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The Bieberich Lab

Selected Publications


Full articles in peer-reviewed journals

  1. Wang, G., Krishnamurthy, K., Chiang, Y.-W., Dasgupta, S., and Bieberich, E. (2008) Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development. J. Neurochem. Published online.
  2. Bieberich, E. (2008) Ceramide signaling in cancer and stem cells. Future Lipidol. 3, 273-300.
  3. Bieberich, E. (2008) Smart drugs for smarter stem cells: Making SENSe (Sphingolipid-Enhanced Neural Stem cells) of ceramide. Neurosignals 16, 124-139.
  4. Wang, G., Silva, J., Dasgupta, S., and Bieberich, E. (2008) Long-chain ceramide is elevated in Presinilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes. Glia 56, 449-456.
  5. Ritter, E., Perry, A., Yu, J., Wang, T., Lang, L., and Bieberich, E. (2008) Breast Cancer Cell-Derived Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor Are Chemoattractants for Bone Marrow Stromal Stem Cells. Ann. Surg. 247, 310-314.
  6. Krishnamurthy, K., Dasgupta, S., and Bieberich, E. (2007) Development and characterization of a novel anti-ceramide antibody. J. Lipid Res. 48, 968-975.
  7. Krishnamurthy, K., Wang, G., Silva, J., Condie, B.G., and Bieberich, E. (2007) Ceramide regulates atypical PKCzeta /lambda -mediated cell polarity in primitive ectoderm cells: A novel function of sphingolipids in morphogenesis. J Biol Chem. 282, 3379-3390.
  8. Silva, J., Dasgupta, S., Wang, G., Krishnamurthy, K., Ritter, E., and Bieberich, E. (2006) Lipids isolated from bone induce migration of human breast cancer cells. J. Lipid Res. 47, 724-733.
  9. Wang, G., Silva, J., Krishnamurthy, K., and Bieberich, E. (2006) A novel isoform of prostate apoptosis response-4 (PAR-4) that binds to F-actin and prevents apoptosis in neural stem cells. Apoptosis 11, 315-325.
  10. Bieberich, E. (2005) Replacement of insulin by LongR3-IGF-1 allows for the differentiation of ES cells into neuroprogenitors and insulin-secreting cells. Anal. Biochem. 346, 185-187.
  11. Wang, G., Krishnamurthy, K., Tran, E., Condie, B., Bieberich, E. (2005) Direct binding to ceramide activates PKCζ prior to the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells. J. Biol. Chem. 280, 26415-26424.
  12. Bieberich, E., Silva, J., Wang, G., Krishnamurthy, K. and Condie, B.G. (2004) Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogs prevents teratoma formation and enriches for neural precursors in ES-cell derived neural transplants. J. Cell Biol. 167, 723-734.
  13. Bieberich, E. (2004) Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: Review and Hypothesis. Glycoconj. J. 21, 313-325.
  14. Slaughter, G.E., Bieberich E., Wnek, G.E., Wynne, K.J., and Guiseppi-Elie, A. (2004) Improving neuron-to-electrode surface attachment via alkanethiol self-assembly: an alternating current impedance study. Langmuir 20, 7189-7200.
  15. Tencomnao, T., Kapitonov, D., Bieberich, E., and Yu, R.K. (2004) Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: Functional role of GC-box and Cre. Glycoconjugate J. 20, 339-351.
  16. Yu, R.K., Bieberich, E., Xia, T., and Zeng, G. (2004) Regulation of ganglioside biosynthesis in the nervous system. J. Lipid Res. 45, 783-793.
  17. Bieberich, E. and Guiseppi-Elie, A. (2004) Neuronal differentiation and synapse formation of PC12 and embryonic stem cells on interdigitated micro-electrode arrays: Contact structures for neuron-to-electrode signal transmission (NEST). Biosensors and Bioelectronics 19, 923-931.
  18. Bieberich, E., MacKinnon, S., Silva, J., Noggle, S., and Condie, B. (2003) Regulation of cell death in mitotic neural progenitors by asymmetric distribution of prostate apoptosis response-4 (PAR-4) and simultaneous elevation of endogenous ceramide. J. Cell Biol., 162, 469-479.
  19. Silva, J., Beckedorf, A., and Bieberich, E. (2003) Osteoblast-derived oxysterol is a migration-inducing factor in human breast cancer cells. J. Biol. Chem., 278, 25376-25385.
  20. Bieberich, E., MacKinnon, S., Silva, J., Li, D.D., Tencomnao, T., Irwin, L.N., Kapitonov, D., and Yu, R.K. (2002) Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases. Biochemistry 41, 11479-11487.
  21. Bieberich, E. (2002) Recurrent fractal neural networks: a strategy for the exchange of local and global information processing in the brain. Biosystems 66, 145-164.
  22. Bieberich, E., Hu, B., Silva, J., MacKinnon, S., Yu, R.K., Fillmore, H., Broaddus, W., and Ottenbrite, R. (2002) Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells. Cancer Lett., 181, 55-64.
  23. Bieberich, E., MacKinnon, S., Silva, J., and Yu, R.K. (2001) Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides. J. Biol. Chem. 276, 44396-44404.
  24. Yu, R.K. and Bieberich, E. (2001) Regulation of glycosyltransferases in ganglioside biosynthesis by phosphorylation and dephosphorylation. Mol. Cell. Endocrinology, 177, 19-24.
  25. Liour, S.S., Jones, M.Z., Suzuki, M., Bieberich, E., and Yu, R.K. (2001) Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID. Mol. Gen. Metabol. 72, 239-247.
  26. Ren, S., Kambe, N., Du, Z., Li, Y., Kambe, M., Xia, H., Bieberich, E., Pozez, A., Grimes, M., Irani, A.-M., and Schwartz, L.B. (2001) Disialoganglioside GD3 is selectively expressed by developing and mature human mast cells. J. Allergy Clin. Immunol. 107, 322-330.
  27. Bieberich, E., Kawaguchi, T., and Yu, R.K. (2000) N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells. J. Biol. Chem. 275, 177-181.
  28. Bieberich, E., Kapitonov, D., and Yu, R.K. (2000) Protein-Ribosome-mRNA (PRIME) display: Affinity isolation of enzyme-ribosome-mRNA complexes and cDNA cloning in a single tube reaction, Anal. Biochem. 287, 294-298.
  29. Bieberich, E., Tencomnao, T., Kapitonov, D., and Yu, R.K. (2000) Effect of N-glycosylation on turnover and subcellular distribution of sialyltransferase II and N-acetylgalactosaminyl transferase I in neuroblastoma cells. J. Neurochem., 74, 2359-2364.
  30. Bieberich, E. (2000) Probing quantum coherence in a biological system by means of DNA-amplification. Biosystems 57, 109-124.
  31. Bieberich, E., Liour, S.-S., and Yu, R.K. (2000) Mammalian ganglioside sialidases: Preparation and activity assays. Methods Enzymol. 312, 339-358.
  32. Bieberich, E., Freischütz, B., Suzuki, M., and Yu, R.K. (1999) Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells. J. Neurochem. 72, 1040-1049.
  33. Zeng, G., Li, D.D., Gao, L., Birkle, S., Bieberich, E., Tokuda, A., and Yu, R.K. (1999) Alteration of ganglioside composition by stable transfection with antisense vectors. Biochemistry 38, 8762-8769.
  34. Kapitonov, D., Bieberich, E., and Yu, R.K. (1999) Combinatorial PCR approach to homology based cloning; cloning and expression of mouse and human GM3-synthase. Glycoconj. J. 16, 337-350.
  35. Bieberich, E. and Yu, R.K. (1999) Multi-enzyme kinetic analysis (MEKA) of ganglioside biosynthesis, Biochim. Biophys. Acta 1432, 113-124.
  36. Bieberich, E., Freischütz, B., Liour, S.-S., and Yu, R.K. (1998) Regulation of ganglioside metabolism by  phosphorylation and dephosphorylation, J. Neurochem. 71, 972-979.
  37. Bieberich, E., Treml, K., Völker, C., Rolfs, A., Kalz-Füller, B. and Bause, E. (1997) Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. Eur. J. Biochem.246, 681-689, 1997.
  38. Bieberich, E. and Bause, E. (1995) Man9-mannosidase from human kidney is expressed in COS cells as a Golgi  resident type II transmembrane N-glycoprotein. Eur. J. Biochem. 233, 644-649.
  39. Kalz-Füller, B., Bieberich, E. and Bause, E. (1995) Cloning and expression of glucosidase I from human hippo-campus. Eur. J. Biochem. 231, 344-351.
  40. Bause, E., Bieberich, E., Rolfs, A., Völker, C. and Schmidt, B.(1993) Molecular cloning and primary structure of  Man9-mannosidase from human kidney. Eur. J. Biochem. 217, 535-540.
  41. Bieberich, E. and Legler, G. (1989): Intracellular activity of lysosomal glucosylceramidase measured with 4-nonyl- umbelliferyl beta-glucoside. Biol. Chem. Hoppe-Seyler 370, 809-817.
  42. Legler, G. and Bieberich, E. (1988) Active site directed inhibition of a cytosolic beta-glucosidase from calf liver by  bromoconduritol B epoxide and bromoconduritol F. Arch. Biochem. Biophys. 260, 437-442.
  43. Legler, G. and Bieberich, E. (1988) Isolation of a cytosolic beta-glucosidase from calf liver and characterization of its active site with alkyl glucosides and basic glycosyl derivatives. Arch. Biochem.Biophys. 260, 427-436.

Book Chapters

Bieberich, E. and Yu, R.K. (2004) Regulation of glycosyltransferases in ganglioside metabolism by N-glycosylation and enzyme complex formation” in “Lipids: Metabolism and enzymes”, K.S. Das, ed.
 
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June 1st, 2005