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Cesar V. Borlongan, Ph.D.
E-mail: cborlongan@mcg.edu
Research Emphasis:My laboratory is geared towards advancing cell transplantation therapy for stroke, Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, epilepsy, and other neurological disorders. Human-derived stem and progenitor cells that have been genetically engineered using viral vectors are currently being examined using in vivo and cell/tissue culture models of these human disorders. The therapeutic effects of immunosuppressants, neurotrophic factors, free radical scavengers, and cognitive enhancers, as well as "enriched environment" are also being studied to improve transplantation functional outcomes. The goal is to elucidate neuronal mechanisms underlying brain injury/degeneration and, in turn, exploit these neuronal pathways via transplantation therapy to induce protection and/or regeneration in diseased or aging brain.
Selected Publications
Borlongan, C.V., Sumaya, I., Moss, D.,
Kumazaki, M., Sakurai, T., Hida, H., Nishino, H. (2003) Melatonin-secreting
pineal gland: a novel tissue source for neural transplantation therapy in
stroke. Cell Transplantation 12:225-234.
Borlongan, C.V. and Emerich, D.F. (2003) Facilitation of drug entry into the
CNS via transient permeation of blood brain barrier: laboratory and preliminary
clinical evidence from bradykinin receptor agonist, Cereport. Brain Research
Bulletin 60:297-306.