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Xingming
Shi, PhD
E-mail:
Research Emphasis:
Osteoporosis is a major public health problem affecting 44
million Americans. The estimated direct health care costs for osteoporosis was $17 billion in 2001 and is rising. The research interest of my laboratory is to
study the cellular and molecular mechanisms of glucocorticoid (GC)-induced
osteoporosis and to search for new therapies for the treatment of this
devastating disease.
Selected Publications
Zhang W, Yang N, Shi X-M. Regulation of mesenchymal stem cell osteogenic differentiation by glucocorticoid-induced leucine zipper (GILZ). J Biol Chem. 2008 Feb 22;283(8):4723-9.
Zhang W, Ou G, Hamrick M, Hill W, Borke J, Wenger K, Chutkan N, Yu J, Mi QS, Isales CM, Shi X-M. Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells. J Bone Miner Res. 2008 Jul;23(7):1118-28.
Yang N, Zhang W, Shi X-M. Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression. J Cell Biochem. 2008 Apr 15;103(6):1760-71.
Shi X-M, Shi W, Li Q, Song B, Wan M, Bai S, Cao X. A glucocorticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells.
EMBO Rep. 2003 Apr;4(4):374-80.