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Catherine S. Chew, Ph.D.

E-mail:

Research Emphasis:
The major goal of my laboratory is to define the cellular signaling mechanisms that regulate gastric acid secretion by the parietal cell. Acid secretion by this cell type is a major factor in the development of peptic ulcer disease. Our laboratory has developed the first primary cell culture model for such studies. Using this and other cellular models, we have recently identified and cloned three previously unknown signaling proteins that are controlled by independent pathways within the parietal cell and other secretory epithelial cells within the GI tract, lung and kidney. At least two of these proteins are overexpressed in multiple epithelial cancers. We are presently employing a range of molecular, cellular and biochemical techniques to define the cellular localization and to identify other interacting proteins in order to determine the specific functions of these novel proteins.

Selected Publications:
Parente, J.A., Jr., Petropoulos, A., Helman, U., Goldenring, J.R. and C.S. Chew. Purification, cloning and expression of a novel, endogenous calcium-sensitive, 28kDa phosphoprotein. J. Biol. Chem. 271:20096-20101, 1996.

Nakamura, K., C-J. Zhou, J. Parente, and C.S. Chew. Parietal cell MAP kinases: Multiple activation pathways. Am. J. Physiol. 271 (GI Physiol. 34): G640-G649, 1996.

Chew, C.S., C.-J. Zhou, J.A. Parente, Jr. Calcium-independent protein kinase C isoforms may modulate parietal cell HCl secretion. Amer. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G246-G256, 1997.

Calhoun, B.C., L.A. Lapierre, C.S. Chew and J.R. Goldenring. Rab11a redistributes to the apical secretory canaliculus during stimulation of gastric parietal cells. Am. J. Physiol. 275 (Cell Physiol. 44): C163-170, 1998.

Chew, C.S., J.A. Parente, Jr., C-J. Zhou, E. Baranco and X. Chen. Lasp-1 is a regulated phosphoprotein within the cAMP signaling pathway in the gastric parietal cell. Am. J. Physiol. 275 (Cell Physiol. 44): C56-67, 1998.

Chew, C.S., B. Säfsten, and G. Flemström. Calcium signaling in a new cultured duodenal enterocyte model. Am.J. Physiol. 275 (Gastrointest. Liver Physiol. 38): 296-341, 1998.

Parente, J.A., Jr. and C.S. Chew. The combined effect of transfection reagent and plasmid DNA quality on efficient transfection of primary rabbit gastric cells. NIH Qiagen News. Special Edition. p.1-3, 1998

Parente, J.A., Jr., X-Chen, C-Z. Zhou and C.S. Chew. Isolation, cloning and characterization of a new mammalian coronin family member, coroninse, which is regulated within the PKC signaling pathway. J. Biol. Chem. 274: 3017-3032, 1999.

Copyright 2006
Medical College of Georgia
All rights reserved.

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Please email comments, suggestions or questions to:
Laura Hutcheson, ljhutche@mcg.edu 

November 07, 2006