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Carlos
M. Isales, M.D.
E-mail:
Research Emphasis:
My main area of interest involves
defining the role of nutrition and the “incretin” hormones in normal bone
turnover. We have identified glucose-dependent insulinotropic peptide (GIP) as a hormone with major anabolic effects on bone and bone derived
cells. We currently use both an in vito model involving primary
rat osteoblasts and an in vivo model involving transgenic mice
overexpressing GIP. By combining these cellular and molecular approaches,
we plan to define the role for GIP signaling in normal bone turnover.
Isales CM, Barrett PQ, Brines M, Bollag WB, Rasmussen H. Parathyroid Hormone Modulates Angiotensin II-Induced Aldosterone Secretion from the Adrenal Glomerulosa Cell, Endocrinology 1991; 129:489-95. Isales CM, LewickiJA, Nee J, Barrett PQ. Atrial Natriuretic Peptide-(7-23) Reduces Cellular cAMP Content and Stimulates a Dihydropyridine-Sensitive Calcium Conductance via a cGMP Independent Mechanism. Am J Physiol, 263: C334-C-342, 1992
McCarthy R, Isales C, Rasmussen H. T-type Calcium Channels in Adrenal Glomerulosa Cells: GTP-Dependent Modulation by Angiotensin II. Proc Natl Acad Sci, 90:3260-3264, 1993
Hayslett J, Macala L, Smallwood JI, Kalghatgi L, Gasalla-Herraiz J, Isales C.,. Adenosine stimulation of Na+ transport is mediated by an A1 receptor and a Ca2+i - dependent mechanism. Kidney International, 47: 1576-1584, 1995. Hayslett JP, Macala LJ, Smallwood J, Kalghatgi L, Gasalla-Herraiz J, Isales C. Vasopressin stimulated electrogenic sodium transport is linked to a Ca2+ -mobilizing signal mechanism, J Biol Chem, 270:16082-16088, 1995Orloff JJ, Ganz MB, Nathanson MH, Moyer MS, Kats Y, Mitnick MA, Behal A, Gasalla-Herraiz J, Isales CM, A Mid-region Parathyroid Hormone-related Peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line, Endocrinology, 1996, 137: 5376-5385
Barman SA, Pauly JR, Isales CM. Canine pulmonary vasoreactivity to serotonin: Role of protein kinase C and tyrosine kinase, Am J Physiol, 1997, 272:H740-H747.
Sangueza O, Wei J, Isales CM. Pancreatic Fibrosis with Islet Cell Pseudoneoplastic Proliferation as a Cause of Hypoglycemia, Ann Int Med. 127:1042-1043,1997.
Barman SA and Isales CM Fenfluramine potentiates canine pulmonary vasoreactivity to endothelin-1, Pulm Pharmacol Ther 1998;11(2-3):183-7. Isales C.M., Min L. and Hoffman W.H.; Acetoacetate and b-Hydroxybutyrate Differentially Regulate Endothelin-1 and Vascular Endothelial Growth Factor in Mouse Brain Microvascular Endothelial Cells, J Diab Comp, 1999; 13:91-7