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Research Interests:
Family-based genetic association and linkage disequilibrium methods, Bayesian methods in genetic analysis, genetic epidemiology, population structure, likelihood-based inference.
Dr. Varghese George joined the Medical College of Georgia in 2005 as Professor and Chair of the Department of Biostatistics. Dr. George has a well-established track record of methodological and collaborative research in Biostatistics, Statistical Genetics and Genetic Epidemiology, which started with his doctorate in Statistics from the University of Missouri-Columbia followed by his post-doctoral fellowship in Statistical Genetics at the Louisiana State University Medical Center in New Orleans under Professor Robert Elston. He continued his career as faculty in the Department of Biometry and Genetics at LSUMC, in the Division of Biostatistics at the Medical College of Wisconsin (MCW), and in the Department of Biostatistics at the University of Alabama at Birmingham (UAB). His primary methodological focus at present is on family-based association and linkage disequilibrium methods, population structure and Bayesian methods in genetic analysis. He is the recipient of several NIH-funded grants as Principal Investigator or Co-investigator. Dr. George has extensive experience in the academic world as an administrative leader, a scientist, a mentor, and an educator. During his tenure at UAB and MCW, he was the Director of Graduate Programs in Biostatistics at both places. Also, while at UAB, Dr. George served as the Director of a NIAMS-funded Annual Short course in Statistical Genetics, as the Co-Director of a NHLBI-funded post-doctoral training program in Statistical Genetics and as the Co-Director of a NIDDK-funded Annual Short Course in Statistical Genetics.
Teaching Areas: Graduate teachings in Biostatistics include Probability, Statistical Inference, Statistical Models and Methods, Nonparametric Statistics, Clinical Trials, Likelihood Principle, Applied Regression, Longitudinal Data Analysis, Statistical Genetics, Bayesian Inference, and Advanced Theory of Inference. Other teachings include Biostatistics for Medical Students and MS students in other Health Sciences areas.
Selected Publications:
Xu H, George V: A new transmission test for affected sibships. BMC Genetics, In Press.
Dodani S, Kaur R, Marion L, Sharma G, Reed GL, George V: Can dysfunctional HDL explain high coronary artery disease risk in South Asians? International Journal of Cardiology 129: 125-132
Shekhawat PS, Srinivas SR, Matern D, Bennett MJ, Boriack R, Geroge V, Xu H, Prasad P, Roon P, Ganapathy V (2007): Spontaneous development of intestinal and colonic atrophy and inflammation in a carnitine- deficient jvs (OCTN2-/-) mice. Molecular Genetics and Metabolism 92: 315-24.
Tan D, Fonage M, George V, Xu H (2007): Parent-child pair design for detecting gene-environment interactions in complex diseases. Human Genetics 121:745-57.
Tiwari HK, Beasley TM, George V and Allison DB (2006): Multifactorial Inheritance and Complex Diseases. In “Principles and Practices of Medical Genetics, 5th Ed.”, Eds: Emory and Rimoin. Elsevier, Inc., Philadelphia, PA. pp 299-306.
Tiwari HK, Holt J, George V, Beasley TM, Amos CI and Allison DB (2005): New joint covariance and marginal based tests for association and linkage for quantitative traits for random and non-random sampling. Genetic Epidemiology 28:48-57.
St-Pierre DH, George V, Rabase-Lhoret R and Poehlman ET (2004):
Genetic variation in response to overfeeding and underfeeding in humans. Nutrition 20:145.
Yi N, Xu S, George V and Allison DB (2004):
Mapping Multiple Quantitative Trait Loci for Ordinal Traits. Behavior Genetics 34:3.
Page GP, George V, Go RC, Page PZ and Allison DB (2003):
“Are we there yet?”: Deciding when one has demonstrated specific genetic causation in complex diseases and
quantitative traits. American Journal of Human Genetics 73:711.
Yi N, George V and Allison DB (2003): Stochastic
Search Variable Selection for Identifying Multiple Quantitative Trait Loci.
Genetics 164:1129.
Hajjar IM, George V, Sasse EA and Kochar MS (2002): A randomized double-blind
controlled trial of vitamin C in the management of mild hypertension and lipids.
American Journal of Therapeutics 9:289.
George V
and Laud P (2002): A Bayesian approach to the transmission/disequilibrium test
for binary traits. Genetic Epidemiology 22:41.
Hajjar IM, Grim
CE, George V and Kotchen TA (2001): Impact of diet on blood pressure and
age related changes of blood pressure in the US population: Analysis of the
NHANES-III. Archives of Internal Medicine 161:589.
George V,
Tiwari HK, Zhu X and Elston RC (1999): A test of transmission/disequilibrium for
quantitative traits in pedigree data using multiple regression. American
Journal of Human Genetics 65:236.
George V,
Johnson WD, Shahane A and Nick TG (1997): Testing for treatment effect in the
presence of regression toward the mean. Biometrics 53:49.
Nick TG,
George V, Elston RC and Wilson AF (1995): Statistical validity for testing
associations between genetic markers and quantitative traits in family data.
Genetic Epidemiology 12:145.
George V
and Elston RC (1993): Confidence limits based on the first occurrence of an
event. Statistics in Medicine 12:685.
George V and Johnson WD (1992): Effect of regression to the mean in multivariate distributions.
Communications in Statistics - Theory and Methods 21:333.
George V and Elston RC (1991): Ascertainment - An overview of the classical segregation analysis model
for independent sibships. Biometrical Journal 33:741.
Johnson WD and
George V (1991): Effect of regression to the mean in the presence of with-in
subject variability. Statistics in Medicine 10:1295.
Elston RC and
George V (1989): Age of onset, age at examination and other covariates in
the analysis of family data. Genetic Epidemiology 6:217.
George V and Elston RC (1989): “Biostatistical Methods for the Familial Study of Cancer”.
In Genetic Epidemiology of Cancer, edited by Lynch, HT and
Hirayama, T, CRC Press Inc, Boca Raton, Florida. Chapter 2, pp 23-34.
George V
and Elston RC (1988): A note on estimation using self-contained subsets.
Biometrics 44:249.
George V and Katti SK (1988): A non-Bayesian approach to estimation using tested priors.
Communications in Statistics - Theory and Methods 17:1629.
George V
and Elston RC (1987): Testing the association between polymorphic markers and
quantitative traits in pedigrees. Genetic Epidemiology 4:193.
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Full CV