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Huashun Li,
MD/PhD
Assistant Professor
Developmental Neurobiology Program
Medical College of Georgia
1120 15th Street, Augusta, GA 30912
Office: CA2014; Lab: CA2054A
Office phone: 706-721-7364
Lab phone: 706-721-1757
E-mail:
hli@mcg.edu
Research Emphasis:
The long term goal of my lab is to apply what we learn from developmental & stem
cell biology to regenerative medicine and cancer therapy. Towards this goal, we
are studying fundamental questions such as how stem cell self-renewal and
differentiation are controlled. We are currently focused on studying molecular
control of cortical stem cells and progenitors using comprehensive approaches
including cre-lox gene targeting, genomics, proteomics, in utero
electroporation, imaging, biochemistry, molecular and cell biology.
Current Projects:
- Heterotrimeric G protein signaling in the regulation of cortical neurogenesis and self-renewal of stem cells.
- Chromatin remodeling in asymmetric cell division of cortical neural progenitor cells and stem cells.
- Chromatin remodeling in the control of neurite stability.
- Molecular signaling that controls brain tumor stem cells.
Selected Publications:
Li, H-S., Tierney, C., Wen, L., Wu, J. Y. and Rao, Y. (1997). A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development 124, 603-615.
Li, H-S*., Chen, J-H*., Wu, W*., Fagaly, T., Zhou, L., Yuan, W., Dupuis, S., Jiang, Z-H, Nash, W., Gick, C., Ornitz, D.M., Wu. J.Y. and Rao, Y. (1999) Vertebrate Slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96, 807-818. * These authors contribute equally
Zhu, Y*., Li, H-S*., Zhou, L., Wu, J.Y. and Rao, Y. (1999). Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Neuron 23, 473-85. * These authors contribute equally.
Li, H-S., Wang, D, Shen, Q, Schonemann, M. D., Gorski, J.A., Jones, K. R., Temple, S., Jan, L.Y., and Jan, Y.N. (2003). Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40, 1105-18.
Huang, E.J., Li, H-S., Tang, A.A., Luo, E. J., Wiggins, A. K., Neve, R. L., Zhong, W., Jan, L. Y., and Jan, Y. N. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19:138-51.