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Shirley E. Poduslo,
PhD
E-mail:
Research Emphasis:
Alzheimer’s
disease is one of the most common forms of dementia. We are interested in the genetics of late-onset Alzheimer’s disease as
well as the genetics of other neurodegenerative disorders.
We are establishing a DNA Bank of families having one or more patients
with dementia.
Our studies prior to coming to MCG revealed that there are at least 3
mutated genes that may be the cause of late-onset Alzheimer’s disease.
We are working to identify these mutated genes and determine the
prevalence among Alzheimer’s patients and those with other neurodegenerative
disorders.
We have also identified APOCI A as a risk factor for Alzheimer’s
disease.
APOCI A is in linkage disequilibrium with APOE 4 and the disease.
We believe that late-onset Alzheimer’s disease is a complex disease.
It is likely that multiple genes will be involved, either as risk factors
or as causative agents.
This may account for the disparate responses that patients have or may
have to the various drugs now on the market and those coming on the market.
It is only through research that we will find the cause of these
devastating
diseases and ultimately their prevention.
Visit our website at http://www.mcg.edu/alzres/.
Selected Publications:
N. Lopez-Benitez, A. Rai, K. Kothari, S.E. Poduslo. Parallelization and Analysis of the Linkmap Program in Advances in Computation: Theory and Practice. Volume 15. Nova Science Publishers, Inc, NY. (2004).
D. Cheng, R. Huang, I.S. Lanham, H.M. Cathcart, M. Howard, E.H. Corder, S.E. Poduslo. Functional Interaction between APOE4 and LDL Receptor Isoforms in Alzheimer s Disease. Journal of Medical Genetics, 42:129-131 (2005).
H.M. Cathcart, R. Huang, I.S. Lanham, E.H. Corder, S.E. Poduslo. Cystatin C as a Risk Factor for Alzheimer s Disease. Neurology, 64:755-757 (2005).
G.R. Parker, H.M. Cathcart, R. Huang, I.S. Lanham, E.H. Corder, S.E. Poduslo. APOE Promoter Polymorphisms as Risk Factors for Alzheimer s Disease. Psychiatric Genetics, in press (2005).