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Representative Publications
J. Si, Z. Luo, and Lin Mei: Induction of acetylcholine receptor gene by ARIA requires activation of MAP kinase. J. Biol. Chem. 271:19752-19759, 1996.
J. Si, Q. Wang, and Lin Mei: Essential roles of c-JUN and c-JUN NH2-terminal kinase (JNK) in neuregulin increased expression of acetylcholine receptor epsilon-subunit. J. Neurosci. 19:8498-8508, 1999
S. Won, J. Si, M. Colledge, K.S. Ravichandran, S.C. Froehner, Lin Mei: Neuregulin-increased expression of AChR epsilon-subunit gene requires ErbB3 interaction with Shc. J. Neurochem. 73:2358-2368, 1999
M. Tanowitz, J. Si, G.S. Feng, and Lin Mei: Regulation by neuregulin-mediated AChR synthesis by protein tyrosine phosphatase SHP2. J. Neurosci. 19:9426-9435, 1999
Y.Z. Huang, S.S. Won, D.W. Ali, Q. Wang, M. Tanowitz, Q.S. Du, W.C. Xiong, K.A. Pelkey, M.W. Salter, and Lin Mei. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26:443-455, 2000
Y.X. Tao, Yang Z. Huang, L. Mei and R.A. Johns. Expression of PSD-95/SAP90 is critical for N-Methyl-D-Aspartate receptor-mediated thermal hyper-algesia in the spinal cord. Neuroscience 98:201-206, 2000
X.R. Ren, Q.S. Du, Y.Z. Huang, S.Z. Ao, L. Mei, W.C. Xiong. PSGAP, a novel PH and SH3 domain containing rhoGAP protein, interacts with PYK2 and FAK. J. Cell Biol. 152: 971-984, 2001
Y.Z. Huang, Q. Wang, W.C. Xiong, L. Mei. Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. J. Biol. Chem. 276:19318-19326, 2001
Q.S. Du, X.R. Ren, Q. Wang, L. Mei, and W.C. Xiong. Inhibition of PYK2-induced cytoskeletal reorganization, PYK2 autophosphorylation, and focal adhesion targeting by FAK. J. Cell Sci. 114: 2977-2987, 2001
K. Wong1, X.R. Ren1, Y.Z. Huang, Yi Xie, Guofa Liu, H. Saito, Hao Tang, Leng Wen, S. Brady-Kalnay, L. Mei, J.Y. Wu, W.C. Xiong2, and Y. Rao2. Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway. Cell 107:209-221, 2001 (1, equal contributing first authors; 2, equal corresponding authors)
H.-J. Lee, K.-M. Jung, Y.Z. Huang, L.B. Bennett, J.S. Lee, L. Mei, and T.-W. Kim. Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J. Biol. Chem. 277: 6318-6323, 2002.
Z.G. Luo1, Q. Wang1, J.Z. Zhou, J. Wang, Z. Luo, M. Liu, X. He, A. Wynshaw-Boris, W.C. Xiong, B. Lu, Lin Mei. Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1. Neuron 35:489-505, 2002. (1, equal contributing first authors) (highlighted in Neurobiology Paper Alert, Curr. Opinion Neurobiol. 12:463-470, 2002) (1, equal contributing authors)
Y. Z. Huang, Q. Wang, S. Won, Z.G. Luo; W.C. Xiong, Lin Mei: Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. Int. J. Dev. Neurosci. 726:1-13, 2002
N.S. Hamblet, N. Lijam, P. Ruiz-Lozano, J. Wang, Y. Yang, Z. Luo, L. Mei, K.R. Chien, D.J. Sussman, and A. Wynshaw-Boris: Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129:5827-5838, 2002
S.O., Kim, K. Loesch, X. Wang, J. Jiang, L. Mei, J.M. Cunnick, J. Wu, S.J. Frank. A role for Grb2-associated binder-1 in growth hormone signaling. Endocrinology, 143:4856-4867, 2002
Y.Z. Huang, M. Zang, W.C. Xiong, Z. Luo, Lin Mei. Erbin suppresses the MAP kinase pathway. J. Biol. Chem. 278:1108-1114, 2003 (featured in Science STKE, pe 37, 2003).
L. Ma,* Y.Z. Huang,* G.M. Pitcher, J.G. Valtschanoff, Y.H. Ma, L.Y. Feng, B. Lu, W.C. Xiong, M.W. Salter, R.J. Weinberg, and L. Mei. Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. J. Neurosci. 23:3164-3175, 2003. (highlighted in “This Week in The Journal”, J. Neurosci. 23(8):i, 2003) (*, equal contributing authors)
Q. Wang1, Y. Xie1, Q.-S. Du1, X.-J. Wu, X. Feng, L. Mei, J. McDonald, and W.C. Xiong. Regulation of the formation of osteoclastic actin rings by PYK2 interacting with gelsolin. J. Cell Biol. 160:565-575, 2003 (1, equal contributing authors)
L. Mei and W.C. Xiong: Two birds with one stone: a novel motif for AChR assembly quality control. Trends Neurosci. 26:178-81, 2003
W.C. Xiong and L. Mei. Roles of fak family kinases in nervous system. Front Biosci. 8:S676-682, 2003
C.-H. Kim, Wen C. Xiong, Lin Mei. Regulation of MuSK expression by a novel signaling pathway. J. Biol. Chem. 278:38522-38527, 2003
Z.G. Luo, H.-S. Je, Q. Wang, F. Yang, G. Clem Dobbins, Z.-H. Yang, W.C. Xiong, B. Lu, L. Mei: Implication of geranylgenanyltransferase I in synaptogenesis. Neuron 40:703-717, 2003 (highlighted in “Faculty of 1000”, 2003)
X.-R. Ren, G.-l. Ming, Y. Xie, Y. Hong, D.-m. Sun, Z. Zhao, Z. Feng, Q. Wang, S. Shim, Z. Chen, H.-j. Song, L. Mei, and W.-c. Xiong. Focal Adhesion Kinase in Netrin-1 Signaling. Nature Neurosci. 7:1204-1212, 2004
J. Bao, H. Lin, Y. Ouyang, D. Lei, A. Osman, T.-W. Kim, L. Mei, P. Dai, K.K Ohlemiller, R.T. Ambron. Activity-Dependent Transcription Regulation of PSD-95 by Neuregulin-1 and Eos. Nature Neurosci. 7:1250-1258, 2004
X.L. Yang, Y.Z. Huang, W.C. Xiong, and Lin Mei. Neuregulin-induced Expression of the Acetylcholine Receptor Requires Endocytosis of ErbB Receptors. Mol. Cell. Neurosci. 28:335-346, 2005
W.C. Xiong and Lin Mei: An Unconventional Role of Neurotransmission in Synapse Formation. Neuron 46:521-523, 2005.
C.-H. Kim, W.C. Xiong, L. Mei. Inhibition of MuSK expression by CREB interacting with a CRE-like element and MyoD. Mol. Cell. Biol. 25:5329-5338, 2005
Y. Xie, Y.-Q. Ding, Y. Hong, Z. Feng, S. Navarre, C.-X. Xi, X.-J. Zhu, C.-L. Wang, S. L. Ackerman, D. Kozlowski, Lin Mei, and W.-C. Xiong. Phosphatidylinositol Transfer Protein alpha in Netrin-1-Induced PLC Signaling and Neurite Outgrowth. Nature Cell Biol. 7:1124 – 1132, 2005
P. Dai, W.C. Xiong, and Lin Mei. Erbin inhibits RAF activation by disrupting the SUR-8-RAS-RAF complex. J. Biol. Chem. 281:927-933, 2006
Y. Xie, Y. Hong, X.Y. Ma, X.R. Ren, S. Ackerman, L. Mei, and W.C. Xiong. DCC-dependent PLC signaling in netrin-1-induced neurite elongation. J. Biol. Chem. 281: 2605-2611, 2006
Z. Zhou, D. Immel, C-X. Xi, A. Bierhaus, X. Feng, L. Mei, P. Nawroth, D. M. Stern, and W-C. Xiong. Regulation of Osteoclast Function and Bone Mass by RAGE. J. Exp. Med. 203:1067-1080, 2006
D. Zhu, W.-C. Xiong, and Lin Mei. Lipid Rafts Serve as a Signaling Platform for Nicotinic Acetylcholine Receptor Clustering. J. Neurosci. 26: 4841-4851, 2006
X. P. Dong, X.-M. Li, T.-M. Gao, G.-S. Feng, W.C. Xiong, L. Mei. SHP2 is dispensable for neuromuscular junction formation and maintenance. NeuroSignals, 15:53-62, 2006
X.-J. Zhu, C.-Z. Wang, P.-G. Dai, Y. Xie, N.-N. Song, Y. Liu, Lin Mei, Y.-Q. Ding, and W.-C. Xiong. Myosin X regulates netrin receptors and functions in axonal path-finding. Nature Cell Biology 9:184-192, 2007
I. Calin-Jageman, K. Yu, R.A. Hall, Lin Mei, and A. Lee. Erbin enhances voltage-dependent facilitation of Cav1.3 Ca2+ channels through relief of an autoinhibitory domain in the Cav1.3 alpha1 subunit. J. Neurosci. 27:1374-1385, 2007
Y. Liu, Y. Tao, R.-S. Woo, W.C. Xiong, and Lin Mei. Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons. Biochem. Biophys. Res. Comm. 354:505-510, 2007
Lin Mei and Wen C. Xiong. Signal integration by focal adhesion kinase at point contacts in growth cones. Cell Science Reviews 3:47-53, 2007
B. Zhang,* S.-w. Luo,* X.-P. Dong,* X. Zhang, C. Liu, Z. Luo, W.C. Xiong, L. Mei. β-Catenin regulates AChR clustering in muscle cells through interaction with rapsyn. J. Neurosci. 27:3968-3973, 2007 (high-lighted in This Week in The Journal, Journal of Neuroscience and Nature Review Neuroscience, 8:324, 2007). (*, equal contribution)
B. Li, R.S. Woo, Lin Mei, Roberto Malinow. The neuregulin1 receptor ErbB4 controls glutamatergic synapse maturation and plasticity. Neuron 54:583-597, 2007 (high-lighted in Preview by G. Fischbach, Neuron 54:495-497, 2007; in News and View by L.W. Role and D.A. Talmage Nature 448:263, 2007 and Nature Review Neuroscience, 8:492, 2007).
R.-S. Woo,* X.M. Li,* Y. Tao, E. Carpenter-Hyland, Y.Z. Huang, J. Weber, H. Neiswender, X..-p. Dong, J. Wu, M. Gassmann, C. Lai, W.-C. Xiong, T.-M. Gao, L. Mei. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54:599-610, 2007 (high-lighted in Preview by G. Fischbach, Neuron 54:495-497, 2007; in News and View by L.W. Role and D.A. Talmage Nature 448:263, 2007 and Nature Review Neuroscience, 8:492, 2007). (*, equal contribution)
F. Dai, C. Chang, X. Lin, P. Dai, Lin Mei, and X.-H. Feng. Erbin inhibits TGFβ signaling through a novel Smad-interacting domain. Mol. Cell. Biol. ;27:6183-6194, 2007.
F. Chen,* L. Qian,* Z.-H. Yang, Y. Huang, S.T. Ngo, N.-J. Ruan, J. Wang, C. Schneider, P.G. Noakes, Y.-Q. Ding, Lin Mei, Z.-G. Luo. Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron 55: 247-260, 2007. (*, equal contribution)
C. Brooks, Q. Wei, L. Feng, G. Dong, Y. Tao, L. Mei, Z.-J. Xie, D. C Chan, Z. Dong. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with Mitofusins. Proc. Natl. Acad. Sci., USA 104:11649-11654, 2007
W.C. Xiong and Lin Mei. Neuregulin-1 in schizophrenia. Future Neurology 2:477-480, 2007.
A.L. Gheyara, A. Vallejo-Illarramendi, K. Zang, Lin Mei, R. St-Arnaud, S. Dedhar, and L.F. Reichardt. Deletion of Integrin Linked Kinase (Ilk) from Skeletal Muscles of Mice Resembles Muscular Dystrophy due to 71 Integrin Deficiency. Am. J. Phathol. 171:1966-1977, 2007
Q. Wang,* B. Zhang,* Y.E. Wang, W.C. Xiong, L. Mei. The Ig1/2 Domain of MuSK Binds to Muscle Surface and Is Involved in Acetylcholine Receptor Clustering. Neurosignals. 16:246-253, 2008. (*, equal contribution)
G.M. Pitcher, S. Beggs, R.-S. Woo, Lin Mei and M.W. Salter. ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. NeuroReport 19:139-143, 2008
D. Zhu, Z. Yang, Z. Luo, S. Luo, W.C. Xiong, Lin Mei. MuSK endocytosis in AChR clustering in response to agrin. J. Neurosci. 28:1688-1696, 2008
X.-M. Li,* X.-P. Dong, S.W. Luo, B. Zhang, D.H. Lee, A.K.L. Ting, H. Neiswender, C.H. Kim, E. Carpenter-Hyladn, T.M. Gao, W.C. Xiong, L. Mei. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nature Neurosci. (published online February 17, 2008) (highlighted in News & Views by Fu et al., Nature Neurosci. 2008). (*, equal contribution)
X.R. Ren, Y. Hong, Z. Feng, H.M. Yang, L. Mei, W.C. Xiong. Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. Neurosignals. 16:235-245, 2008.
C.-H. Kim, H.Neiswender, E.J. Baik, W.C. Xiong, and Lin Mei. beta-Catenin interacts with MyoD and regulates its transcription activity. Mol. Cell Biol. 28:2941-2951, 2008
Z. Zhou, J.Y. Han, C.X. Ci, J.X. Xie, X. Feng, C.Y. Wang, Lin Mei, W.C. Xiong. HMGB1 Regulates RANKL-Induced Osteoclastogenesis in a Manner Dependent on RAGE. J. Bone Miner Res. 23:1084-1096, 2008
L. Mei and W.C. Xiong. Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008
J. Arikkath, I. Israely, Y. Tao, Lin Mei, X. Liu, L.F. Reichardt. Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J. Neurosci. 28:7047-7056, 2008
S. Luo, B. Zhang, X.-p. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C.A. Chiu, W.C. Xiong, L. Mei. HSP90β Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance. Neuron 60:97-110, 2008
B. Zhang, S. Luo, Q. Wang, T. Suzuki, W.C. Xiong, Lin Mei. LRP4 serves as a co-receptor of agrin. Neuron 60:285-297, 2008 (highlighted in Nature 455:1153, 2008 and in Nature Review Neurosci., December, 2008)