Medical College of Georgia

 Biochemistry and Molecular Biology

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Darren Browning
Assistant Professor; Ph.D., University of Toronto, 1995. My research focuses on the functions of cGMP-dependent protein kinase (PKG), where we use diverse biochemical, molecular, cellular, and whole animal approaches to characterize the role of PKG during inflammation and tumor biology. Our preclinical aims are integrating in vitro work demonstrating ant-tumor functions of this enzyme with mouse cancer models, and parallel studies are investigating PKG function in phagocytosis and gene expression with murine inflammatory models. This work is underpinned by basic questions concerning the structure/function of PKG where we are interested in synthetic regulators of PKG as potential therapeutic agents.
Institutional Faculty List  |  Community of Science  |  Browning Lab

Shuang Huang
Associate Professor; Ph.D., Baylor College of Medicine, Houston, Texas, 1994 Understanding the cellular control of cancer cell invasion with a focus on signaling events essential for both cell migration and protease production; therapeutic targets for anti-cancer treatment.
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Kebin Liu
Assistant Professor; Ph.D. University of Oklahoma, 1997. Resistance of cancer cells to host immune response; Tumor cell-immune cell interaction, acquisition of apoptosis resistance, and tumor progression; Molecular mechanisms underlying abnormal apoptosis signaling pathways in tumor escape variants.
Institutional Faculty List  |  Community of Science  |  Lab web page

Stuart A. Thompson
Associate Professor; Ph.D., The University of North Carolina at Chapel Hill, 1992. Understanding bacterial gene regulation events (including epigenetic regulation) that occur during infection of humans by the gastrointestinal pathogen Campylobacter jejuni; characterizing C. jejuni virulence factors; development of a vaccine against C. jejuni infection.
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Dorothy Tuan
Professor; Ph.D., California Institute of Technology. 

Transcriptional control of globin gene expression; mechanism of globin gene switching during erythroid differentiation; application to gene therapy for sickle cell disease and thalassemia; biological function of ERV-9 human endogenous retrovirus in long-range gene regulation.

Institutional Faculty List 

Muthusamy Thangaraju

Assistant Research Scientist; Ph.D. University of Madras, Tamilnadu, India. Role of plasma membrane transporters in the uptake of histone deacetylase (HDAC) inhibitors into tumor cells; Relevance of these transporters to tumor suppression in mammary gland via HDAC inhibition; Physiologic role of these transporters in apoptosis associated with mammary gland involution; Epigenetic mechanisms responsible for silencing of these transporters in breast cancer; Role of the G-protein-coupled receptors GPR109A and GPR109B in the biology of mammary gland and relevance of these receptors to breast cancer and mammary gland involution; Development of novel therapeutics targeting these transporters and receptors for treatment of breast cancer.