997 - 1999; 2006 - 2009)
Molecular Andrology (1993 - 1998)
American Journal of Physiology (1996 - 1997)
Biology of Reproduction (1997 - 1999)
Archives of Andrology (1997 - 1998)
Endocrinology (1997 - 2001)

Editorships:

Associate Editor, Biology of Reproduction (1999-2004)

Review Committees:

National

Member, Reproductive Endocrinology Study Section,
National Institutes of Health, 1998-2002.

Reviewer, National Science Foundation, Neuroendocrinology Section,
August, 1995, April 1996, March 1997.

Ad Hoc Member, Human Embryology and Development Study Section,
National Institutes of Health, February 16-18, 1994.

Ad Hoc Member, Reproductive Endocrinology Study Section,
National Institutes of Health, October 30-31, 1997.

Ad Hoc Member, NIH Program Project Site Visit Committee,
National Institutes of Health, March 29-31, 2000.

Ad Hoc Member, Special Study Section, NICHD
National Institutes of Health, March 19-20, 2002.

Ad Hoc Reviewer, Department of Veteran Affairs, May 2002.

Ad Hoc Member, MDCN 7 (Molecular, Developmental, and Cellular Neuroscience 7
Study Section, National Institutes of Health, June 26-27, 2002.

Ad Hoc Member, Special Study Section, Center Grants, NIDDK
National Institutes of Health, December 3-4, 2002.

Chair, Special Emphasis Review Panel, National Institutes of Health, June 2003
Ad Hoc Member, Reproductive Endocrinology (REN) Study Section,
National Institutes of Health, October 6-7, 2003.

Ad Hoc Member, Reproductive Endocrinology (REN) Study Section,
National Institutes of Health, February 11-13, 2004.

Member, F02A Neurosciences Fellowship Study Section,
National Institutes of Health, 2004-2005.

Ad Hoc Member, Integrative and Clinical Endocrinology and Reproduction (ICER) Study
Section, National Institutes of Health, October 7-8, 2004.

Ad Hoc Member, Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section, National Institutes of Health, October 6-7, 2005.

Alternate Chair, Special Review Study Section, NIA, National Institutes of Health, November 3-4, 2005.

Chair, Special Review Study Section, NICHD, National Institutes of Health, June 7, 2006.

Ad Hoc Member, Fellowship Review Study Section, NICHD, National Institutes of Health, July 7-8, 2006.

Institutional

Member, Biomedical Research Support Grant (BRSG) Committee, 1993-1996.

Chairman, Biomedical Research Support Grant Committee, 1994-1996.

Member, MCGRI Grant Review Committee, 1994-1996, 1997-2000, 2002-2005.

Member, Dean’s Student Research Fellowship Committee, 1994-1998.

Chair, Combined Institutional Grant Program, MCG (2005-2008)

Society Memberships:

American Society for Biochemistry and Molecular Biology
American Society for Cell Biology
American Society for Neurochemistry
Society for Neuroscience
Society for the Study of Reproduction
Council of Science Editors
American Medical Writers Association

Reviewer for the Following Scientific Journals:

Advances in Physiology Education
American Journal of Physiology
Brain Research
Journal of Biological Chemistry
Endocrinology
Journal of Andrology
Journal of Endocrinology
Journal of Neural Transmission
Journal of Neuroendocrinology
Journal of Neuroscience
Journal of Reproduction and Fertility
Life Sciences
Journal of Neurochemistry
Neuroendocrinology
Neuropharmacology
Neuroscience
Molecular and Cellular Neurosciences
Experimental Biology and Medicine
Biology of Reproduction

Grant Awards:

Extramural:
Grant Awards As Principal Investigator:

Current

  1. (1R01 NS050730-01A1) (24 May 2005 – 31 April 2010) Neuroprotective and Neurogenic Effects of E2 and SERMs. NINDS, National Institutes of Health, D.W. Brann (PI) ($1,653,440).

  2. (1T32NS45543-01 A2) (1 July 2005 – 31 June 2010) Neurodegenerative diseases and neural repair. NINDS, NIH. R.K .Yu (PI) (Dr. Brann and Dr. Yu are Co-Directors of the Training Grant), ($773,420).

  3. (R01HD28964-10) (1 April 2001 – 31 March 2007) Astrocyte-Neuron Interactions and GnRH. Neuronal Function. National Institutes of Health ($1,276,580).

  4. (IRP00105W006B)(1 August 2006 - 31 July 2007) Molecular Mechanisms of GnRH Neuron Migration. MCGRI Intramural Interdisciplinary Research Program Grant, D.W. Brann (Co-PI) ($80,000)

Past

  1. (R01AG17186-01) (1 April 2001 – 31 March 2005) Mechanisms of Reproductive Aging. National Institutes of Health ($1,022,000) (no cost extension for 2005-2006).

  2. (R29HD28964) (1 Apr 1992 – 30 Mar 1997) Excitatory Amino Acids: Role in GnRH, LH & FSH Secretion. National Institutes of Health ($350,000, Total costs).

  3. (R01HD28964) (1 Apr 1997 – 31 Mar 2001) Excitatory Amino Acids: Role in GnRH, LH & FSH Secretion. National Institutes of Health ($836,801, Total costs).

  4. (UNCF/Merck/11-15-04-3000) (1 Aug 1996 – 31 July 1998) Role and Significance of
    Excitatory Amino Acids.     The College Fund/UNCF/Merck Pharmaceuticals ($40,000).

  5. (R13HD35474) (29 June 1997 – 4 July 1997) Excitatory Amino Acids and Brain Function: Gordon Research Conference, National Institutes of Health ($18,000).

  6. (R13HDN38442-01) (27 June 1999 – 2 July 1999) Excitatory Amino Acids and
    Brain Function: Gordon Research Conference    , NIH ($14,000).

  7. (T32HD07253-16) (01 Sept 1982– 30 April 2000) Endocrine aspects of reproductive
    biology    . NICHD, NIH. (Note: PI for 1999-2000 upon previous PI’s retirement).

  8. 11-12-04-3000 (1 July 1999 – June 30, 2002) Biological testing of novel drugs. Accelerated Pharmaceuticals, Inc., ($30,000).

Extramural Grant Awards Pending:

  1. (1R01 NS053817-01) (12/1/05 – 11/30/10) Mechanisms of Estrogen-Induced Synaptic Plasticity. NIH, D.W. Brann (PI) ($1,771,710) 25% effort, submitted.

  2. (U54 grant) (4/1/06 – 3/31/11) Center of GnRH neuron migration in reproduction. Project title: Molecular mechanisms of mouse GnRH neuron migration. (Dr. Xiong and Dr. Brann – Co-PIs), 10% effort.

Previous Grant Awards As Co-Investigator:

  1. (RO1HD1668) Effect of progesterone on gonadotropin secretion. (1 Dec 1988
    - 30 Nov 1993) Dr. Virendra B. Mahesh (Principal Investigator) National
    Institutes of Health ($535,968); 10% effort.

  2. (T32HD07253-16)(01 Sept 1982 – 30 April 2000) Endocrine aspects of reproductive
    biology.     NICHD, NIH. V. Mahesh (PI), ($229,620), 10% effort, (Dr. Brann, PI
    1999-2000).

Previous Intramural Grant Awards:

  1. (MCGRI) (1 May 1991 – 1 May 1992) EAAs and GnRH secretion. Medical College of
    Georgia Research Institute ($8,900).

  2. (MCGRI) (15 March 1992 – 1 June 1993) Kinins and reproduction. Medical College of
    Georgia Research Institute ($10,000).

  3. (MCGRI) (1 Mar 1994 – 29 Feb 1995) EAAs and Reproductive Aging. Medical College of Georgia Research Institute ($10,000).

  4. (MCGRI) (1996-1997) NO and CO – role in LH secretion. Medical College of
    Georgia Research Institute (1 June 1996 – 30 May 1997) ($10,000).

Awards and Honors:

Academic/Professional Awards and Honors:

1980       Alumni Academic Scholarship, Henderson State University
1982       Basford Scientific Scholarship, Henderson State University
1984       Heart & Key Award for Scholarship in Biology, Henderson State University
1984       Graduated "Cum Laude", Henderson State University
1987       Excellence in Research Award, Medical College of Georgia
1988       Excellence in Research Award, Medical College of Georgia
1989       National Research Service Award (National Institutes of Health;1989-90)
1989       Sigma Xi Outstanding Research Paper Award, Sigma Xi Research Society
1990       Ph.D. "with Distinction", Medical College of Georgia
1993       Appointed to the Editorial Board of Molecular Andrology
1994       Appointed to the Editorial Board of Neuroendocrinology
1994       “Outstanding Young Faculty Award”, School of Medicine, Medical
              College of Georgia
1994       Ad Hoc Reviewer, NIH Human Embryology & Development Study Section
1994       Member, Awards Committee, Society for the Study of Reproduction (1994-96)
1996       Invited Symposium Speaker, Society for the Study of Reproduction
1996       Co-Chair, "Endocrine" session, 7th Int Conf Assisted Reproduction
1996       Chair, "Gonadotropins" session, 29th Mtg Society for the Study of Reproduction
1996       Appointed to the Editorial Board of the American Journal of Physiology
1996       Organizer and Co-Sponsor, First Gordon Research Conference on
              "Excitatory Amino Acids and Brain Function" (1997 Conference)
1997       Appointed to the Editorial Board of Endocrinology
1997       Appointed to the Editorial Board of Biology of Reproduction
1997       Invited Speaker, Gordon Research Conference on "Excitatory Amino Acids and
              Brain Function"
1997       “Distinguished Research Award” School of Graduate Studies, Medical College of
              Georgia
1997       Ad Hoc Reviewer, NIH Reproductive Endocrinology Study Section
1997       Member, Program Committee, Society for the Study of Reproduction
1997       Vice Chair, 1997 Gordon Research Conference on "Excitatory Amino Acids and
              Brain Function"
1998       Member, Reproductive Endocrinology Study Section, NIH (1998-2002)
1998       Member, Gordon Research Conferences Council (1998-2002)
1999       Chair, Symposium on “New Insights into the Control of the GnRH Neuron”, 81st
              Annual Meeting of the Endocrine Society
1999       Associate Editor, Biology of Reproduction (1999-2004)
1999       Chair, 1999 Gordon Research Conference on "Excitatory Amino Acids and
              Brain Function"
2000       Member, Medical College of Georgia Alumni Board, 2000-2002
2000       Chair, Symposium on “Molecular Neurobiology of the GnRH
              Neuron”, 2000 Experimental Biology Annual Meeting
2000       Invited Speaker, Symposium on “Molecular Neurobiology of the
              GnRH Neuron”, 2000 Experimental Biology Annual Meeting
2000       Appointed to Preclinical Advisory Board for Amgen
2000       Outstanding Faculty Award, School of Graduate Studies, Medical
              College of Georgia
2000       Invited Speaker, Symposium on “GnRH Regulation by
              Neurotransmitters and Puberty”, 2001 Endocrine Society Annual Meeting
2001       Chair, Symposium on “New Insights into Estrogen Action
              in the Brain”, 2001 Society for the Study for Reproduction Annual Meeting
2001       Invited Speaker, Symposium on “New Insights into Estrogen Action
              in the Brain”, 2001 Society for the Study for Reproduction Annual Mtg
2001       Distinguished Alumnus Award, School of Graduate Studies, Medical
              College of Georgia
2001       Invited Speaker, Symposium on “Neuroprotective Actions of
              Estrogen” 2002 Experimental Biology Annual Meeting
2002       Distinguished Faculty Award, Basic Science Research, School of Medicine,
              Medical College of Georgia
2003       Chair, NIH Special Emphasis Review Panel, National Institutes of Health
2003       Chair and Invited Speaker, Symposium on “Estrogen and Neurodegenerative
              Diseases: A Protective Role?” 2003 American Society for
              Neurochemistry 34th Annual Meeting
2004       Chair and Invited Speaker, Session on “Action of Steroids on
              Neuroprotection and Neuroendocrine Regulation” 2004 Experimental
              Biology Annual Meeting.
2004       Invited Speaker, 16th International Symposium of the Journal of Steroid
              Biochemistry & Molecular Biology.
2005       Appointed Associate Director, Institute of Neuroscience, Medical College of
              Georgia
2005       Outstanding Basic Science Teaching Award, School of Medicine, Medical College
              of Georgia
2006       Distinguished Alumni Award, Henderson State University, Arkansas
2006       Director, Graduate Program in Neuroscience, Medical College of Georgia
2007       Invited Chair, Symposium on Hormones and neuroplasticity 2007 Annual
              Endocrine Society Meeting
2007       Co-Chair, Brain Region II Study Section, American Heart Association
2007       Distinguished Teacher Award, School of Graduate Studies, Medical College of
              Georgia
2007       Regents Professor, Medical College of Georgia
2008       Guest Editor, Special Issue on New Insights into Estrogen Signaling and Actions
              in the Brain in Molecular and Cellular Endocrinology

Invited Scientific Presentations

  1. Department of Obstetrics and Gynecology, Medical College of Georgia,
    Augusta, GA (1991)

  2. 10th International Symposium of the Journal of Steroid Biochemistry and
    Molecular Biology, Paris, France; (1991)

  3.  5th World Congress of Biological Psychiatry, Florence, Italy; (1991)

  4. Department of Anatomy and Cell Biology, Emory University School of
    Medicine, Atlanta, GA (1993)

  5. Fourth International Conference for Assisted Reproductive Technology and
    Andrology, Alicante, Spain (1993)

  6. Fourth International Conference for Assisted Reproductive Technology and
    Andrology, Alicante, Spain (1993)

  7. Ninth International Congress on Hormonal Steroids, Dallas, TX (1994)

  8. Department of Cell Biology and Anatomy, Medical College of Georgia,
    Augusta, GA (1994).

  9. Department of Physiology, Eastern Virginia Medical School, Norfolk, VA, (1994).

  10.  Department of Medicine, Medical College of Georgia, Augusta, GA (1994).

  11. Fifth International Conference for Assisted Reproductive Technology and Andrology, Austria (1994)

  12. MCG Chapter of the Society for Neuroscience, Medical College of Georgia (1996)

  13. Department of Physiology, Southern Illinois University, Carbondale, IL (1996).

  14. Seventh International Conference for Assisted Reproductive Technology and
    Andrology, Zermatt, Switzerland (1996)

  15. 29th Meeting of the Society for the Study of Reproduction, London, Ontario, CA (1996).

  16. XVIII Meeting of the International Study Group on Steroid Hormones, Rome,
    Italy (1997)

  17. Center for Neurobiology, Mount Sinai School of Medicine, New York, NY, (1997)

  18. Gordon Research Conference on Excitatory Amino Acids and Brain Function (1997)

  19. Symposium on Reproductive Biology and Hormone Action (1998)

  20. Symposium on “Molecular Neurobiology of the GnRH Neuron”
    2000 Experimental Biology Annual Meeting.

  21. Department of Physiology, Medical College of Georgia (2000)

  22. Symposium on “GnRH Regulation by Neurotransmitters and Puberty” 2001
    Endocrine Society Annual Meeting.

  23. Symposium on: “New Insights into Estrogen Action in the Brain” 2001 Society
    for the Study of Reproduction Annual Meeting

  24. Seminar, Department of Physiological Sciences, East Virginia Medical School (2001)

  25. Seminar, Institute of Molecular Medicine and Genetics, Medical College of Georgia (2001)

  26. Seminar, National Institute for Environmental Health and Services (2001)

  27. Seminar, Department of Biochemistry and Molecular Biology, University of Georgia at Athens (2002)

  28. Symposium on “Neuroprotective Actions of Estrogens” 2002 Experimental Biology Meeting (2002)

  29. Seminar, Minority Biomedical Research Support Program, Morehouse School of Medicine (2002)

  30. Symposium, Estrogen and Neurodegenerative Diseases: A Protective Factor?, 2003 American Society for Neurochemistry (2003)

  31. Invited Speaker on “Action of Steroids on Neuroprotection and Neuroendocrine
    Regulation” 2004 Experimental Biology Annual Meeting (2004).

  32. Invited Speaker, 16th International Symposium of the Journal of Steroid Biochemistry & Molecular Biology (2004).

  33. Seminar, University of South Carolina School of Medicine, Department of Neuroscience (2004)

  34. Symposium, Neurobiology of Aging, Bregentz, Austria (Dhandapani K and Brann D) (2006)

  35. Speaker and Organizer, 1st Georgia/South Carolina Neuroscience Consortium Meeting, Charleston, South Carolina (2006)

  36. Invited Speaker, Session on Hypothalamic-Pituitary-Gonadal Regulation III, Society for Neuroscience Annual Meeting (2006)

Institutional Service

Committees and Other Service:

  • Faculty Senate Representative (1991-1997)

  • FACTS Program (Departmental Coordinator) (1992-1997)

  • Faculty Seminar Coordinator (1991-1993)

  • LCME Subcommittee for Basic Science Departments (1992-1994)

  • Biomedical Research Support Grant Committee (1993-1996)

  • Chairman, Biomedical Research Support Grant Committee (1994-1996)

  • MCGRI Grants Review Committee (1995-1997, 1998-2001)

  • Dean's Medical Student Research Committee (1995-1997)

  • Graduate Faculty Affairs Committee (1994-1996)

  • Member, Search Committee, Dept. of Pharmacology & Toxicology (1996-1997)

  • Member, Search Committee, Dept. of Physiology & Endocrinology (1997-1998)

  • Associate Director, Endocrine Clinical Lab, MCG (1992-1999)

  • Dean’s Task Force on Compensation (1995-1997)

  • President-Elect, MCG Chapter of the Society for Neuroscience (1995)

  • President, MCG Chapter of the Society for Neuroscience (1996-1998)

  • Co-Chair, Dean’s Neuroscience Working Group, School of Medicine (1996-1997)

  • Member, MCG Educational Policy Committee (1997-2000)

  • Chair, Search Committee, Dept. of Physiology & Endocrinology (1997-1998)

  • Member, Search Committee, MCG (Director, Grants & Contracts) (1998)

  • Member, Search Committee, Department of Physiology (2000-2001)

  • Member, Medical College of Georgia Alumni Board (2000-2002)

  • Chair, Faculty Search Committee, IMMAG (2002)

  • Chair, Faculty Search Committee, IMMAG (2003)

  • Member, IMMAG ad hoc Promotion and Tenure Committee (2003-2006)

  • Member, MCG Faculty Academic Council (2003-2005)

  • Member, University Assessment Subcommittee (2003-2005)

  • Member, M.D./Ph.D. Advisory Committee (2003-2005)

  • Member, Combined Institutional Grant Program Review Committee, MCG (2003-2007)

  • Member, Biomedical Sciences PhD Program Curriculum Advancement Committee (2004-2007)

  • Member, Molecular Medicine Graduate Education Committee (2004-2005)

  • Member, Institute of Neuroscience Steering Committee (2005-2008)

  • Chair, Faculty Search Committee, IMMAG/Dev Neurobiol Program (2004-2005)

  • Course Director, Neuroscience I (SGS8080) (2005-2008)

  • Course Director, Neuroscience II (NSC8082) (2005-2008)

  • Chair, MCG Combined Institutional Grants Program (2005-2008)

  • Associate Director, Institute of Neuroscience (2005-2008)

  • Chair, Eminent Scholar Search Committee (2006-2007)


Institutional Support/Service – Other

  • Established an endowed Darrell W. Brann Scholarship Award in Neuroscience, Medical College of Georgia – (a 10 year endowed scholarship providing a $1,000 scholarship award per year to an outstanding neuroscience student in the School of Graduate Studies at the Medical College of Georgia).

Teaching Activities

Teaching:

ITD590: Reproduction – 2-4 hours of Lectures (Neuroendocrinology) (1994-1996)
END 821: Neuroendocrinology, (27 hours of lectures; 1993 - 2000).
END 707: Principles of Biological Regulation - 2 hours of lectures (1994-1996)
PHYS 200: Physiology (SEEP program) – taught the Endocrine block (1999-2000)
SGS 8030/8033: Functional Systems Biology/Integrative Systems Biology - Endocrine
Unit Director (I taught all 14 hours of lectures, 1997 – 2001, 2-6 h from 2002-present).
PHYS 3110/6011: Physiology – Taught 27 hours of lecture (entire Reproduction/Endocrine Block, and Blood and Immune System, and Neuroscience blocks, teaching: 1996 – 2001)
SGS 8010: Research Ethics, Scientific Communication and Teaching Skills – I taught the “teaching skills” part of the course (6 hours of lecture) (2001)
SGS8080: Neuroscience I, (4 credit hr course), 2h lecture, 2005-present
NURO 8082: Neuroscience II, (4 credit hour course) 8h lecture, 2005-present.

 Course Director:

END 821: Neuroendocrinology - (3 credit hr course) Course Director - 1993 - 2000.
PHYS 3110/6011: Physiology – (4 credit hr course) Course Director – 2001.
SGS8080: Neuroscience I - (4 credit hr course), Course Director - 2005-present.
NURO 8082: Neuroscience II - (4 credit hour course) Course Director - 2005-present.

WebCT and Advanced Technology in Teaching

  • Created a WebCT parallel course site for SGS8080 (first basic science graduate core course to incorporate a WebCT site into its course)

  • Created a WebCT parallel course site for NSC8082

  • First Graduate School course to utilize the Computer Performance System (CPS) to enhance classroom interaction and participation. (used in SGS8080 and NSC8082, which Dr. Brann directs)

Major Advisor:

Charisee Lamar (Ph.D. granted June 1998)
Current Position: Program Director for Health Disparities
and Women’s Health Research, NIH, NIAMS

Beien Shi (Ph.D. granted June 1998)
Current Position: MD, private practice
Clint Buchanan (Ph.D. “With Distinction” granted May 2000)
Current Position: Scientist, DNA Crime Laboratory, Georgia
Bureau of Investigation

Krishnan Dhandapani (Ph.D. “With Distinction”
granted March 2003)
Current Position: Assistant Professor,
Department of Neurosurgery, Medical College of Georgia

Advisory Committees:
(all Ph.D. candidates)

Richard Unda                      Pedro Zamorano
Philip George                      Gloria Mora
Vivanan Zamorano               Lu Zhang
Tongyun Lu                         Yu Liu
Juan Zhai                            Andy Clark
Bindiya Moorjani                  Erich Ottem
Ning Xu                               Mark Witcher

 Research Fellows:

Dr. Lin Ping                         Dr. Ganapathy Bhat
Dr. Pedro Zamorano             Dr. Martin Hadman (Asst Res Sci)
Dr. Viviana Zamorano           Dr. Krishnan Dhandapani
Dr. Kripamoy Aguan
Dr. Mohammed Khan (Asst Res Sci)
Dr. Mohan Wakade (Asst Res Sci)

Research Associate (current lab):

Liesl De Sevilla (Lab Manager)

Workshops and Symposia Attended for Career Development

  • Molecular Biology Workshop

  • Molecular and Cellular Advances in Endocrinology

  • Summer Institute in Research on Aging

  • The Centennial of the Neuron

  • Molecular Basis of Reproductive Endocrinology

  • Teaching Skills for Health Professions Educators

  • Novel Approaches for the Detection and Analysis of Functional Protein-Protein and Protein-DNA Interactions

Books

  1. "Excitatory Amino Acids: Their Role in Neuroendocrine Function" (CRC Book)
    Editors: D.W. Brann and V. B. Mahesh, CRC Press, Inc., Boca Raton, Fl. (1996).

Publications

Articles, Reviews and Book Chapters:

  1. Brann, D.W., Rao, I.M., Mahesh, V.B. (1988) Antagonism of estrogen-induced
    prolactin release by progesterone. Biology of Reproduction 39:1067-1073.

  2. Brann, D.W., Putnam, C.D., Mahesh, V.B. (1989) Antagonism of
    estrogen-induced prolactin release by dihydrotestosterone. Biology of
    Reproduction     40:1201-1207.

  3. Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Corticosteroid regulation
    of gonadotropin and prolactin secretion in the rat. Endocrinology 126:159-166.

  4. Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Corticosteroid regulation
    of gonadotropin secretion and induction of ovulation in the rat. Proceedings
    of the Society for Experimental Biology and Medicine     193:176-180.

  5. Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) GABAA receptors
    mediate 3a-Hydroxy-5a-pregnan-20-one induced gonadotropin secretion.
    Endocrinology 126:1854-1859.

  6. Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Dose-Related effects of
    progesterone and dihydroprogesterone upon estrogen-induced prolactin
    release. Journal of Neuroendocrinology 2:341-345.

  7. Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Similarities and
    differences in progesterone and androgens in modulation of LH, FSH and
    PRL release: Unexpected properties of flutamide. Journal of Steroid
    Biochemistry     36:287-294.

  8. Brann, D.W. and Mahesh, V.B. (1991) Endogenous excitatory amino acid
    regulation of the progesterone-induced LH and FSH surge in estrogen-primed
    ovariectomized rats. Neuroendocrinology 53:107-110 (Rapid Communication).

  9. Brann, D.W., Putnam, C.D., Mahesh, V.B. (1991) Validation of the mechanisms
    proposed for the stimulatory and inhibitory effects of progesterone on gonadotropin
    secretion in the estrogen-primed rat. A possible role for adrenal steroids. Steroids
    56:103-111.

  10. Brann, D.W. and Mahesh, V.B. (1991) Endogenous excitatory amino acid
    involvement in the preovulatory and steroid-induced surge of gonadotropins
    in the female rat. Endocrinology 128:1541-1547.

  11. Brann, D.W. and Mahesh, V.B. (1991) Detailed examination of the mechanism
    and site of action of progesterone and corticosteroids in the regulation of
    gonadotropin secretion: Hypothalamic Gonadotropin-Releasing Hormone and
    catecholamine involvement. Biology of Reproduction 44:1005-1015.

  12. Brann, D.W., McDonald J.K., Putnam, C.D., Mahesh, V.B. (1991) Regulation of
    hypothalamic Gonadotropin-Releasing Hormone and Neuropeptide Y concentrations by progesterone and corticosteroids in immature rats: Correlation with Luteinizing Hormone and Follicle Stimulating Hormone Release. Neuroendocrinology 54:425-432.

  13. Putnam, C.D., Brann, D.W., Mahesh, V.B. (1991) Acute activation of the ACTH-adrenal axis: Effect upon gonadotropin secretion in the female rat. Endocrinology 128:2558-2566.

  14. Putnam, C.D., Brann, D.W., Kolbeck, R.C., Mahesh, V.B. (1991) Inhibition of uterine contractility by progesterone and progesterone metabolites: Mediation by progesterone and gamma amino butyric acidA receptor systems. Biology of Reproduction 45:266-272.

  15. Brann, D.W. and Mahesh, V.B. (1991) Regulation of gonadotropin secretion by steroid hormones. Frontiers in Neuroendocrinology 12:165-207.

  16. Mahesh, V.B. and Brann, D.W. (1992) Interaction between ovarian and adrenal
    steroids in the regulation of gonadotropin secretion. Journal of Steroid Biochemistry and Molecular Biology 41:495-513.

  17. Mahesh, V.B., Brann, D.W., Putnam, C.D. (1991) Modulation of GABAergic
    neurotransmission by progestins. Biological Psychiatry 2:518-521.

  18. Brann, D.W., Putnam, C.D. and Mahesh, V.B. (1991) Regulation of Follicle-
    Stimulating Hormone by natural and synthetic corticosteroids. In: Regulation and
    Action of Follicle Stimulating Hormone, Serono Press, pp 303-309.

  19. Brann, D.W. and Mahesh, V.B. (1991) Role of corticosteroids in female reproduction. The FASEB Journal 5:2691-2698 (Invited MiniReview).

  20. Brann, D.W. and Mahesh, V.B. (1992) Excitatory amino acid regulation of
    gonadotropin secretion: Modulation by steroid hormones. Journal of Steroid Biochemistry and Molecular Biology 41:847-850.

  21. Brann, D.W. and Mahesh, V.B. (1992) Excitatory amino acid neurotransmission:
    Evidence for a role in neuroendocrine regulation. Trends in Endocrinology & Metabolism 3:120-124.

  22. Putnam, C.D., Brann, D.W., Mahesh, V.B. (1992) Role of 5a-reduction in progesterone's ability to release LH and FSH in ovariectomized rats. Journal of Steroid Biochemistry and Molecular Biology 42:875-882.

  23. Brann, D.W., Zamorano P., Putnam-Roberts C. and Mahesh, V.B. (1992) GABA-Opioid interactions in the regulation of gonadotropin secretion in the female
    rat. Neuroendocrinology 56:445-452.

  24. Brann, D.W., O'Conner, J.C., Wade, M. and Mahesh, V.B. (1992) LH and FSH subunit mRNA concentrations during the progesterone induced gonadotropin surge in ovariectomized estrogen-primed immature rats. Molecular and Cellular Neurosciences 3:171-178.

  25. Brann, D.W., Putnam, C.D. and Mahesh, V.B. (1992) Progesterone and corticosteroid regulation of hypothalamic and pituitary opioid content during LH surge induction. Molecular and Cellular Neurosciences 3:191-198.

  26. Gao, X., Greenbaum L.M., Mahesh, V.B. and Brann, D.W. (1992)
    Characterization of the kinin system in the ovary during ovulation in the rat. Biology of Reproduction 47:945-951.

  27. Brann, D.W. (1993) Progesterone: The Forgotten Hormone. Perspectives in Biology and Medicine 36:642-653.

  28. Brann, D.W., Zamorano, P.L., Ping L. and Mahesh, V.B. (1993) Role of excitatory amino acid neurotransmission during puberty in the female rat. Molecular and Cellular Neurosciences 4:107-112.

  29. Brann, D.W., Ping L. and Mahesh, V.B. (1993) Role of non-NMDA receptor
    neurotransmission in steroid and preovulatory gonadotropin surge expression in the female rat. Molecular and Cellular Neurosciences 4:292-297.

  30. Brann, D.W., Zamorano, P.L., Chorich L. and Mahesh, V.B. (1993) Steroid
    hormone effects upon NMDA receptor binding and mRNA levels in the hypothalamus
    and cerebral cortex of the adult rat. Neuroendocrinology 58: 666-672.

  31. Brann, D.W., and Mahesh V. B. (1993) Role of excitatory amino acids in reproduction. Advances in Contraceptive Delivery Systems 9:176-177.

  32. Gao, X., Greenbaum L.M., Mahesh, V.B. and Brann, D.W. (1993) Role of the kinin
    system in reproduction. Assisted Reproductive Technology/Andrology 5:197-200.

  33. Mahesh, V.B. and Brann, D.W. (1993) Relationship between anterior pituitary estrogen receptor dynamics and the preovulatory gonadotropin surge. Advances in Contraceptive Delivery Systems 9:221-222.

  34. O'Conner J., Wade M., Brann D.W., and Mahesh V.B. (1993) Direct anterior pituitary modulation of gonadotropin secretion by neuropeptide Y (NPY); Role of gonadal steroids. Neuroendocrinology 58:129-135.

  35. Brann, D.W., and Mahesh V. B. (1993) Neuroendocrine regulation of gonadotropin
    secretion: Role of excitatory amino acids. Assisted Reproductive Technology/Andrology 5:201-212.

  36. Mahesh V.B. and Brann, D.W., (1993) Modulation of the preovulatory gonadotropin
    surge by progesterone induced changes in anterior pituitary estrogen receptors. Assisted Reproductive Technology/Andrology 5:1-14.

  37. Gao XX, Greenbaum L.M., Mahesh V.B. and Brann D.W. (1993) The kinin system and ovulation. Advances in Contraceptive Delivery Systems 9:223-230.

  38. Brann, D.W., O'Conner, J.C., Wade, M. and Mahesh, V.B. (1993) Regulation of anterior pituitary gonadotropin subunit mRNA levels during the preovulatory gonadotropin surge:A physiological role of progesterone in regulating LH-b and FSH-b mRNA levels. Journal of Steroid Biochemistry and Molecular Biology 46:427-437.

  39. Brann, D.W., Chorich L. P., Zamorano P.L.. and Mahesh, V.B. (1993) Presence of
    NMDA receptor mRNA in the anterior pituitary of the female rat: Steroid modulation and changes during the preovulatory gonadotropin surge. Molecular and Cellular Neurosciences 4:571-575.

  40. Brann, D.W., Chorich L. P. and Mahesh, V.B. (1993) Effect of progesterone on
    galanin mRNA levels in the hypothalamus and pituitary: Correlation with the
    gonadotropin surge. Neuroendocrinology 58:129-135.

  41. Mahesh V.B. and Brann D.W. (1994) Role of estrogens and progesterone in inducing preovulatory type LH and FSH secretion. Assisted Reproductive Technology/Andrology 6:18-20.

  42. Brann D.W. and Mahesh V.B. (1994) Role of NMDA/Non-NMDA
    neurotransmission in induction of puberty and pulsatile LH secretion. Assisted
    Reproductive Technology/Andrology     6:12-14.

  43. Brann, D.W., and Mahesh, V.B. (1994) Excitatory amino acids: Function and significance in reproduction and neuroendocrine regulation. Frontiers in Neuroendocrinology (Invited Review), 15:3-49.

  44. Ping L., Mahesh V.B. and Brann D.W. (1994) Release of glutamate and aspartate from the preoptic area during the progesterone-induced LH surge: In vivo microdialysis studies. Neuroendocrinology 59:318-324.

  45. Ping L., Mahesh V.B. and Brann D.W. (1994) A physiological role for NMDA and
    non-NMDA receptors in pulsatile gonadotropin secretion in the adult female rat.
    Endocrinology 135:113-118.

  46. Brann D.W. and Mahesh V.B. (1995) LH Secretion: Control by excitatory amino acids. Assisted Reproductive Technology/Andrology 7:1-8.

  47. Brann, D.W. (1995) Glutamate - A major excitatory transmitter in neuroendocrine
    regulation. Neuroendocrinology 61:213-225. (Invited MiniReview)

  48. Brann, D.W., Hendry L. B. and Mahesh, V.B. (1995) Steroid hormones: Emerging
    concepts of diversities in the mechanism of action. Journal of Steroid Biochemistry and Molecular Biology 52:113-133. (Invited Review)

  49. Mahesh V.B. and Brann D.W. (1995) Steroidal regulation of gonadotropin
    secretion: Role of ovarian progesterone and adrenal steroids. Assisted Reproductive
    Technology/Andrology     7:15-25.

  50. Brann D.W. and Mahesh, V.B. (1995) Glutamate: A major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion. Journal of Steroid Biochemistry and Molecular Biology 53:325-329.

  51. Brann, D.W., Greenbaum L., Mahesh V.B. and Gao X.X. (1995) Changes in kininogens and kallikrein in the plasma, brain and uterus during pregnancy in the rat. Endocrinology 136:46-51.

  52. Ping L., Mahesh V.B. and Brann D.W. (1995) Effect of NMDA and Non-NMDA
    receptor antagonists on pulsatile luteinizing hormone secretion in the adult male rat.
    Neuroendocrinology 61:226-234.

  53. O’Conner J., Wade M., Brann D.W., and Mahesh V.B. (1995) Evidence that
    progesterone modulates anterior pituitary neuropeptide Y levels during the
    progesterone-induced gonadotropin surge in the estrogen-primed intact immature female rat. Journal of Steroid Biochemistry and Molecular Biology 52: 497-504.

  54. Bhat G., Mahesh V.B., Lamar C.A., Ping L., Aguan K. and Brann D.W. (1995)
    Histochemical localization of nitric oxide neurons in the hypothalamus:
    Association with gonadotropin-releasing hormone (GnRH) neurons and co-localization with N-methyl-D-aspartate (NMDA) receptors. Neuroendocrinology 62:187-197.

  55. Unda R., Brann D.W. and Mahesh V.B. (1995) Progesterone suppression
    of glutamic acid decarboxylase (GAD67) mRNA levels in the preoptic area:
    Correlation to the luteinizing hormone surge. Neuroendocrinology 62:562-570.

  56. Bhat G., Mahesh V.B., Chu Z.W., Chorich L.P., Zamorano P.L. and Brann D.W. (1995) Localization of the N-methyl-D-aspartate (NMDA) R1 receptor subunit in specific anterior pituitary hormone cell types of the female rat. Neuroendocrinology 62:178-186.

  57. Brann, D.W., Mills T. and Mahesh, V.B. (1995) Female Reproduction: The
    Ovulatory Cycle. In: Reproductive Toxicology, Raven Press, New York, Ed.: R. Witorsch, Chapter 2, pp. 23-44.

  58. Brann, D.W., L. Ping, P. Zamorano and Mahesh, V.B. (1996) Role of excitatory
    amino acids in reproduction. In: "Excitatory Amino Acids: Their Role in
    Neuroendocrine Function" Editors: D.W. Brann and V. B. Mahesh, CRC Press, Inc., Boca Raton, Fl., Chapter 4,     pp. 133-166.

  59. Mahesh, V.B. and Brann, D.W. (1996) Steroid control of hypothalamic function. In:
    "CNS Neurotransmitters and Neuromodulators", Editor: T.W. Stone, CRC Press Inc., Boca Raton, Fl., Chapter 10    , pp. 177-210.

  60. Rapkin A.J., Shoupe D., Reading A., Bohn Y., Brann D.W., and Mahesh V.B. (1996) Decreased central opioid activity in premenstrual syndrome: Luteinizing hormone response to naloxone. J Soc Gynecol Invest 3:93-98.

  61. Mahesh V.B., Brann D.W. and Hendry L.B. (1996) Diverse modes of action of
    progesterone and its metabolites. Journal of Steroid Biochemistry and Molecular Biology 56:209-219.

  62. Lamar C.A., Mahesh V.B. and Brann D.W. (1996) Regulation of gonadotropinreleasing hormone (GnRH) secretion by heme molecules: A regulatory role for carbon monoxide? Endocrinology 137:790-793

  63. Zamorano P.L., Mahesh V.B. and Brann D.W. (1996) Quantitative RT-PCR
    for neuroendocrine studies - a minireview. Neuroendocrinology 63:397-407.

  64. Trott E.A., Plouffe L., Hansen K., Tho S., Hines R., Brann D.W., Mahesh V.B. (1996) Ovulation induction in clomiphene-resistant anovulatory women with normal
    dehydroepiandrosterone sulfate levels: Beneficial effects of the addition of dexamethasone during the follicular phase. Fertility & Sterility 66:484-486.

  65. Zuo Z., Mahesh V.B., Zamorano P.L. and Brann D.W. (1996) Decreased GnRH
    neurosecretory response to glutamate agonists in middle-aged female rats on
    proestrus afternoon: A possible role in reproductive aging. Endocrinology 137:2334-2338.

  66. Bhat G., Mahesh V.B., Aguan K. and Brann D.W. (1996) Evidence that
    brain-nitric oxide synthase (b-NOS) is the major NOS isoform in the
    hypothalamus of the adult female rat and that nitric oxide potently regulates
    hypothalamic cGMP levels. Neuroendocrinology 64:93-102.

  67. Aguan K., Mahesh V.B., Ping L., Bhat G. and Brann D.W. (1996) Evidence for
    a physiological role for nitric oxide in the regulation of the LH surge: Effect of
    central administration of antisense oligonucleotides to nitric oxide synthase.
    Neuroendocrinology 64:449-455.

  68. Zamorano P, Mahesh V, De Sevilla L, Chorich L, Bhat G, Brann D.W. (1997)
    Expression and localization of the leptin receptor in endocrine and
    neuroendocrine tissues of the rat. Neuroendocrinology 65:223-228

  69. Brann D.W. (1997) The neuroimmunoendocrinology of gaseous modulators.
    Current Opinion in Endocrinology and Diabetes 4:138-144.

  70. Brann D.W., Bhat G.K., Lamar C.A. and Mahesh V.B. (1997) Gaseous
    transmitters and neuroendocrine regulation. Neuroendocrinology 65:385-395.

  71. Brann D.W. and Mahesh, V.B. (1997) Excitatory Amino Acids: Evidence for a
    role in the control of reproduction and anterior pituitary hormone secretion.
    Endocrine Reviews 18:678-700.

  72. Zamorano P.L., De Sevilla L., Mahesh V.B. and Brann D.W. (1997) Production
    and refolding of recombinant leptin. BioTechniques 23:800-803.

  73. Ping L., Mahesh V.B., Bhat G.K. and Brann D.W. (1997) Regulation of GnRH
    and LH secretion by AMPA receptors. Evidence for a physiological role of
    AMPA receptors in production of the LH surge. Neuroendocrinology 66:246-253.

  74. Rapkin AJ, Morgan M, Goldman L, Brann D.W., Simone D, Mahesh V.B. (1997)
    Progesterone metabolite allopregnanolone in women with premenstrual
    syndrome. Obstetrics and Gynecology 90:709-714.

  75. Mahesh VB, Brann DW (1998) Neuroendocrine mechanisms underlying the
    control of gonadotropin secretion by steroid hormones. Steroids 63:252-256.

  76. Zamorano P.L., Mahesh V.B., De Sevilla L. and Brann D.W. (1998) Excitatory
    amino acid receptors and puberty. Steroids 63:268-270.

  77. Shi B., Mahesh V.B., Bhat G.K., Ping L. and Brann D.W. (1998) Evidence for a
    role of bradykinin neurons in the control of luteinizing hormone-releasing
    hormone secretion. Neuroendocrinology 67:209-218.

  78. Bhat G.K., Mahesh V.B., Ping L. and Brann D.W. (1998) Opioid-glutamatenitric
    oxide connection in the regulation of luteinizing hormone secretion in the
    rat. Endocrinology 139: 955-960.

  79. Buchanan CL, Mahesh VB, Zamorano PL, Brann D.W. (1998) CNS Effects of Leptin.Trends Endocrinol Metab 9:146-150.

  80. Mahesh VB and Brann D.W. (1998) Regulation of the Preovulatory Gonadotropin Surge by Endogenous Steroids. Steroids 63:616-629.

  81. Brann D.W., De Sevilla L, Zamorano P, Mahesh VB (1999) Regulation of leptin
    gene expression and secretion by steroid hormones. Steroids 64:659-663.

  82. Mahesh V.B., Zamorano P.L., De Sevilla L, Lewis D, Brann D.W. (1999)
    Characterization of ionotropic glutamate receptors in rat hypothalamus,
    pituitary and in immortalized GnRH neurons (GT1-7 Cells). Neuroendocrinology 69:397-407.

  83. Shi B., Bhat G., Brotto M., Mahesh V.B., Nosek T., Brann D.W. (1999)
    Bradykinin receptor localization and cell signaling pathways utilized by
    bradykinin in the regulation of GnRH secretion. Endocrinology 140:4669-4676.

  84. Lamar C., Bhat G., Mahesh V., Brann D.W. (1999) Evidence that neuronal
    nitric oxide synthase but not heme oxygenase increases in the hypothalamus on
    proestrous afternoon. Neuroendocrinology 70:360-367.

  85. Cannady W.E., Brann D.W., Mahesh V.B. (2000) The potential role of
    periovarian fat and leptin in initiation of puberty in the immature rat. Int J
    Obesity     24:S146-S147.

  86. Buchanan C., Mahesh V.B., Brann D.W. (2000) Estrogen-Astrocyte-LHRH
    signaling: A role for transforming growth factor-b1. Biology of Reproduction
    62:1710-1721.

  87. Dhandapani K., Brann D.W. (2000) The role of glutamate and nitric oxide in
    the reproductive neuroendocrine system. Biochemistry and Cell Biology 78:165-179.

  88. Bilger M., Heger S., Brann D.W., Ojeda S. (2001) A conditional tetracyclineregulated increase in GABA production near LHRH nerve terminals disrupts estrous cyclicity in the rat. Endocrinology 142:2102-2114.

  89. Mahesh V., Roach L., Cannady W., Ogle T., Brann D.W., Bransome E., Hendry L. (2001) Gene based pharmacophores for drug design. Med Chem Res, 10:440-455.

  90. Brann D.W., Wade M, Dhandapani K, Mahesh V, Buchanan C (2002) Leptin
    and Reproduction. Steroids 67:95-104.

  91. Dhandapani KM, Wade MF, Mahesh VB and Brann D.W. (2002) Basic fibroblast growth factor induces TGF-b release in an isoform and glioma-specific manner. NeuroReport 13:239-241.

  92. Dhandapani K. and Brann D.W. (2002) Protective effects of estrogens and SERMs in the brain. Biology of Reproduction 67:1379-1385.

  93. Brann D.W., Greenbaum LM, Mahesh VB, Gao XX (2002) Activation of the
    kinin system in the ovary during ovulation: role of endogenous progesterone.
    BMC Physiology, issue 2: article #7

  94. Dhandapani K. and Brann D.W. (2002) Orphanin FQ inhibits GnRH secretion
    from rat hypothalamic fragments but not GT1-7 neurons. NeuroReport 13:1247-1249.

  95. Dhandapani K.M., Brann D.W. (2002) Estrogen-astrocyte interactions: Implications for neuroprotection. BMC Neuroscience, issue 3, article #6

  96. Brann D.W., Unda R., Mahesh V.B. (2002) A role for the progesterone receptor in
    restraining glutamic acid decarboxylase gene expression in the hypothalamus during the preovulatory LH surge. Neuroendocrinology 76:283-289.

  97. Dhandapani K., Mahesh V.B. and Brann D.W. (2003) Astrocytes and brain function:
    implications for reproduction. Exp Biol Med 228:253-260.

  98. Mehta S.H., Dhandapani K.M., DeSevilla L.M., Webb R.C., Mahesh V.B., Brann D.W. (2003) Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat.
    Neuroendocrinology 77:44-50.

  99. Dhandapani K.M. and Brann D.W. (2003) Transforming growth factor-b: a neuroprotective factor in cerebral ischemia. Cell Biochemistry and Biophysics 39:13-22.

  100. Dhandapani K.M. and Brann D.W. (2003) Neuroprotective effects of estrogen and
    tamoxifen in vitro: A facilitative role for glia? Endocrine 21:59-66

  101. Gu, X., Zhang J., Brann D.W., Yu F.S. (2003) Brain and retinal vascular endothelial cells with extended lifespan established by ectopic expression of telomerase. Invest Opthal Visual Sci 44:3219-3225.

  102. Dhandapani K., DeSevilla L., Mahesh VB and Brann D.W. (2003) Astrocyte protection of neurons: Role of TGF-b signaling via a cJun-AP1 protective pathway.
    Journal of Biological Chemistry 278:43329-43339.

  103. Brann D.W., Mahesh VB (2005) The aging reproductive neuroendocrine axis.
    Steroids 70:273-283.

  104. Brann D.W., Zamorano PL, De Sevilla L, Mahesh VB (2005) Expression of glutamate receptor subunits in the hypothalamus of the female rat during the afternoon of the proestrous LH surge and effects of antiprogestin treatment and aging. Neuroendocrinology 81:120-128

  105. Wade FM, Wakade C, Mahesh VB, Brann D.W. (2005) Differential expression of the
    peripheral benzodiazepine receptor and gremlin during adipogenesis as identified by
    differential display analysis. Obesity Research 13:818-822.

  106. Dhandapani KM, Wade FM, Mahesh VB, Brann D.W. (2005) Astrocyte-derived transforming growth factor-b mediates the neuroprotective effects of 17b-estradiol: involvement of nonclassical genomic signaling pathways. Endocrinology 146:2749-2759.

  107. Dhandapani KM, Wade FM, Mahesh VB, Brann D.W. (2005) Neuroprotection by stem cell factor in rat cortical neurons involves Akt and NFkB. J Neurochem, in press.

  108. Dhandapani KM, Wade FM, Mahesh VB, Brann D.W. (2005) Astrocyte-derived transforming growth factor-ß mediates the neuroprotective effects of 17ß-estradiol: involvement of non-classical genomic signaling pathways. Endocrinology 146:2749-2759.

  109. Khan, MM, Hadman M, Wakade C, De Sevilla LM, Dhandapani KM, Mahesh VB, Vadlamudi RK, Brann D.W. (2005) Cloning of rat MNAR/PELP1: Localizaiton in rat brain and colocalizaiton in estrogen receptor-α but not GnRH-positive neurons. Endocrinology 146:5215-5227.

  110. Mahesh VB, Dhandapani KM, Brann D.W. (2006) Role of astrocytes in reproduction and neuroprotection. Mol Cell Endocrinol 246:1-9.

  111. Brann D.W. , Sloop S. (2006) Curriculum development and technology incorporation in teaching neuroscience to graduate students in a medical school environment. Advan Physiol Edu 30:38-45.

  112. Dhandapani KM, Brann DW (2006) Role of astrocytes in estrogen-medicated neuroprotection. Exp Gerontology, in press.

  113. Dhandapani KM, Khan MM, Wade FM, Wakade C, Mahesh VB, Brann DW (2007) Induction of transforming growth factor-beta1 by basic fibroblast growth factor in glioma and astrocytes is mediated by MEK/ERK signaling and AP-1 activation. J Neurosci Res 85:1033-1045.

  114. Dhandapani KM, Mahesh VB, Brann DW (2007) Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkB transcription factors. J. Neurochem 102:522-538.

  115. Brann DW, Dhandapani K, Mahesh VB, Wakade C, Khan MM (2007) Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications. Steroids 72:381-405.

  116. Raz L, Khan, M, Mahesh VB, Vadlamudi RK, Brann DW. (2008) Rapid estrogen signaling in the brain. Neurosignals Vol. 16, No. 2-3, pp 140 - 153.

  117. Wakade M, Khan MM, De Sevilla L, Zhang QG, Mahesh VB, Brann DW. (2008) Tamoxifen Neuroprotection in Cerebral Ischemia Involves Attenuation of Kinase Activation and Superoxide Production and Potentiation of Mitochondrial Superoxide Dismutase. Endocrinology 149(1):367-79.

  118. Rajhans R, Nair HB, Nair SS, Cortez V, Ikuko K, Kirma NB, Zhou D, Holden A, Brann DW, Chen S, Tekmal RR, and Vadlamudi RK. (2008) Modulation of in situ estrogen synthesis by PELP1: Potential ERautocrine signaling loop in breast cancer cells. Mol Endocrinol. 22(3):649-64.

  119. Nagpal JK, Nair S, Chakravorty D, Rajhans R, Pothana S, Brann DW, Tekmal RR, Vadlamudi RK. (2008) Growth factor regulation of ER-coregulator PELP1 functions via PKA pathway. Molecular Cancer Research 6(5):851-861.

  120. Brann DW, Mahesh VB, Zhang QG, Vadlamudi RK. (2008) PELP1 a novel estrogen-receptor-interacting protein in the brain. Mol Cell Endocrinology, in press.

Abstracts

Brann, D.W. and Mahesh, V.B. (1991) Endogenous excitatory amino acid involvement in the preovulatory and steroid-induced surge of gonadotropins in the female rat. 10th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology, Abstract # 81P.

Mahesh, V.B., Brann, D.W. and Putnam, C.D. (1991) Modulation of GABAergic
Neurotransmission by Progestins. 5th World Congress of Biological Psychiatry, page 518.

Brann, D.W., Zamorano, P., and Mahesh, V.B. (1992) Possible physiological role for NMDA receptors in the neuroendocrine mechanism regulating preovulatory gonadotropin secretion. Excitatory Amino Acids 1992, FIDIA Symposia, Abstract #9.

Brann, D.W., Putnam, C.D. and Mahesh, V.B. (1992) Progesterone and corticosteroid effects on hypothalamic and pituitary opioid concentrations during LH surge induction. Ninth International Congress of Endocrinology, Abstract #65.

Mahesh, V.B. and Brann, D.W. (1994) Glutamate: A major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion. IX International Congress on Hormonal Steroids, Abstract 41.

Bhat, G.K., Mahesh, V.B., Brann, D.W. (1996) Nitric oxide production and mechanism of action in the hypothalamus: Role of cGMP and modulation by opioids. Tenth International Congress of Endocrinology, Abstract P2-525.

Zamorano, P.L., Mahesh, V.B., De Sevilla, L.M., Brann, D.W. (1996) Glutamate receptor
expression in the hypothalamus during the onset of puberty in the female rat. Tenth International Congress of Endocrinology, Abstract P1-342.

Unda, R., Brann, D.W., Mahesh, V.B. (1996) Progesterone action during the LH surge:
Suppression of GAD mRNA and protein levels in the hypothalamus. Tenth International Congress of Endocrinology, Abstract P2-526.

Lamar, C.A., Mahesh, V.B., Brann, D.W. (1996) Heme molecules regulate GnRH secretion in GT1-7 cells. Tenth International Congress of Endocrinology, Abstract P1-387.

Brann, D.W., Zuo, Z., Zamorano, P., Mahesh, V.B. (1996) Decreased GnRH neurosecretory response to glutamate agonists in middle-aged female rats on pro-estrus afternoon: A possible role in reproductive aging. Tenth International Congress of Endocrinology, Abstract P1-349.

Brann D.W., Shi B. and Mahesh V.B. (1996) Expression of kinin system genes in the uterus: possible role in implantation and parturition. 5th World Congress of Gynecological Endocrinology, Abstract #p50.

Zamorano, P., Mahesh, V.B., De Sevilla L, Chorich L, Bhat G and Brann, D.W. (1997) Regulation of leptin gene expression by 17b-estradiol and leptin. 13th International Symposium of the J. Steroid Biochem& Mol Biol, Monaco.

Mahesh, V.B. and Brann, D.W. (1997) Neuroendocrine mechanisms underlying the control of gonadotropin secretion by steroids. XVIII International Study Group on Steroid Hormones, Rome, Steroids 62:725.

Brann, D.W., Zamorano, P., De Sevilla, L., Mahesh, V.B. (1997) Developmental expression of excitatory amino acid receptors in the hypothalamus of the female rat. XVIII International Study Group on Steroid Hormones, Rome, Steroids 62:735.

Brann, D.W., Zamorano P., De Sevilla L., Mahesh, V.B. (1998) Estradiol regulation of leptin gene expression in adipose tissue of the adult ovariectomized rat. 8th International Congress on Obesity, Paris.

Brann, D.W., Rao, I.M., Mahesh, V.B. (1988) Interaction of Progesterone and Estradiol in the Modulation of Prolactin Release in the Rat. The 70th Annual Meeting of the Endocrine Society, #707.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1989) GABA-A Receptors Mediate
3a-Hydroxy-5a-pregnan-20-one Induced Gonadotropin Secretion. The 71st Annual Meeting of the Endocrine Society, #212.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1989) Antagonism of Estrogen-Induced Prolactin Release by Dihydrotestosterone. The 36th Annual Meeting of the Society for Gynecologic Investigation, #572.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1989) Similarities and Differences in Progesterone and Androgen Modulation of Prolactin, FSH and LH Release; Unexpected Properties of Flutamide. The 22nd Annual Meeting of the Society for the Study of Reproduction, #352.

Putnam, C.D., Brann, D.W., Kolbeck, R.C., Mahesh, V.B. (1990) Mediation of the Effect of
Progesterone and Progesterone Metabolites Upon Uterine Contractility by the Progesterone and GABAA Receptor Systems. The 46th Annual Meeting of the American Fertility Society, Oct., 1990.

Putnam, C.D., Brann, D.W., Mahesh, V.B. (1990) Effect of a Specific Pituitary 5a-Reductase Inhibitor Upon Progesterone-Induced Gonadotropin Release. The 23rd Annual Meeting of the Society for the Study of Reproduction, #235.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Dose-Related Effects of Progesterone and Dihydroprogesterone upon Estrogen-Induced Prolactin Release. The 72nd Annual Meeting of the Endocrine Society, #251.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Corticosteroid Regulation of Gonadotropin Secretion and Induction of Ovulation in the Rat. The 74th Annual Meeting of the Federation of American Societies for Experimental Biology, #4038.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Corticosteroid Regulation of Gonadotropin and Prolactin Secretion in the Rat. 37th Mtg Society for Gynecologic Investigation, #47.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1990) Selective Release of Follicle-Stimulating
Hormone by natural and synthetic corticosteroids. The Symposia on the Regulation and Actions of Follicle-Stimulating Hormone, Oct. 1990. Serono Symposia, USA, Abstract #7.

Brann, D.W., McDonald, J.K., Putnam, C.D., Mahesh, V.B. (1990) Changes in MBH LHRH and NPY Associated With Progesterone and Triamcinolone Acetonide- Induced LH and FSH Release. The 20th Annual Meeting of the Society for Neuroscience, Abstract #3770.

Brann, D.W., Putnam, C.D., Mahesh, V.B. (1991) The ACTH-Adrenal Axis: Possible role and significance in the regulation of gonadotropin secretion. The 24th Annual Meeting of the Society for the Study of Reproduction, #392.

Brann, D.W. and Mahesh, V.B. (1991) A possible role for a1 and a2 adrenergic receptors in the mediation of progesterone and corticosteroid-induced gonadotropin secretion in the female rat. Society for Gynecological Investigation, Abstract #191.

Brann, D.W. and Mahesh, V.B. (1991) Role of endogenous excitatory amino acids in the
preovulatory and steroid-induced surge of gonadotropins in the female rat. The 73rd Meeting of the Endocrine Society, Abstract #342.

Brann, D.W. and Mahesh, V.B. (1991) GABA-Opioid-Adrenergic interactions in the regulation of gonadotropin secretion in the female rat. The 21st Annual Meeting of The Society for Neuroscience, Abstract #284:10.

Hendry, L.B., Brann, D.W., Steinsapir J, and Mahesh V.B. (1992) Predicting structure and
function stereochemical fit of candidate ligands into DNA. Keystone Symposium on Molecular and Cellular Biology, page 50.

Brann, D.W., O'Conner, J.C., Wade, M. and Mahesh, V.B. (1992) Divergent regulation of anterior pituitary LHb, FSHb and alpha subunit mRNA levels by progesterone in intact versus ovariectomized estrogen-primed immature rats. The 25th Annual Meeting of the Society for the Study of Reproduction, Abstract # 432.

Gao, X., Greenbaum L.M., Mahesh, V.B. and Brann, D.W. (1992) Changes in ovarian kininogen and kallikrein concentrations during the ovulatory process in the rat. The 25th Annual Meeting of the Society for the Study of Reproduction, Abstract #455.

Hendry, L.B., Muldoon, T.G., Brann, D.W. and Mahesh V.B. (1992) Hormone structure, function and activity predicted by stereochemical fit of candidate ligands into DNA. The 74th Meeting of the Endocrine Society, Abstract #1494, page 425.

Brann, D.W., O'Conner, J.C., Wade, M. and Mahesh, V.B. (1992) LH and FSH subunit mRNA concentrations during the progesterone induced gonadotropin surge in ovariectomized estrogen-primed immature rats. The 38th Annual Meeting of the Society for Gynecological Investigation, Abstract #617.

O'Conner, J.C., Wade, M., and Brann, D.W., (1993) Pituitary action of NPY in LH and FSH
secretion: Modulation by gonadal steroids. The 75th Meeting of the Endocrine Society, page 343, #1169.

Brann, D.W., Ping L. and Mahesh, V.B. (1993) Possible role of non-NMDA receptor-mediated neurotransmission in steroid-induced and preovulatory gonadotropin surges in the rat. The 75th Meeting of the Endocrine Society, page 345, #1180.

Mahesh, V.B., Chorich L and Brann D.W. (1993) Progesterone-induced galanin mRNA increase in the hypothalamus and pituitary correlate with the gonadotropin surge. The 23rd Annual Meeting of The Society for Neuroscience, Vol 19:619.

Brann D.W., Ping L, Wiedmeier VT and Mahesh VB(1993) Release of glutamate and aspartate from the preoptic area during the progesterone- induced LH surge. The 23rd Annual Meeting of The Society for Neuroscience, Vol 19:619.

Brann, D.W., Zamorano PL, Ping L. and Mahesh, V.B. (1993) Role of excitatory amino acid neurotransmission during puberty in the female rat. The 40th Annual Meeting of the Society for Gynecological Investigation, Abstract #369, page 367.

Kumaresan K., Bhat G., Mahesh V.B. and Brann D.W. (1994) Immunohistochemical localization of AMPA glutamate receptor GluR1-4 subunits in the hypothalamus of the female rat: Effects of steroid hormones. The 76th Meeting of the Endocrine Society, Abstract # 449, page 313.

Brann, D.W., Mahesh, V.B., Greenbaum L.M., and Gao, X. (1994) Kininogens and kallikrein in the plasma, brain and uterus during pregnancy in the rat. The 27th Annual Meeting of the Society for the Study of Reproduction, Abstract 164, page 95.

Brann, D.W., Bhat G., and Mahesh, V.B. (1994) Presence of NMDA R1 receptors in the pituitary: Effect of steroid hormones. XI International Congress On Hormonal Steroids, Abstract D160.

Brann, D.W., Bhat G., and Mahesh, V.B. (1994) Histochemical localization of nitric oxide
synthase in the hypothalamus: Association with GnRH neurons. The 24th Annual Meeting of the Society for Neuroscience, Abstract 272.13.

Mahesh, V.B., L. Ping, and Brann, D.W. (1994) A physiological role for excitatory amino acids in the control of pulsatile LH secretion. The 24th Annual Meeting of theSociety for Neuroscience, Abstract 436.2.

Zamorano P.L., Mahesh V.B., Bhat G.K. and Brann, D.W. (1995) Characterization of ionotropic glutamate receptors in the hypothalamus, anterior pituitary and immortalized GnRH (GT1-7) Neurons. The 77th Meeting of theEndocrine Society, Abstract P3-327, page 550.

Unda R., Brann D.W. and Mahesh, V.B. (1995) Progesterone regulation of glutamic acid
decarboxylase (GAD) gene expression in the hypothalamus during the progesterone-induced LH surge in the rat. The 77th Meeting of the Endocrine Society,Abstract P3-347, page 555.

Ping L., Mahesh V.B., Bhat G.K., Chorich L.P. and Brann D.W. (1995) AMPA receptors and LH secretion: Localization, steroid-dependency and site of action. The 77th Meeting of the Endocrine Society, Abstract P3-354, page 557.

Brann D.W., Bhat G.K., Chorich L.P., Aguan K. and Mahesh V.B. (1995) Nitric oxide synthase (NOS) in the hypothalamus: Localization and steroid regulation. The 28th Annual Meeting of the Society for the Study of Reproduction, Abstract 397, page 156.

Zamorano P.L., Mahesh V.B., Chorich L.P., De Sevilla L.M. and Brann, D.W. (1996) Expression of leptin receptor messenger ribonucleic acid (mRNA) in neuroendocrine and endocrine tissues of the rat. The 26th Annual Meeting of the Society for Neuroscience, Abstract #42.18.

Shi B., Mahesh V.B., Bhat G.K. and Brann D.W. (1997) Bradykinin regulates gonadotropinreleasing hormone secretion. The 79th Meeting of the Endocrine Society, Abstract.

Lamar C., Bhat G.K., Mahesh V.B. and Brann D.W. (1997) Evidence that neuronal nitric oxide synthase increases in the hypothalamus on proestrus afternoon. The 79th Meeting of the Endocrine Society, Abstract # OR16-6.

Zamorano P.L., Mahesh V.B., De Sevilla L.M., Chorich L.P. and Brann D.W. (1997) Expression of excitatory amino acid receptors in the hypothalamus during the estrus cycle of the female rat. The 79th Mtg Endocrine Society, Abstract.

Rapkin A., Morgan M. Brann D.W., Wiedmeier V., Simone D., Mahesh V.B. (1997) Anxiolytic steroid levels in premenstrual syndrome. J Soc Gynecol Invest 4: Abstract 130, page 11A.

Zamorano P., Mahesh V.B., DeSevilla L. and Brann D.W. (1997) Excitatory amino acid receptor mRNA levels in the hypothalamus during the proesterone-induced LH surge in estrogen-primed female rats. 27th Annual Meeting of the Society for Neuroscience Abstract 19.1

Lamar C., Bhat G., Mahesh V.B., Brann D.W. (1997) Stimulation of GnRH release by heme molecules – Further studies on the mechanism of action. 27th Annual Meeting of the Society for Neuroscience Abstract 591.7

Wade M., Bhat G., Zamorano P., Mahesh V.B., Brann, D.W. (1998) Use of mRNA differential display to examine the regulation of GnRH secretion and mRNA synthesis by PMA in GT1-7 neuronal cells. The 80th Meeting of the Endocrine Society, Abstract 278.

Brann D.W., Zamorano P., DeSevilla L., Mahesh V.B. (1998) Estradiol regulation of leptin gene expression in the female rat. XVIII International Study Group on Steroid Hormones, Steroids 62:735.

Lamar, C.A., Bhat G.K., Mahesh V.B., Brann D.W. (1998) Localization of PSD-95 in the
hypothalamus and changes during proestrus in the rat. The 80th Meeting of the Endocrine Society, Abstract 270.

Wade M.F., Mahesh V.B., Bhat G.K., Zamorano P.L., Brann D.W. (1999) Examination of the regulation of GnRH secretion and mRNA synthesis by PMA in GT1-7 cells: utilization of the mRNA differential display technique. Annual Meeting of the Society for the Study of Reproduction, Abstract.

Brann D.W., De Sevilla L.M.., Mahesh V.B., Wade M.F. (1999) Identification of genes which are differentially expressed during adipocyte differentiation. 9th European Congress on Obesity, Abstract.

Dhandapani K.M., Mahesh V.B., Brann D.W. (2000) The novel opioid family member, Orphanin FQ regulates GnRH secretion. 2000 Experimental Biology Meeting, Abstract 436.1.

Wade M, Buchanan C, De Sevilla L, Mahesh V.B., Brann D.W. (2000) Estrogen-Astrocyte-GnRH signaling: A possible role for transforming growth factor-b. 33rd Annual Meeting for the Society for the Study of Reproduction, Abstract 249.

Dhandapani K, Hadman M, Buchanan C, Wade M, Mahesh VB, Brann D.W. (2000) Glial cellderived Transforming Growth Factor-b1 protects neurons against cell death. 30th Annual Mtg of the Society for Neuroscience, Abstract 288.15.

Dhandapani K, Wade M, Buchanan C, Brann D.W. (2000) Transforming growth factor-b released by astrocytes enhances connectivity and survival of neurons: regulation by 17b-estradiol. 40th Annual Meeting of the American Society for Cell Biology, Abstract 141.

Brann DW. (2001) Astrocyte-Neuron Interaction and the Regulation of GnRH Secretion. Annual Meeting of the Endocrine Society, Symposium (S31) Abstract.

Dhandapani KM, Brann D.W. (2002) Global gene chip analysis of 17b-estradiol and tamoxifen regulated genes in the rat cerebral cortex. American Society for Neurochemistry Annual Meeting, Abstract, J. Neurochem 81 Suppl 1: page 88.

Wade M, Brann D.W. (2002) Identification of genes that are differentially expressed in the
female rat hypothalamus during aging utilizing mRNA differential display and DNA gene chip
analysis. 35th Annual Mtg of the Society for the Study of Reproduction, Abstract #502.

Dhanadapani KM, Hadman M, Desevilla L, Brann D.W. (2002) Astrocyte-derived
transforming growth factor-b1 protects GnRH neurons from cell death by stimulating AP-1
mediated transcription. 35th Annual Mtg of the Society for the Study of Reproduction,
Abstract# 4 (SSR Trainee Award Finalist for KMD).

Dhandapani KM, Wade MF, DeSevilla L, Mahesh VB, Brann D.W. (2002) High density gene chip analysis of tamoxifen regulated genes in the cerebral cortex of the adult female rat. Annual Meeting for the Society for Neuroscience, Abstract Z4.

Brann D.W. (2003) Global gene chip analysis and estrogen actions in the brain. 2003 Annual Meeting of the American Society for Neurochemistry.

Wakade C., DeSevilla L., Mahesh V.B., Brann D.W. (2004) The neuroprotective actions of
estrogen and tamoxifen during stroke are correlated with decreased activation of extracellular regulated kinases. 29th International Stroke Conference, . Presentation/Abstract 20.

Brann D.W., Wakade C, De Sevilla L, Mahesh VB, Khan MM. (2004) Kinase profiling
following cerebral ischemia in the rat: regulation by estrogen and tamoxifen. 2004
Experimental Biology Annual Meeting, Abstract #1569.

Brann D.W., Wakade C, De Sevilla L, Mahesh VB, Khan MM. (2004) Estradiol and SERM
regulation of neurogenesis in the subventricular zone following cerebral ischemia in the rat.
2004 Experimental Biology Annual Meeting, Abstract #9090.

Brann D.W., Wade F.M., De Sevilla L., Khan M.M., Mahesh V.B., Dhandapani K.M. (2004)
Identification of potential molecular targets for estrogen/SERM actions in the brain using
genomic and proteomic approaches. 16th International Symposium of the Journal of Steroid
Biochemistry & Molecular Biology, Abstract # 35-L.
 

 

 

Copyright 2005
Medical College of Georgia
All rights reserved.

Institute of Molecular Medicine and Genetics
 Medical College of Georgia
 Please e-mail comments, suggestions or questions to:
Laura Hutcheson, ljhutche@mcg.edu

May 8, 2005