| Faculty |
| Staff and Fellows |
| CB&A Graduate Program |
| Graduate Students |
| Graduate Studies Program |
| Anatomical Donations |
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Name: |
Navjotsingh Pabla |
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Mentor: |
Zeng Dong, Ph.D. |
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Year of Entry: |
2005 |
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Education: |
B.S. Biotechnology, S.P. University, India M.S. Biochemistry, M.S. University of Baroda, India |
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Honors / Awards |
2008 Award for Special Contribution Veterans Affairs Medical Center 2007 Excellence in Research Award MCG Graduate Research Day |
Paragraph Describing Interests: |
Previously it has been shown in our lab that p53 is activated during cisplatin induced renal cell death. Currently we are trying to elucidate the upstream events that lead to p53 activation following cisplatin treatment. |
Papers / Presentations |
1. Pabla N, Huang S, Mi QS, Daniel R, Dong Z: ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem 2008, 283(10):6572-6583.
2. Pabla N, Dong Z: Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies (review). Kidney Int 2008,73(9):994-1007.
3. Jiang M, Pabla N, Murphy RF, Yang T, Yin XM, Degenhardt K, White E, Dong Z: Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem 2007, 282(4):2636-2645.
4. Wang J, Pabla N, Wang CY, Wang W, Schoenlein PV, Dong Z: Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53. Am J Physiol Renal Physiol 2006, 291(6):F1300-1307.
5. Bhatt K, Feng L, Pabla N, Liu K, Smith S, Dong Z: Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis. Am J Physiol Renal Physiol 2008, 294(3):F499-507.
6. Jiang M, Wei Q, Pabla N, Dong G, Wang CY, Yang T, Smith SB, Dong Z: Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem Pharmacol 2007, 73(9):1499-1510.
7. Jiang G, Mysona B, Dun Y, Gnana-Prakasam JP, Pabla N, Li W, Dong Z, Ganapathy V, Smith SB: Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. Invest Ophthalmol Vis Sci 2006, 47(12):5576-5582.
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| Poster Presentations |
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