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Richard S. Cameron, Ph.D.
E-mail:
Research Emphasis:
The main research focus of my laboratory is to discern the cellular and molecular mechanisms that participate in the assembly of neuronal cells into functionally effective circuits in the adult mammalian brain. Two major areas comprise present research studies: 1) Studies have been directed toward the identification of radial glial cell plasma membrane proteins that may play a role in the selective cell recognition, cell adhesion, and/or cell motility events during neuronal cell migration. Current studies involve immunochemical and cDNA sequence analysis of two novel membrane proteins that contribute to the membrane junction formed between migrating neurons and radial glial cells. Functional bioassays indicate that both proteins play a prominent role in maintaining neuronal cell motility along radial glial cell substrates; and 2) Analyses have been directed toward characterization of cell signaling mechanisms in astroglial cells that participate in neuronal:glial cell communication. These studies involve the isolation and characterization of endocytic compartments and plasmalemmal
caveolae.
Selected Publications:
Mandell, J.W., E. Townes-Anderson, A.J. Czernik, R. Cameron, P. Greengard, and P. De Camilli. 1990. Synapsins in the vertebrate retina: Absence from ribbon synapses and heterogeneous distribution among conventional synapses. Neuron 5:19-33.
Cameron, R.S., and P. Rakic. 1991. Glial cell lineage in the cerebral cortex: A review and synthesis. Glia 4:1-14.
Matteoli, M., K. Takei, R. Cameron, P. Hurlbut, P.A. Johnson, T.C. Sudhof, R. Jahn, and P. De Camilli. 1991. Association of Rab3A with synaptic vesicles at late stages of the secretory pathway. J. Cell Biology 115:625-634.
Rakic, P., R.S. Cameron, and H. Komuro. 1994. Recognition, adhesion, transmembrane signaling, and cell motility in guided neuronal cell migration. Curr. Opin. Neurobiol. 4:63-69.
Cameron, R.S., L. Klein, A.W. Shyjan, P. Rakic, and R. Levenson. (1994). Neurons and astroglia express distinct subsets of Na+,K+-ATPase a and b subunits. Molecular Brain Res. 21:333-343.
Cameron, R.S., and P. Rakic. (1994). Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells. J. Neurosci., 14:3139-3155.
Anton, E.S., Cameron, R.S., and Rakic, P. (1996). Role of Neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. J. Neurosci., 16: 2283-2293.
Cameron, R.S., Ruffin, J., Cho, N.K., Cameron, P.L., and Rakic, P. (in press). Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron-glial junctional domain polypeptide in neuronal migration.