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Small Animal Behavior Core Laboratory
Services
Passive
(Inhibitory) Avoidance
Description:
In the Passive (Inhibitory) Avoidance test the subjects learn to avoid a
mild aversive stimulus by remaining in the lighted side of a two-compartment
chamber and not entering the dark (unsafe) side. Technicians record the
median step-through latency (i.e., number of seconds elapsed before subjects
cross into the unsafe side of the chamber), as well as the percentage of
animals from each test group that crosses the threshold within the time
allowed (i.e., 300 sec).
Purpose:
This test is a quick, simple method of assessing the effects of age, genetic
models, or drugs on memory retention.
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