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Wendy Bollinger Bollag, Ph.D.
E-mail: wbollag@mcg.edu
Research Interests:
My research concerns signal transduction in two systems: primary cultures of mouse epidermal keratinocytes and bovine adrenal glomerulosa cells. In keratinocytes, I am interested primarily in the role of lipid metabolism, diacylglycerol production and protein kinase C activation in the regulation of growth and differentiation, particularly in response to changes in extracellular calcium concentration and 1,25-dihydroxyvitamin D3.
In the glomerulosa cells, I am investigating the mechanisms underlying time-dependent
potentiation, or priming, a type of cellular memory in which a prior exposure to angiotensin II sensitizes glomerulosa cells to respond to a second stimulation with enhanced aldosterone secretion. Phospholipase D-generated diacylglycerol and protein kinase C are implicated in this phenomenon, and we are currently attempting to determine their roles in the generation of time-dependent
potentiation.
Selected Publications:
Bollag WB, PQ Barrett, CM Isales, M Liscovitch & H Rasmussen. A potential role for phospholipase D in angiotensin II-stimulated aldosterone secretion. Endocrinology. 127: 1436-1443, 1990.
Bollag WB, PQ Barrett, CM Isales & H Rasmussen. Angiotensin II-induced changes in diacylglycerol levels and their potential role in modulating the steroidogenic response. Endocrinology. 128: 231-241, 1991.
Isales CM, PQ Barrett, M Brines, WB Bollag & H Rasmussen. Parathyroid hormone modulates aldosterone secretion from the adrenal glomerulosa cell. Endocrinology. 129: 489-495, 1991.
Barrett PQ, CM Isales, WB Bollag & RT McCarthy. Ca2+ channels and aldosterone secretion: modulation by K+ and atrial natriuretic peptide. Am. J. Physiol. 261: F706-F719, 1991.
Bollag WB, PQ. Barrett, CM. Isales, M Liscovitch and H Rasmussen. Signal transduction mechanisms involved in carbachol-induced aldosterone secretion from bovine adrenal glomerulosa cells. Mol. Cell. Endo. 86: 93-101, 1992.
Bollag WB, J Ducote & CS Harmon. Effects of the selective protein kinase C inhibitor, Ro 31-7549, on the proliferation of cultured mouse epidermal keratinocytes. J. Invest. Dermatol. 100: 240-246, 1993.
Bollag WB, J Ducote & CS Harmon. Regulation of fos-lacZ fusion gene expression in primary mouse epidermal keratinocytes isolated from transgenic mice. Biochem. J. 30:263-270, 1994.
Bollag WB, J Ducote & CS Harmon. Biphasic effects of 1,25-dihydroxyvitamin D3 on primary mouse epidermal keratinocyte proliferation. J. Cell Physiol., 163:248-256,1995.
Barrett PQ, W Bollag & H Rasmussen. Mechanism of action of angiotensin II. In: Hormones and Their Actions, BA Cook, RJB King & HJ van der Molin, eds. Elsevier Biomed. Press, Amsterdam, 1987.
Harmon CS, TD Nevins & W Bollag. Protein kinase C inhibits human hair follicle growth and hair fiber production in organ culture. Br. J. Dermatol. 133: 686-693, 1995.
Colley, WC, YM Altshuller, CK Sue-Ling, NG Copeland,DJ Gilbert, NA Jenkins, KD Branch, SE Tsirka, RJ Bollag, WB Bollag & MA Frohman. Cloning and expression analysis of murine phospholipase D1. Biochem. J., 326:745-753, 1997.
Jung, EM, S Betancourt-Calle, R Mann-Blakeney, T Foushee, CM Isales & WB Bollag. Sustained phospholipase D activation in response to angiotensin II but not carbachol in bovine adrenal glomerulosa cells. Biochem. J., 330:445-451, 1998.
Jung, EM, RD Griner, R Mann-Blakeney & WB Bollag. A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation. J. Invest. Dermatol., 110:318-323, 1998.