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The Layman Lab
Publications Page
Selected publications (in chronological order).
- Layman LC, Edwards JL, Osborne WE, Peak DB, Wall SW,
Gallup DG, Reindollar RH, McDonough PG, KD Lanclos. Human chorionic
gonadotropin-beta gene mutations in women with disorders of hCG
production: recurrent abortion, unexplained infertility, and
gestational trophoblastic neoplasia. Mol Hum Reprod
1997;3:315-320.
- Layman LC, Lee EJ, Peak DB, Namnoum AB, Vu KK, van Lingen
BL, Gray MR, McDonough PG, Reindollar RH, Jameson JL. Delayed
puberty and hypogonadism caused by a mutation in the follicle
stimulating hormone beta-subunit gene. N Engl J Med
1997;337:607-611.
- Layman LC, Peak DB, Reindollar RH, Sohn SH, Gray MR.
Mutation analysis of the gonadotropin releasing hormone receptor
gene structure in idiopathic hypogonadotropic hypogonadism.
Fertil Steril
1997;68:1079-1085.
- Layman LC, Cohen DP, Jin M, Xie J, Li Z, Reindollar RH,
Bolbolan S, Bick DP, Sherins RJ, Duck LW, Musgrove LC, Sellers JC,
Neill JD. Mutations in gonadotropin-releasing hormone receptor cause
hypogonadotropic hypogonadism. Nat Genet
1998;18:14-15.
- Layman LC, Amde S, DP Cohen, Jin M, Xie J. The Finnish
follicle stimulating hormone receptor (FSHR) gene mutation in women
with 46,XX ovarian failure is rare in the United States. Fertil
Steril 1998;69:300-302.
- Layman LC. Mutations in human gonadotropin genes and their
physiologic significance in puberty and reproduction. Fertil
Steril
1999; 71:201-218.
- Cohen DP, Stein EM, Li Z, Matulis CK, Ehrmann DA,
Layman LC. Molecular analysis of the gonadotropin releasing
hormone receptor in polycystic ovarian syndrome. Fertil Steril
1999;72:360-363.
- Layman LC. The molecular basis of human hypogonadotropic
hypogonadism. Mol Genet Metab 1999;68:191-99.
- Taylor H, Block K, Olive D, Bick DP, Sherins RJ,
Layman LC. Absence of EMX2 gene mutations in Kallmann
syndrome. Fertil Steril
1999;72:910-914.
- Achermann JC, Gu W-X, Kotlar TJ, Meeks JJ, Sabacan LP, Seminara
SB, Habiby RL, Hindmarsh PC, Bick DP, Sherins RJ, Crowley Jr. WF,
Layman LC, Jameson JL. Mutational analysis of DAX1 in patients
with hypogonadotropic hypogonadism or pubertal delay. J Clin
Endocrinol Metab 1999;84:4497-4500.
- Layman LC. The genetics of human hypogonadotropic
hypogonadism.
Am J Med Genet 1999;89:240-248.
- Barnes RB, Namnoum A, Rosenfield RL, Layman LC. Effect of
follicle stimulating hormone on ovarian androgen production in a
woman with isolated follicle-stimulating hormone deficiency. N
Engl J Med 2000;343:1197-1198.
- Layman LC, McDonough PG, Cohen DP, Maddox M, Tho SPT,
Reindollar RH. Familial gonadotropin releasing hormone resistance
and hypogonadotropic hypogonadism in a family with multiple affected
individuals. Fertil Steril 2001;75:1148-1155.
- Barnes RB, Namnoum A, Rosenfield RL, Layman LC. The role
of LH and FSH in ovarian androgen secretion and ovarian follicular
development: Clinical studies in a patient with isolated FSH
deficiency and multicystic ovaries. Hum Reprod
2002;17:88-91.
- Layman LC, Porto ALA, Xie J, da Motta LACR, da Motta LDC,
Weiser W, Sluss PM. Partial deficiency of follicle stimulating
hormone (FSH)-dependent phenotype due to an FSH gene mutation,
J Clin Endocrinol Metab 2002;87:3702-3707.
- Layman LC, Xie J, Cohen DP, Smith GD. Clinical phenotype
and infertility treatment in a male with hypogonadotropic
hypogonadism due to Ala129Asp/Arg262Gln gonadotropin releasing
hormone receptor mutations. Fertil Steril 2002;
78:1317-20.
- Clark AD, Layman LC. Analysis of the Cys82Arg mutation in
FSH using a novel FSH expression vector. Fertil Steril
2003;79:379-385.
- Park JK, Ozata M, Chorich LP, Bick DP, Sherins RJ, Ozdemir IE,
Cogan J, Phillips III JA, Layman LC. Study of the PROP1 gene
in a large sample of patients with idiopathic hypogonadotropic
hypogonadism. Clin Endocr 2004;60:147-149.
- Layman LC. Autoantibodies against the follicle
stimulating hormone receptor—association or causation? Clin
Endocrinol
2004;61:414-5.
- Xu N, Podolsky RH, Chudgar P, Chorich LP, Liu C, McDonough PG,
Warrington JA, Layman LC. Screening candidate genes for
mutations in patients with hypogonadotropic hypogonadism using
genome custom resequencing microarrays. Am J Obstet Gynecol
2005;192:1274-1284.
- Bhagavath B, Ozata M, Ozdemir IC, Bolu E, Bick DP, Sherins RJ,
Layman LC. The prevalence of GNRHR mutations in a large
cohort of patients with hypogonadotropic hypogonadism. Fertil
Steril (In press).
- Bhagavath B, Podolsky RH, Ozata M, Bolu E, Bick DP, Kulharya A,
Sherins RJ, Layman LC. Clinical and molecular
characterization of a large sample of patients with hypogonadotropic
hypogonadism. Fertil Steril (In press).
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